| Title : Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors - Xu_2006_Bioorg.Med.Chem.Lett_16_5373 |
| Author(s) : Xu J , Wei L , Mathvink RJ , Edmondson SD , Eiermann GJ , He H , Leone JF , Leiting B , Lyons KA , Marsilio F , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 16 :5373 , 2006 |
|
Abstract :
A novel series of oxadiazole based amides have been shown to be potent DPP-4 inhibitors. The optimized compound 43 exhibited excellent selectivity over a variety of DPP-4 homologs. |
| PubMedSearch : Xu_2006_Bioorg.Med.Chem.Lett_16_5373 |
| PubMedID: 16919457 |
| Gene_locus related to this paper: human-DPP4 |
| Inhibitor | 3TP |
| Gene_locus | human-DPP4 |
| Structure | 2HHA |
Xu J, Wei L, Mathvink RJ, Edmondson SD, Eiermann GJ, He H, Leone JF, Leiting B, Lyons KA, Marsilio F, Patel RA, Patel SB, Petrov A, Scapin G, Wu JK, Thornberry NA, Weber AE (2006)
Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors
Bioorganic & Medicinal Chemistry Lett
16 :5373
Xu J, Wei L, Mathvink RJ, Edmondson SD, Eiermann GJ, He H, Leone JF, Leiting B, Lyons KA, Marsilio F, Patel RA, Patel SB, Petrov A, Scapin G, Wu JK, Thornberry NA, Weber AE (2006)
Bioorganic & Medicinal Chemistry Lett
16 :5373