Methylparathion

"in vivo metabolized to very toxic compound Paraoxon in which oxygen replaces the sulfur atom" || "Trade names include Bladan M, Cekumethion, Dalf, Dimethyl Parathion, Devithion, E 601, Folidol-M, Fosferno M50, Gearphos, Kilex Parathion, Metacide, Metaphos, Metron, Nitrox 80, Partron M, Penncap-M, Tekwaisa"

General

Type : Insecticide,Organophosphate,Sulfur Compound,Organothiophosphate,Derivative of Paraoxon,pNP

Chemical_Nomenclature : dimethoxy-(4-nitrophenoxy)-sulfanylidene-$l^{5}-phosphane

Canonical SMILES : COP(=S)(OC)OC1=CC=C(C=C1)[N+](=O)[O-]

InChI : InChI=1S\/C8H10NO5PS\/c1-12-15(16,13-2)14-8-5-3-7(4-6-8)9(10)11\/h3-6H,1-2H3

InChIKey : RLBIQVVOMOPOHC-UHFFFAOYSA-N

Other name(s) : Phosphorothioic acid O,O-dimethyl O-(4-nitrophenyl) ester,O,O-dimethyl O-p-nitrophenyl phosphorothioate,O,O-dimethyl O-p-nitrophenyl thiophosphate,Methyl-parathion,Methyl parathion,Parathion-methyl,Parathion methyl,metafos (3)


MW : 263.21

Formula : C8H10NO5PS

CAS_number : 298-00-0

PubChem : 4130

UniChem : RLBIQVVOMOPOHC-UHFFFAOYSA-N

IUPHAR :

Wikipedia :

Target

Families : Methylparathion ligand of proteins in family: ACHE

Stucture :

Protein :

References (26)

Title : Immunotoxicological assessment of methyl parathion in female B6C3F1 mice - Crittenden_1998_J.Toxicol.Environ.Health_54_1
Author(s) : Crittenden PL , Carr R , Pruett SB
Ref : J Toxicol Environ Health , 54 :1 , 1998
Abstract : Crittenden_1998_J.Toxicol.Environ.Health_54_1
ESTHER : Crittenden_1998_J.Toxicol.Environ.Health_54_1
PubMedSearch : Crittenden_1998_J.Toxicol.Environ.Health_54_1
PubMedID: 9588345

Title : Oxidative liver DNA damage in rats treated with pesticide mixtures - Lodovici_1997_Toxicology_117_55
Author(s) : Lodovici M , Casalini C , Briani C , Dolara P
Ref : Toxicology , 117 :55 , 1997
Abstract : Lodovici_1997_Toxicology_117_55
ESTHER : Lodovici_1997_Toxicology_117_55
PubMedSearch : Lodovici_1997_Toxicology_117_55
PubMedID: 9020199

Title : Evaluation of organophosphorus pesticide residues in citrus fruits from the Valencian community (Spain) - Torres_1997_J.AOAC.Int_80_1122
Author(s) : Torres CM , Pico Y , Marin R , Manes J
Ref : Journal of AOAC International , 80 :1122 , 1997
Abstract : Torres_1997_J.AOAC.Int_80_1122
ESTHER : Torres_1997_J.AOAC.Int_80_1122
PubMedSearch : Torres_1997_J.AOAC.Int_80_1122
PubMedID: 9325585

Title : Selective, solid-matrix dispersion extraction of organophosphate pesticide residues from milk - Di Muccio_1996_J.Chromatogr.A_754_497
Author(s) : Di Muccio A , Pelosi P , Camoni I , Attard Barbini D , Dommarco R , Generali T , Ausili A
Ref : Journal of Chromatography A , 754 :497 , 1996
Abstract : Di Muccio_1996_J.Chromatogr.A_754_497
ESTHER : Di Muccio_1996_J.Chromatogr.A_754_497
PubMedSearch : Di Muccio_1996_J.Chromatogr.A_754_497
PubMedID: 8997741

Title : Time course of inhibition of cholinesterase and aliesterase activities, and nonprotein sulfhydryl levels following exposure to organophosphorus insecticides in mosquitofish (Gambusia affinis) - Boone_1996_Fundam.Appl.Toxicol_29_202
Author(s) : Boone JS , Chambers JE
Ref : Fundamental & Applied Toxicology , 29 :202 , 1996
Abstract : Boone_1996_Fundam.Appl.Toxicol_29_202
ESTHER : Boone_1996_Fundam.Appl.Toxicol_29_202
PubMedSearch : Boone_1996_Fundam.Appl.Toxicol_29_202
PubMedID: 8742317

Title : Methyl parathion activation by a partially purified rat brain fraction - De Lima_1996_Toxicol.Lett_87_53
Author(s) : De Lima JS , Bastos Neto JdD , Bastos VL , da Cunha JC , Moraes FF , Ferreira MdF , Moreira JdD , Faria MV
Ref : Toxicology Letters , 87 :53 , 1996
Abstract : De Lima_1996_Toxicol.Lett_87_53
ESTHER : De Lima_1996_Toxicol.Lett_87_53
PubMedSearch : De Lima_1996_Toxicol.Lett_87_53
PubMedID: 8701445

Title : Acute toxicity of several organophosphorous insecticides and protection by cholinergic antagonists and 2-PAM on Artemia salina larvae - Sanchez-Fortun_1996_Arch.Environ.Contam.Toxicol_31_391
Author(s) : Sanchez-Fortun S , Sanz F , Barahona MV
Ref : Archives of Environmental Contamination & Toxicology , 31 :391 , 1996
Abstract : Sanchez-Fortun_1996_Arch.Environ.Contam.Toxicol_31_391
ESTHER : Sanchez-Fortun_1996_Arch.Environ.Contam.Toxicol_31_391
PubMedSearch : Sanchez-Fortun_1996_Arch.Environ.Contam.Toxicol_31_391
PubMedID: 8854833

Title : Influence of methyl parathion on gametogenic and acetylcholinesterase activity in the testis of whitethroated munia (Lonchura malabarica) - Maitra_1996_Arch.Environ.Contam.Toxicol_30_384
Author(s) : Maitra SK , Sarkar R
Ref : Archives of Environmental Contamination & Toxicology , 30 :384 , 1996
Abstract : Maitra_1996_Arch.Environ.Contam.Toxicol_30_384
ESTHER : Maitra_1996_Arch.Environ.Contam.Toxicol_30_384
PubMedSearch : Maitra_1996_Arch.Environ.Contam.Toxicol_30_384
PubMedID: 885496

Title : Matrix solid-phase dispersion extraction procedure for multiresidue pesticide analysis in oranges - Torres_1996_J.Chromatogr.A_719_95
Author(s) : Torres CM , Pico Y , Redondo MJ , Manes J
Ref : Journal of Chromatography A , 719 :95 , 1996
Abstract : Torres_1996_J.Chromatogr.A_719_95
ESTHER : Torres_1996_J.Chromatogr.A_719_95
PubMedSearch : Torres_1996_J.Chromatogr.A_719_95
PubMedID: 8589838

Title : Acute toxicological effects in rats treated with a mixture of commercially formulated products containing methyl parathion and permethrin - Ortiz_1995_Ecotoxicol.Environ.Saf_32_154
Author(s) : Ortiz D , Yanez L , Gomez H , Martinez-Salazar JA , Diaz-Barriga F
Ref : Ecotoxicology & Environmental Safety , 32 :154 , 1995
Abstract : Ortiz_1995_Ecotoxicol.Environ.Saf_32_154
ESTHER : Ortiz_1995_Ecotoxicol.Environ.Saf_32_154
PubMedSearch : Ortiz_1995_Ecotoxicol.Environ.Saf_32_154
PubMedID: 8575360

Title : Biomonitoring of anticholinesterase pesticides in the soil: usefulness of soil Collembola - Chakravorty_1995_Biomedic.Env.Sci_8_232
Author(s) : Chakravorty PP , Bose S , Joy VC , Bhattacharya S
Ref : Biomedical & Environmental Sciences , 8 :232 , 1995
Abstract : Chakravorty_1995_Biomedic.Env.Sci_8_232
ESTHER : Chakravorty_1995_Biomedic.Env.Sci_8_232
PubMedSearch : Chakravorty_1995_Biomedic.Env.Sci_8_232
PubMedID: 8561923

Title : Correlation of time course of blood cholinesterase activity and toxic manifestations of acute methylparathion in antidote treated rats - Venkataraman_1994_Ind.J.Physiol.Pharmacol_38_214
Author(s) : Venkataraman BV , Rani MA , Andrade C , Joseph T
Ref : Indian Journal of Physiology & Pharmacology , 38 :214 , 1994
Abstract : Venkataraman_1994_Ind.J.Physiol.Pharmacol_38_214
ESTHER : Venkataraman_1994_Ind.J.Physiol.Pharmacol_38_214
PubMedSearch : Venkataraman_1994_Ind.J.Physiol.Pharmacol_38_214
PubMedID: 7814086

Title : Cytogenetic effects on human lymphocytes of a mixture of fifteen pesticides commonly used in Italy - Dolara_1994_Mutat.Res_325_47
Author(s) : Dolara P , Torricelli F , Antonelli N
Ref : Mutat Res , 325 :47 , 1994
Abstract : Dolara_1994_Mutat.Res_325_47
ESTHER : Dolara_1994_Mutat.Res_325_47
PubMedSearch : Dolara_1994_Mutat.Res_325_47
PubMedID: 7521012

Title : Methyl parathion induced alterations in GABAergic system during critical stage of central nervous system development in albino rat pups - Mahaboob_1993_Ind.J.Exp.Biol_31_369
Author(s) : Mahaboob Basha P , Nayeemunnisa
Ref : Indian Journal of Experimental Biology , 31 :369 , 1993
Abstract : Mahaboob_1993_Ind.J.Exp.Biol_31_369
ESTHER : Mahaboob_1993_Ind.J.Exp.Biol_31_369
PubMedSearch : Mahaboob_1993_Ind.J.Exp.Biol_31_369
PubMedID: 8359836

Title : Intermediate syndrome in organophosphorus poisoning: a prospective study - De Bleecker_1993_Crit.Care.Med_21_1706
Author(s) : De Bleecker JL , Van den Neucker K , Colardyn F
Ref : Critical Care Medicine , 21 :1706 , 1993
Abstract : De Bleecker_1993_Crit.Care.Med_21_1706
ESTHER : De Bleecker_1993_Crit.Care.Med_21_1706
PubMedSearch : De Bleecker_1993_Crit.Care.Med_21_1706
PubMedID: 8222687

Title : Inhibition patterns of brain acetylcholinesterase and hepatic and plasma aliesterases following exposures to three phosphorothionate insecticides and their oxons in rats - Chambers_1993_Fundam.Appl.Toxicol_21_111
Author(s) : Chambers JE , Carr RL
Ref : Fundamental & Applied Toxicology , 21 :111 , 1993
Abstract : Chambers_1993_Fundam.Appl.Toxicol_21_111
ESTHER : Chambers_1993_Fundam.Appl.Toxicol_21_111
PubMedSearch : Chambers_1993_Fundam.Appl.Toxicol_21_111
PubMedID: 7689992

Title : Genetic toxicity of a mixture of fifteen pesticides commonly found in the Italian diet - Dolara_1993_Cell.Biol.Toxicol_9_333
Author(s) : Dolara P , Vezzani A , Caderni G , Coppi C , Torricelli F
Ref : Cell Biol Toxicol , 9 :333 , 1993
Abstract : Dolara_1993_Cell.Biol.Toxicol_9_333
ESTHER : Dolara_1993_Cell.Biol.Toxicol_9_333
PubMedSearch : Dolara_1993_Cell.Biol.Toxicol_9_333
PubMedID: 8039010

Title : Cholinesterase reactivation in organophosphorus poisoned patients depends on the plasma concentrations of the oxime pralidoxime methylsulphate and of the organophosphate - Willems_1993_Arch.Toxicol_67_79
Author(s) : Willems JL , De Bisschop HC , Verstraete AG , Declerck C , Christiaens Y , Vanscheeuwyck P , Buylaert WA , Vogelaers D , Colardyn F
Ref : Archives of Toxicology , 67 :79 , 1993
Abstract : Willems_1993_Arch.Toxicol_67_79
ESTHER : Willems_1993_Arch.Toxicol_67_79
PubMedSearch : Willems_1993_Arch.Toxicol_67_79
PubMedID: 8481105

Title : Determination of organophosphorous and carbamate insecticides by flow injection analysis - Kumaran_1992_Anal.Biochem_200_187
Author(s) : Kumaran S , Tran-Minh C
Ref : Analytical Biochemistry , 200 :187 , 1992
Abstract : Kumaran_1992_Anal.Biochem_200_187
ESTHER : Kumaran_1992_Anal.Biochem_200_187
PubMedSearch : Kumaran_1992_Anal.Biochem_200_187
PubMedID: 1595894

Title : Inhibition of acetylcholinesterase and butyrylcholinesterase by the organophosphorus insecticide methylparathion in the central nervous system of the golden hamster (Mesocricetus auratus) - Hahn_1991_Acta.Histochem_91_13
Author(s) : Hahn T , Ruhnke M , Luppa H
Ref : Acta Histochemica , 91 :13 , 1991
Abstract : Hahn_1991_Acta.Histochem_91_13
ESTHER : Hahn_1991_Acta.Histochem_91_13
PubMedSearch : Hahn_1991_Acta.Histochem_91_13
PubMedID: 1801511

Title : Amplification of butyrylcholinesterase and acetylcholinesterase genes in normal and tumor tissues: putative relationship to organophosphorous poisoning - Soreq_1990_Pharm.Res_7_1
Author(s) : Soreq H , Zakut H
Ref : Pharm Res , 7 :1 , 1990
Abstract : Soreq_1990_Pharm.Res_7_1
ESTHER : Soreq_1990_Pharm.Res_7_1
PubMedSearch : Soreq_1990_Pharm.Res_7_1
PubMedID: 2405380

Title : Expression of alternatively terminated unusual human butyrylcholinesterase messenger RNA transcripts, mapping to chromosome 3q26-ter, in nervous system tumors - Gnatt_1990_Cancer.Res_50_1983
Author(s) : Gnatt A , Prody CA , Zamir R , Lieman-Hurwitz J , Zakut H , Soreq H
Ref : Cancer Research , 50 :1983 , 1990
Abstract : Gnatt_1990_Cancer.Res_50_1983
ESTHER : Gnatt_1990_Cancer.Res_50_1983
PubMedSearch : Gnatt_1990_Cancer.Res_50_1983
PubMedID: 2317787

Title : Brain cholinergic, behavioral, and morphological development in rats exposed in utero to methylparathion - Gupta_1985_Toxicol.Appl.Pharmacol_77_405
Author(s) : Gupta RC , Rech RH , Lovell KL , Welsch F , Thornburg JE
Ref : Toxicol Appl Pharmacol , 77 :405 , 1985
Abstract : Gupta_1985_Toxicol.Appl.Pharmacol_77_405
ESTHER : Gupta_1985_Toxicol.Appl.Pharmacol_77_405
PubMedSearch : Gupta_1985_Toxicol.Appl.Pharmacol_77_405
PubMedID: 3975908

Title : Dislodgable insecticide residues on cotton foliage: fenvalarate, permethrin, sulprofos, chlorpyrifos, methyl parathion, EPN, oxamyl, and profenofos -
Author(s) : Buck NA , Estesen BJ , Ware GW
Ref : Bulletin of Environmental Contamination & Toxicology , 24 :283 , 1980
PubMedID: 6153915

Title : Evaluation of cytotoxic responses caused by selected organophosphorus esters in chick sympathetic ganglia cultures - Obersteiner_1978_Can.J.Comp.Med_42_80
Author(s) : Obersteiner EJ , Sharma RP
Ref : Can J Comp Med , 42 :80 , 1978
Abstract : Obersteiner_1978_Can.J.Comp.Med_42_80
ESTHER : Obersteiner_1978_Can.J.Comp.Med_42_80
PubMedSearch : Obersteiner_1978_Can.J.Comp.Med_42_80
PubMedID: 565668

Title : Zur Kenntnis neuer, wenig toxischer lnsektizide auf der Basis von Phosphorsaureestern - Schrader_1961_Angew.Chem_73_331
Author(s) : Schrader G
Ref : Angewandte Chemie , 73 :331 , 1961
Abstract : Schrader_1961_Angew.Chem_73_331
ESTHER : Schrader_1961_Angew.Chem_73_331
PubMedSearch : Schrader_1961_Angew.Chem_73_331
PubMedID: