| Title : Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists - Wang_2000_Bioorg.Med.Chem.Lett_10_2247 |
| Author(s) : Wang Y , Chackalamannil S , Hu Z , Clader JW , Greenlee W , Billard W , Binch H , Crosby G , Ruperto V , Duffy RA , McQuade R , Lachowicz JE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 10 :2247 , 2000 |
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Abstract :
Identification of a number of highly potent M2 receptor antagonists with >100-fold selectivity against the M1 and M3 receptor subtypes is described. In the rat microdialysis assay, this series of compounds showed pronounced enhancement of brain acetylcholine release after oral administration. |
| PubMedSearch : Wang_2000_Bioorg.Med.Chem.Lett_10_2247 |
| PubMedID: 11055330 |
Wang Y, Chackalamannil S, Hu Z, Clader JW, Greenlee W, Billard W, Binch H, Crosby G, Ruperto V, Duffy RA, McQuade R, Lachowicz JE (2000)
Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists
Bioorganic & Medicinal Chemistry Lett
10 :2247
Wang Y, Chackalamannil S, Hu Z, Clader JW, Greenlee W, Billard W, Binch H, Crosby G, Ruperto V, Duffy RA, McQuade R, Lachowicz JE (2000)
Bioorganic & Medicinal Chemistry Lett
10 :2247