Methylparathion
in vivo metabolized to very toxic compound Paraoxon in which oxygen replaces the sulfur atom || Trade names include Bladan M, Cekumethion, Dalf, Dimethyl Parathion, Devithion, E 601, Folidol-M, Fosferno M50, Gearphos, Kilex Parathion, Metacide, Metaphos, Metron, Nitrox 80, Partron M, Penncap-M, Tekwaisa
General
Type : Insecticide, Organophosphate, Sulfur Compound, Organothiophosphate, Derivative of Paraoxon, pNP
Chemical_Nomenclature : dimethoxy-(4-nitrophenoxy)-sulfanylidene-$l^{5}-phosphane
Canonical SMILES : COP(=S)(OC)OC1=CC=C(C=C1)[N+](=O)[O-]
InChI : InChI=1S\/C8H10NO5PS\/c1-12-15(16,13-2)14-8-5-3-7(4-6-8)9(10)11\/h3-6H,1-2H3
InChIKey : RLBIQVVOMOPOHC-UHFFFAOYSA-N
Other name(s) : Phosphorothioic acid O,O-dimethyl O-(4-nitrophenyl) ester || O,O-dimethyl O-p-nitrophenyl phosphorothioate || O,O-dimethyl O-p-nitrophenyl thiophosphate || Methyl-parathion || Methyl parathion || Parathion-methyl || Parathion methyl || metafos (3)
MW : 263.21
Formula : C8H10NO5PS
CAS_number : 298-00-0
PubChem : 4130
UniChem : RLBIQVVOMOPOHC-UHFFFAOYSA-N
Target
Families : Methylparathion ligand of proteins in family
ACHE
References (26)
| Title : Immunotoxicological assessment of methyl parathion in female B6C3F1 mice - Crittenden_1998_J.Toxicol.Environ.Health_54_1 |
| Author(s) : Crittenden PL , Carr R , Pruett SB |
| Ref : J Toxicol Environ Health , 54 :1 , 1998 |
| Abstract : |
| PubMedSearch : Crittenden_1998_J.Toxicol.Environ.Health_54_1 |
| PubMedID: 9588345 |
| Title : Evaluation of organophosphorus pesticide residues in citrus fruits from the Valencian community (Spain) - Torres_1997_J.AOAC.Int_80_1122 |
| Author(s) : Torres CM , Pico Y , Marin R , Manes J |
| Ref : Journal of AOAC International , 80 :1122 , 1997 |
| Abstract : |
| PubMedSearch : Torres_1997_J.AOAC.Int_80_1122 |
| PubMedID: 9325585 |
| Title : Oxidative liver DNA damage in rats treated with pesticide mixtures - Lodovici_1997_Toxicology_117_55 |
| Author(s) : Lodovici M , Casalini C , Briani C , Dolara P |
| Ref : Toxicology , 117 :55 , 1997 |
| Abstract : |
| PubMedSearch : Lodovici_1997_Toxicology_117_55 |
| PubMedID: 9020199 |
| Title : Matrix solid-phase dispersion extraction procedure for multiresidue pesticide analysis in oranges - Torres_1996_J.Chromatogr.A_719_95 |
| Author(s) : Torres CM , Pico Y , Redondo MJ , Manes J |
| Ref : Journal of Chromatography A , 719 :95 , 1996 |
| Abstract : |
| PubMedSearch : Torres_1996_J.Chromatogr.A_719_95 |
| PubMedID: 8589838 |
| Title : Methyl parathion activation by a partially purified rat brain fraction - De Lima_1996_Toxicol.Lett_87_53 |
| Author(s) : De Lima JS , Bastos Neto JdD , Bastos VL , da Cunha JC , Moraes FF , Ferreira MdF , Moreira JdD , Faria MV |
| Ref : Toxicology Letters , 87 :53 , 1996 |
| Abstract : |
| PubMedSearch : De Lima_1996_Toxicol.Lett_87_53 |
| PubMedID: 8701445 |
| Title : Influence of methyl parathion on gametogenic and acetylcholinesterase activity in the testis of whitethroated munia (Lonchura malabarica) - Maitra_1996_Arch.Environ.Contam.Toxicol_30_384 |
| Author(s) : Maitra SK , Sarkar R |
| Ref : Archives of Environmental Contamination & Toxicology , 30 :384 , 1996 |
| Abstract : |
| PubMedSearch : Maitra_1996_Arch.Environ.Contam.Toxicol_30_384 |
| PubMedID: 885496 |
| Title : Selective, solid-matrix dispersion extraction of organophosphate pesticide residues from milk - Di Muccio_1996_J.Chromatogr.A_754_497 |
| Author(s) : Di Muccio A , Pelosi P , Camoni I , Attard Barbini D , Dommarco R , Generali T , Ausili A |
| Ref : Journal of Chromatography A , 754 :497 , 1996 |
| Abstract : |
| PubMedSearch : Di Muccio_1996_J.Chromatogr.A_754_497 |
| PubMedID: 8997741 |
| Title : Time course of inhibition of cholinesterase and aliesterase activities, and nonprotein sulfhydryl levels following exposure to organophosphorus insecticides in mosquitofish (Gambusia affinis) - Boone_1996_Fundam.Appl.Toxicol_29_202 |
| Author(s) : Boone JS , Chambers JE |
| Ref : Fundamental & Applied Toxicology , 29 :202 , 1996 |
| Abstract : |
| PubMedSearch : Boone_1996_Fundam.Appl.Toxicol_29_202 |
| PubMedID: 8742317 |
| Title : Acute toxicity of several organophosphorous insecticides and protection by cholinergic antagonists and 2-PAM on Artemia salina larvae - Sanchez-Fortun_1996_Arch.Environ.Contam.Toxicol_31_391 |
| Author(s) : Sanchez-Fortun S , Sanz F , Barahona MV |
| Ref : Archives of Environmental Contamination & Toxicology , 31 :391 , 1996 |
| Abstract : |
| PubMedSearch : Sanchez-Fortun_1996_Arch.Environ.Contam.Toxicol_31_391 |
| PubMedID: 8854833 |
| Title : Biomonitoring of anticholinesterase pesticides in the soil: usefulness of soil Collembola - Chakravorty_1995_Biomedic.Env.Sci_8_232 |
| Author(s) : Chakravorty PP , Bose S , Joy VC , Bhattacharya S |
| Ref : Biomedical & Environmental Sciences , 8 :232 , 1995 |
| Abstract : |
| PubMedSearch : Chakravorty_1995_Biomedic.Env.Sci_8_232 |
| PubMedID: 8561923 |
| Title : Acute toxicological effects in rats treated with a mixture of commercially formulated products containing methyl parathion and permethrin - Ortiz_1995_Ecotoxicol.Environ.Saf_32_154 |
| Author(s) : Ortiz D , Yanez L , Gomez H , Martinez-Salazar JA , Diaz-Barriga F |
| Ref : Ecotoxicology & Environmental Safety , 32 :154 , 1995 |
| Abstract : |
| PubMedSearch : Ortiz_1995_Ecotoxicol.Environ.Saf_32_154 |
| PubMedID: 8575360 |
| Title : Cytogenetic effects on human lymphocytes of a mixture of fifteen pesticides commonly used in Italy - Dolara_1994_Mutat.Res_325_47 |
| Author(s) : Dolara P , Torricelli F , Antonelli N |
| Ref : Mutat Res , 325 :47 , 1994 |
| Abstract : |
| PubMedSearch : Dolara_1994_Mutat.Res_325_47 |
| PubMedID: 7521012 |
| Title : Correlation of time course of blood cholinesterase activity and toxic manifestations of acute methylparathion in antidote treated rats - Venkataraman_1994_Ind.J.Physiol.Pharmacol_38_214 |
| Author(s) : Venkataraman BV , Rani MA , Andrade C , Joseph T |
| Ref : Indian Journal of Physiology & Pharmacology , 38 :214 , 1994 |
| Abstract : |
| PubMedSearch : Venkataraman_1994_Ind.J.Physiol.Pharmacol_38_214 |
| PubMedID: 7814086 |
| Title : Inhibition patterns of brain acetylcholinesterase and hepatic and plasma aliesterases following exposures to three phosphorothionate insecticides and their oxons in rats - Chambers_1993_Fundam.Appl.Toxicol_21_111 |
| Author(s) : Chambers JE , Carr RL |
| Ref : Fundamental & Applied Toxicology , 21 :111 , 1993 |
| Abstract : |
| PubMedSearch : Chambers_1993_Fundam.Appl.Toxicol_21_111 |
| PubMedID: 7689992 |
| Title : Methyl parathion induced alterations in GABAergic system during critical stage of central nervous system development in albino rat pups - Mahaboob_1993_Ind.J.Exp.Biol_31_369 |
| Author(s) : Mahaboob Basha P , Nayeemunnisa |
| Ref : Indian Journal of Experimental Biology , 31 :369 , 1993 |
| Abstract : |
| PubMedSearch : Mahaboob_1993_Ind.J.Exp.Biol_31_369 |
| PubMedID: 8359836 |
| Title : Intermediate syndrome in organophosphorus poisoning: a prospective study - De Bleecker_1993_Crit.Care.Med_21_1706 |
| Author(s) : De Bleecker JL , Van den Neucker K , Colardyn F |
| Ref : Critical Care Medicine , 21 :1706 , 1993 |
| Abstract : |
| PubMedSearch : De Bleecker_1993_Crit.Care.Med_21_1706 |
| PubMedID: 8222687 |
| Title : Genetic toxicity of a mixture of fifteen pesticides commonly found in the Italian diet - Dolara_1993_Cell.Biol.Toxicol_9_333 |
| Author(s) : Dolara P , Vezzani A , Caderni G , Coppi C , Torricelli F |
| Ref : Cell Biol Toxicol , 9 :333 , 1993 |
| Abstract : |
| PubMedSearch : Dolara_1993_Cell.Biol.Toxicol_9_333 |
| PubMedID: 8039010 |
| Title : Cholinesterase reactivation in organophosphorus poisoned patients depends on the plasma concentrations of the oxime pralidoxime methylsulphate and of the organophosphate - Willems_1993_Arch.Toxicol_67_79 |
| Author(s) : Willems JL , De Bisschop HC , Verstraete AG , Declerck C , Christiaens Y , Vanscheeuwyck P , Buylaert WA , Vogelaers D , Colardyn F |
| Ref : Archives of Toxicology , 67 :79 , 1993 |
| Abstract : |
| PubMedSearch : Willems_1993_Arch.Toxicol_67_79 |
| PubMedID: 8481105 |
| Title : Determination of organophosphorous and carbamate insecticides by flow injection analysis - Kumaran_1992_Anal.Biochem_200_187 |
| Author(s) : Kumaran S , Tran-Minh C |
| Ref : Analytical Biochemistry , 200 :187 , 1992 |
| Abstract : |
| PubMedSearch : Kumaran_1992_Anal.Biochem_200_187 |
| PubMedID: 1595894 |
| Title : Inhibition of acetylcholinesterase and butyrylcholinesterase by the organophosphorus insecticide methylparathion in the central nervous system of the golden hamster (Mesocricetus auratus) - Hahn_1991_Acta.Histochem_91_13 |
| Author(s) : Hahn T , Ruhnke M , Luppa H |
| Ref : Acta Histochemica , 91 :13 , 1991 |
| Abstract : |
| PubMedSearch : Hahn_1991_Acta.Histochem_91_13 |
| PubMedID: 1801511 |
| Title : Expression of alternatively terminated unusual human butyrylcholinesterase messenger RNA transcripts, mapping to chromosome 3q26-ter, in nervous system tumors - Gnatt_1990_Cancer.Res_50_1983 |
| Author(s) : Gnatt A , Prody CA , Zamir R , Lieman-Hurwitz J , Zakut H , Soreq H |
| Ref : Cancer Research , 50 :1983 , 1990 |
| Abstract : |
| PubMedSearch : Gnatt_1990_Cancer.Res_50_1983 |
| PubMedID: 2317787 |
| Title : Amplification of butyrylcholinesterase and acetylcholinesterase genes in normal and tumor tissues: putative relationship to organophosphorous poisoning - Soreq_1990_Pharm.Res_7_1 |
| Author(s) : Soreq H , Zakut H |
| Ref : Pharm Res , 7 :1 , 1990 |
| Abstract : |
| PubMedSearch : Soreq_1990_Pharm.Res_7_1 |
| PubMedID: 2405380 |
| Title : Brain cholinergic, behavioral, and morphological development in rats exposed in utero to methylparathion - Gupta_1985_Toxicol.Appl.Pharmacol_77_405 |
| Author(s) : Gupta RC , Rech RH , Lovell KL , Welsch F , Thornburg JE |
| Ref : Toxicol Appl Pharmacol , 77 :405 , 1985 |
| Abstract : |
| PubMedSearch : Gupta_1985_Toxicol.Appl.Pharmacol_77_405 |
| PubMedID: 3975908 |
| Title : Dislodgable insecticide residues on cotton foliage: fenvalarate, permethrin, sulprofos, chlorpyrifos, methyl parathion, EPN, oxamyl, and profenofos - |
| Author(s) : Buck NA , Estesen BJ , Ware GW |
| Ref : Bulletin of Environmental Contamination & Toxicology , 24 :283 , 1980 |
| PubMedID: 6153915 |
| Title : Evaluation of cytotoxic responses caused by selected organophosphorus esters in chick sympathetic ganglia cultures - Obersteiner_1978_Can.J.Comp.Med_42_80 |
| Author(s) : Obersteiner EJ , Sharma RP |
| Ref : Can J Comp Med , 42 :80 , 1978 |
| Abstract : |
| PubMedSearch : Obersteiner_1978_Can.J.Comp.Med_42_80 |
| PubMedID: 565668 |
| Title : Zur Kenntnis neuer, wenig toxischer lnsektizide auf der Basis von Phosphorsaureestern - Schrader_1961_Angew.Chem_73_331 |
| Author(s) : Schrader G |
| Ref : Angewandte Chemie , 73 :331 , 1961 |
| Abstract : |
| PubMedSearch : Schrader_1961_Angew.Chem_73_331 |
| PubMedID: |