| Title : Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations - Yamakawa_2007_Biochem.Biophys.Res.Commun_355_41 |
| Author(s) : Yamakawa H , Oyama S , Mitsuhashi H , Sasagawa N , Uchino S , Kohsaka S , Ishiura S |
| Ref : Biochemical & Biophysical Research Communications , 355 :41 , 2007 |
|
Abstract :
Recently, neuroligins (NLs)3 and 4X have received much attention as autism-related genes. Here, we identified syntrophin-gamma2 (SNTG2) as a de novo binding partner of NL3. SNTG2 also bound to NL4X and NL4Y. Interestingly, the binding was influenced by autism-related mutations, implying that the impaired interaction between NLs and SNTG2 contributes to the etiology of autism. |
| PubMedSearch : Yamakawa_2007_Biochem.Biophys.Res.Commun_355_41 |
| PubMedID: 17292328 |
| Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
Yamakawa H, Oyama S, Mitsuhashi H, Sasagawa N, Uchino S, Kohsaka S, Ishiura S (2007)
Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations
Biochemical & Biophysical Research Communications
355 :41
Yamakawa H, Oyama S, Mitsuhashi H, Sasagawa N, Uchino S, Kohsaka S, Ishiura S (2007)
Biochemical & Biophysical Research Communications
355 :41