Atropine
Parasympatholytic, Muscarinic antagonist || Purified from Atropa belladonna, Datura stramonium...but found in other plants, mainly solanaceae, anticholinergic (muscarinic)competitive antagonist at central and peripheral cholinergic synapses. || sulfate salt (C17H23NO3)2.H2SO4 MW 676.8 cas 5908-99-6. || 1-hyoscyamine is the name of the active enantiomer
General
Type : Not A\/B H target, Muscarinic antagonist, Drug, Alkaloid, Natural, Azabicyclo, Propionate
Chemical_Nomenclature : endo-(+\/-)-alpha-(Hydroxymethyl)benzene-acetic acid 8-azabicyclo[3.2.1]oct-3-yl ester
Canonical SMILES : CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.OS(=O)(=O)O || CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
InChI : InChI=1S\/C17H23NO3.H2O4S\/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12\;1-5(2,3)4\/h2-6,13-16,19H,7-11H2,1H3\;(H2,1,2,3,4) || InChI=1S\/C17H23NO3\/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12\/h2-6,13-16,19H,7-11H2,1H3\/t13?,14?,15?,16-\/m0\/s1 || InChI=1S\/C17H23NO3\/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12\/h2-6,13-16,19H,7-11H2,1H3\/t13-,14+,15?,16-\/m0\/s1
InChIKey : VJFQPODMEGSXHC-UHFFFAOYSA-N || RKUNBYITZUJHSG-AUSYRVNMSA-N || RKUNBYITZUJHSG-QXULXFAOSA-N
Other name(s) : Ekomine || Harvatrat || Sulfatropinol || hyoscyamine || genatropin || barbidonna || atropen || eyesules || atropine metonitrate || pylostropin || Hyoscyamine (D)- || HSDB 3553 || (+)-Atropine || R-(+)-Hyoscyamine || BRN 0091258 || (+)-Hyoscyamine || Tropan-3alpha-yl || (2R)-3-hydroxy-2-phenylpropanoate || (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl || 1-hyoscyamine
MW : 289.4
Formula : C17H23NO3
CAS_number : 51-55-8
PubChem : 17184, 25817, 637577
UniChem : VJFQPODMEGSXHC-UHFFFAOYSA-N, RKUNBYITZUJHSG-AUSYRVNMSA-N, RKUNBYITZUJHSG-QXULXFAOSA-N
IUPHAR : 320
Wikipedia : Atropine
Target
Families : Atropine ligand of proteins in family
ACHE
References (17)
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| Abstract : |
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| Abstract : |
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| Title : Paraoxon: cholinesterase-independent stimulation of transmitter release and selective block of ligand-gated ion channels in cultured hippocampal neurons - Rocha_1996_J.Pharmacol.Exp.Ther_278_1175 |
| Author(s) : Rocha ES , Swanson KL , Aracava Y , Goolsby JE , Maelicke A , Albuquerque EX |
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| Title : Cholinergic regulation of neurite outgrowth from isolated chick sympathetic neurons in culture - Small_1995_J.Neurosci_15_144 |
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| Ref : Journal of Neuroscience , 15 :144 , 1995 |
| Abstract : |
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| Title : Effect of atropine and bispyridinium oximes on respiratory and circulatory function in guinea-pigs poisoned by sarin - Worek_1995_Toxicology_95_123 |
| Author(s) : Worek F , Kirchner T , Szinicz L |
| Ref : Toxicology , 95 :123 , 1995 |
| Abstract : |
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| Title : Accumulation of enkephalin, proenkephalin mRNA, and neuropeptide Y in immunologically denervated rat adrenal glands: evidence for divergent peptide regulation - Brimijoin_1995_J.Neurochem_64_1281 |
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| Title : Prognostic value of serum cholinesterase in organophosphate poisoning - Nouira_1994_Chest_106_1811 |
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| Title : Correlation of time course of blood cholinesterase activity and toxic manifestations of acute methylparathion in antidote treated rats - Venkataraman_1994_Ind.J.Physiol.Pharmacol_38_214 |
| Author(s) : Venkataraman BV , Rani MA , Andrade C , Joseph T |
| Ref : Indian Journal of Physiology & Pharmacology , 38 :214 , 1994 |
| Abstract : |
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| Title : Emergency care of insecticide poisonings - Hillman_1994_J.Florida.Med.Assoc_81_750 |
| Author(s) : Hillman JV |
| Ref : Journal of the Florida Medical Association , 81 :750 , 1994 |
| Abstract : |
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| Title : Study of respiratory failure in organophosphate and carbamate poisoning - Goswamy_1994_Heart.Lung_23_466 |
| Author(s) : Goswamy R , Chaudhuri A , Mahashur AA |
| Ref : Heart & Lung , 23 :466 , 1994 |
| Abstract : |
| PubMedSearch : Goswamy_1994_Heart.Lung_23_466 |
| PubMedID: 7852061 |
| Title : Primate performance decrements following acute soman exposure: failure of chemical countermeasures - Blick_1994_Pharmacol.Biochem.Behav_49_503 |
| Author(s) : Blick DW , Murphy MR , Brown GC , Hartgraves SL |
| Ref : Pharmacology, Biochemistry & Behavior , 49 :503 , 1994 |
| Abstract : |
| PubMedSearch : Blick_1994_Pharmacol.Biochem.Behav_49_503 |
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| Title : Age-related changes of cholinergic markers in the rat brain - Yufu_1994_Japan.J.Pharmacol_66_247 |
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| Ref : Japanese Journal of Pharmacology , 66 :247 , 1994 |
| Abstract : |
| PubMedSearch : Yufu_1994_Japan.J.Pharmacol_66_247 |
| PubMedID: 7869609 |
| Title : Effect of atropine, HLo 7 and HI 6 on respiratory and circulatory function in guinea-pigs poisoned by O-ethyl S-[2-(diisopropylamino) ethyl] methylphosponothioate (VX) - Worek_1994_Pharmacol.Toxicol_75_302 |
| Author(s) : Worek F , Kirchner T , Szinicz L |
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| Abstract : |
| PubMedSearch : Worek_1994_Pharmacol.Toxicol_75_302 |
| PubMedID: 7870702 |
| Title : SR 46559A: a novel and potent muscarinic compound with no cholinergic syndrome - Kan_1993_Psychopharmacology_112_219 |
| Author(s) : Kan JP , Steinberg R , Oury-Donat F , Michaud JC , Thurneyssen O , Terranova JP , Gueudet C , Souilhac J , Brodin R , Boigegrain R , et al. |
| Ref : Psychopharmacology , 112 :219 , 1993 |
| Abstract : |
| PubMedSearch : Kan_1993_Psychopharmacology_112_219 |
| PubMedID: 7871023 |
| Title : [A study on acute organophosphorus poisoning--changes in the activity and isoenzyme patterns of serum cholinesterase in human poisoning]. [Japanese] - Yamanaka_1993_Japanese.J.Hyg_48_955 |
| Author(s) : Yamanaka S , Yoshida M , Yamamura Y , Nishimura M , Takaesu Y |
| Ref : Nippon Eiseigaku Zasshi Japanese Journal of Hygiene , 48 :955 , 1993 |
| Abstract : |
| PubMedSearch : Yamanaka_1993_Japanese.J.Hyg_48_955 |
| PubMedID: 8107298 |
| Title : Structure-activity relationship of reversible cholinesterase inhibitors including paraquat - Seto_1988_Arch.Toxicol_62_37 |
| Author(s) : Seto Y , Shinohara T |
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| Abstract : |
| PubMedSearch : Seto_1988_Arch.Toxicol_62_37 |
| PubMedID: 3190453 |