Atropine
Parasympatholytic, Muscarinic antagonist || Purified from Atropa belladonna, Datura stramonium...but found in other plants, mainly solanaceae, anticholinergic (muscarinic)competitive antagonist at central and peripheral cholinergic synapses. || sulfate salt (C17H23NO3)2.H2SO4 MW 676.8 cas 5908-99-6. || 1-hyoscyamine is the name of the active enantiomer
General
Type : Not A\/B H target, Muscarinic antagonist, Drug, Alkaloid, Natural, Azabicyclo, Propionate
Chemical_Nomenclature : endo-(+\/-)-alpha-(Hydroxymethyl)benzene-acetic acid 8-azabicyclo[3.2.1]oct-3-yl ester
Canonical SMILES :
InChI :
InChIKey :
Other name(s) : Ekomine || Harvatrat || Sulfatropinol || hyoscyamine || genatropin || barbidonna || atropen || eyesules || atropine metonitrate || pylostropin || Hyoscyamine (D)- || HSDB 3553 || (+)-Atropine || R-(+)-Hyoscyamine || BRN 0091258 || (+)-Hyoscyamine || Tropan-3alpha-yl || (2R)-3-hydroxy-2-phenylpropanoate || (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl || 1-hyoscyamine
Target
Structures : No structure
Families : BCHE, AlphaBeta_hydrolase
References (28)
| Title : Human Plasma Butyrylcholinesterase Hydrolyzes Atropine: Kinetic and Molecular Modeling Studies - Mukhametgalieva_2024_Molecules_29_2140 |
| Author(s) : Mukhametgalieva A , Mir SA , Shaihutdinova Z , Masson P |
| Ref : Molecules , 29 : , 2024 |
| Abstract : |
| PubMedSearch : Mukhametgalieva_2024_Molecules_29_2140 |
| PubMedID: 38731631 |
| Title : Application of an enantioselective LC-ESI MS\/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine - John_2012_Drug.Test.Anal_4_194 |
| Author(s) : John H , Mikler J , Worek F , Thiermann H |
| Ref : Drug Test Anal , 4 :194 , 2012 |
| Abstract : |
| PubMedSearch : John_2012_Drug.Test.Anal_4_194 |
| PubMedID: 21964777 |
| Title : High-performance liquid-chromatographic tandem-mass spectrometric methods for atropinesterase-mediated enantioselective and chiral determination of R- and S-hyoscyamine in plasma - John_2010_Anal.Chim.Acta_680_32 |
| Author(s) : John H , Eyer F , Zilker T , Thiermann H |
| Ref : Anal Chim Acta , 680 :32 , 2010 |
| Abstract : |
| PubMedSearch : John_2010_Anal.Chim.Acta_680_32 |
| PubMedID: 20969988 |
| Title : The presence of atropinesterase activity in animal plasma - Harrison_2006_Naunyn.Schmiedebergs.Arch.Pharmacol_373_230 |
| Author(s) : Harrison PK , Tattersall JE , Gosden E |
| Ref : Naunyn Schmiedebergs Arch Pharmacol , 373 :230 , 2006 |
| Abstract : |
| PubMedSearch : Harrison_2006_Naunyn.Schmiedebergs.Arch.Pharmacol_373_230 |
| PubMedID: 16736160 |
| Title : The influence of peripheral site ligands on the reaction of symmetric and chiral organophosphates with wildtype and mutant acetylcholinesterases - Radic_1999_Chem.Biol.Interact_119-120_111 |
| Author(s) : Radic Z , Taylor P |
| Ref : Chemico-Biological Interactions , 119-120 :111 , 1999 |
| Abstract : |
| PubMedSearch : Radic_1999_Chem.Biol.Interact_119-120_111 |
| PubMedID: 10421444 |
| Title : Nerve agent poisoning in primates: antilethal, anti-epileptic and neuroprotective effects of GK-11 - Lallement_1998_Arch.Toxicol_72_84 |
| Author(s) : Lallement G , Clarencon D , Masqueliez C , Baubichon D , Galonnier M , Burckhart MF , Peoc'h M , Mestries JC |
| Ref : Archives of Toxicology , 72 :84 , 1998 |
| Abstract : |
| PubMedSearch : Lallement_1998_Arch.Toxicol_72_84 |
| PubMedID: 9456079 |
| Title : Effects of four anticholinesterase-anticholinergic combinations and tracheal extubation on QTc interval of the ECG, heart rate and arterial pressure - Saarnivaara_1998_Acta.Anaesthesiol.Scand_42_460 |
| Author(s) : Saarnivaara L , Simola M |
| Ref : Acta Anaesthesiologica Scandinavica , 42 :460 , 1998 |
| Abstract : |
| PubMedSearch : Saarnivaara_1998_Acta.Anaesthesiol.Scand_42_460 |
| PubMedID: 9563867 |
| Title : Paraoxon: cholinesterase-independent stimulation of transmitter release and selective block of ligand-gated ion channels in cultured hippocampal neurons - Rocha_1996_J.Pharmacol.Exp.Ther_278_1175 |
| Author(s) : Rocha ES , Swanson KL , Aracava Y , Goolsby JE , Maelicke A , Albuquerque EX |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 278 :1175 , 1996 |
| Abstract : |
| PubMedSearch : Rocha_1996_J.Pharmacol.Exp.Ther_278_1175 |
| PubMedID: 8819500 |
| Title : Cholinergic regulation of neurite outgrowth from isolated chick sympathetic neurons in culture - Small_1995_J.Neurosci_15_144 |
| Author(s) : Small DH , Reed G , Whitefield B , Nurcombe V |
| Ref : Journal of Neuroscience , 15 :144 , 1995 |
| Abstract : |
| PubMedSearch : Small_1995_J.Neurosci_15_144 |
| PubMedID: 7823125 |
| Title : Effect of atropine and bispyridinium oximes on respiratory and circulatory function in guinea-pigs poisoned by sarin - Worek_1995_Toxicology_95_123 |
| Author(s) : Worek F , Kirchner T , Szinicz L |
| Ref : Toxicology , 95 :123 , 1995 |
| Abstract : |
| PubMedSearch : Worek_1995_Toxicology_95_123 |
| PubMedID: 7825179 |
| Title : Accumulation of enkephalin, proenkephalin mRNA, and neuropeptide Y in immunologically denervated rat adrenal glands: evidence for divergent peptide regulation - Brimijoin_1995_J.Neurochem_64_1281 |
| Author(s) : Brimijoin S , Dagerlind A , Rao R , McKinzie S , Hammond P |
| Ref : Journal of Neurochemistry , 64 :1281 , 1995 |
| Abstract : |
| PubMedSearch : Brimijoin_1995_J.Neurochem_64_1281 |
| PubMedID: 7861161 |
| Title : Prognostic value of serum cholinesterase in organophosphate poisoning - Nouira_1994_Chest_106_1811 |
| Author(s) : Nouira S , Abroug F , Elatrous S , Boujdaria R , Bouchoucha S |
| Ref : Chest , 106 :1811 , 1994 |
| Abstract : |
| PubMedSearch : Nouira_1994_Chest_106_1811 |
| PubMedID: 7988206 |
| Title : Correlation of time course of blood cholinesterase activity and toxic manifestations of acute methylparathion in antidote treated rats - Venkataraman_1994_Ind.J.Physiol.Pharmacol_38_214 |
| Author(s) : Venkataraman BV , Rani MA , Andrade C , Joseph T |
| Ref : Indian Journal of Physiology & Pharmacology , 38 :214 , 1994 |
| Abstract : |
| PubMedSearch : Venkataraman_1994_Ind.J.Physiol.Pharmacol_38_214 |
| PubMedID: 7814086 |
| Title : Emergency care of insecticide poisonings - Hillman_1994_J.Florida.Med.Assoc_81_750 |
| Author(s) : Hillman JV |
| Ref : Journal of the Florida Medical Association , 81 :750 , 1994 |
| Abstract : |
| PubMedSearch : Hillman_1994_J.Florida.Med.Assoc_81_750 |
| PubMedID: 7815041 |
| Title : Study of respiratory failure in organophosphate and carbamate poisoning - Goswamy_1994_Heart.Lung_23_466 |
| Author(s) : Goswamy R , Chaudhuri A , Mahashur AA |
| Ref : Heart & Lung , 23 :466 , 1994 |
| Abstract : |
| PubMedSearch : Goswamy_1994_Heart.Lung_23_466 |
| PubMedID: 7852061 |
| Title : Primate performance decrements following acute soman exposure: failure of chemical countermeasures - Blick_1994_Pharmacol.Biochem.Behav_49_503 |
| Author(s) : Blick DW , Murphy MR , Brown GC , Hartgraves SL |
| Ref : Pharmacology, Biochemistry & Behavior , 49 :503 , 1994 |
| Abstract : |
| PubMedSearch : Blick_1994_Pharmacol.Biochem.Behav_49_503 |
| PubMedID: 7862701 |
| Title : Age-related changes of cholinergic markers in the rat brain - Yufu_1994_Japan.J.Pharmacol_66_247 |
| Author(s) : Yufu F , Egashira T , Yamanaka Y |
| Ref : Japanese Journal of Pharmacology , 66 :247 , 1994 |
| Abstract : |
| PubMedSearch : Yufu_1994_Japan.J.Pharmacol_66_247 |
| PubMedID: 7869609 |
| Title : Effect of atropine, HLo 7 and HI 6 on respiratory and circulatory function in guinea-pigs poisoned by O-ethyl S-[2-(diisopropylamino) ethyl] methylphosponothioate (VX) - Worek_1994_Pharmacol.Toxicol_75_302 |
| Author(s) : Worek F , Kirchner T , Szinicz L |
| Ref : Pharmacol Toxicol , 75 :302 , 1994 |
| Abstract : |
| PubMedSearch : Worek_1994_Pharmacol.Toxicol_75_302 |
| PubMedID: 7870702 |
| Title : SR 46559A: a novel and potent muscarinic compound with no cholinergic syndrome - Kan_1993_Psychopharmacology_112_219 |
| Author(s) : Kan JP , Steinberg R , Oury-Donat F , Michaud JC , Thurneyssen O , Terranova JP , Gueudet C , Souilhac J , Brodin R , Boigegrain R , et al. |
| Ref : Psychopharmacology , 112 :219 , 1993 |
| Abstract : |
| PubMedSearch : Kan_1993_Psychopharmacology_112_219 |
| PubMedID: 7871023 |
| Title : [A study on acute organophosphorus poisoning--changes in the activity and isoenzyme patterns of serum cholinesterase in human poisoning]. [Japanese] - Yamanaka_1993_Japanese.J.Hyg_48_955 |
| Author(s) : Yamanaka S , Yoshida M , Yamamura Y , Nishimura M , Takaesu Y |
| Ref : Nippon Eiseigaku Zasshi Japanese Journal of Hygiene , 48 :955 , 1993 |
| Abstract : |
| PubMedSearch : Yamanaka_1993_Japanese.J.Hyg_48_955 |
| PubMedID: 8107298 |
| Title : Structure-activity relationship of reversible cholinesterase inhibitors including paraquat - Seto_1988_Arch.Toxicol_62_37 |
| Author(s) : Seto Y , Shinohara T |
| Ref : Archives of Toxicology , 62 :37 , 1988 |
| Abstract : |
| PubMedSearch : Seto_1988_Arch.Toxicol_62_37 |
| PubMedID: 3190453 |
| Title : Hydrodynamic characterization of the size and shape of atropinesterase from Pseudomonas putida - van der Drift_1987_Biochim.Biophys.Acta_912_167 |
| Author(s) : van der Drift AC , Sluiter W , Berends F |
| Ref : Biochimica & Biophysica Acta , 912 :167 , 1987 |
| Abstract : |
| PubMedSearch : van der Drift_1987_Biochim.Biophys.Acta_912_167 |
| PubMedID: 3828356 |
| Title : Comparison of the active sites of atropinesterase and some serine proteases by spin-labeling - van der Drift_1985_Biochemistry_24_5333 |
| Author(s) : van der Drift AC , Moes GW , van der Drift E , Rousseeuw BA |
| Ref : Biochemistry , 24 :5333 , 1985 |
| Abstract : |
| PubMedSearch : van der Drift_1985_Biochemistry_24_5333 |
| PubMedID: 3000432 |
| Title : P NMR and mass spectrometry of atropinesterase and some serine proteases phosphorylated with a transition-state analogue - van der Drift_1985_Biochemistry_24_6894 |
| Author(s) : van der Drift AC , Beck HC , Dekker WH , Hulst AG , Wils ER |
| Ref : Biochemistry , 24 :6894 , 1985 |
| Abstract : |
| PubMedSearch : van der Drift_1985_Biochemistry_24_6894 |
| PubMedID: 3907704 |
| Title : In vivo detection of rabbit atropinesterase - Linn_1979_Lab.Anim.Sci_29_335 |
| Author(s) : Linn JM , Liebenberg SP |
| Ref : Lab Anim Sci , 29 :335 , 1979 |
| Abstract : |
| PubMedSearch : Linn_1979_Lab.Anim.Sci_29_335 |
| PubMedID: 502459 |
| Title : Resolution, purification and characterization of rabbit serum atropinesterase and cocainesterase - |
| Author(s) : Cauthen SE , Ellis RD , Larrison SB , Kidd MR |
| Ref : Biochemical Pharmacology , 25 :181 , 1976 |
| PubMedID: 4075 |
| Title : Genetic polymorphism of plasma carboxylesterases in the rabbit: correlation with pharmacologic and toxicologic effects - |
| Author(s) : Ecobichon DJ , Comeau AM |
| Ref : Toxicol Appl Pharmacol , 27 :28 , 1974 |
| PubMedID: 4852152 |
| Title : Serum esterase genetics in rabbits. I. Phenotypic variation of the prealbumin esterases and classification of atropinesterase and cocainesterase - |
| Author(s) : Van Zutphen LF |
| Ref : Biochemical Genetics , 12 :309 , 1974 |
| PubMedID: 4441364 |