Neuroligin

Relationship

Family: Neuroligin

Block: C

Parent Family: Non-catalytic_C

Comment

Neuroligins constitute a family of proteins thought to mediate cell-to-cell interactions between neurons. Neuroligins function as ligands for the neurexin family and MADD-4. This interaction is necessary for GABA receptors clustering. Mammals have four Nlgn proteins, with the Nlgn3 and Nlgn4 gene in humans localised to the X-chromosome. In humans, the Nlgn4 gene is complemented on the Y-chromosome by a similar Nlgn4Y gene.(from OMIM) In 2 brothers with autism, one with typical autism and the other with Asperger syndrome, Jamain et al. (2003) identified a frameshift mutation (1186T) in the human-NLGN4X gene, resulting in a stop codon at position 396 and premature truncation of the protein before the transmembrane domain. The mutation was present in the mother and absent in an unaffected brother and 350 controls. See other contradictory results Gauthier et al. Vincent et al., but other mutations found Laumonnier et al. Yan et al. Incomplete penetrance suspected for some mutations. In 2 brothers with autism, one with typical autism and the other with Asperger syndrome, Jamain et al. (2003) identified a mutation R451C in the human-NLGN3 gene. arg451 in NLGN3, arg386 in BCHE, and arg395 in ACHE are conserved in mammalian species. In cellular transfection studies, De Jaco et al. (2006) inserted mutations homologous to the NLGN3 R451C mutation in BCHE and ACHE cDNAs and found that these mutations resulted in endoplasmic reticulum retention of the 2 proteins, similar to that observed with the NLGN3 R451C mutant protein. Tabuchi et al. (2007) introduced the R451C substitution in neuroligin-3 into mice. R451C mutant mice showed impaired social interactions but enhanced spatial learning abilities. Unexpectedly these behavioral changes were accompanied by an increase in inhibitory synaptic transmission with no apparent effect on excitatory synapses. Deletion of neuroligin-3, in contrast, did not cause such changes, indicating that the R451C substitution represents a gain-of-function mutation. Tabuchi et al. (2007) concluded that increased inhibitory synaptic transmission may contribute to human autism spectrum disorders and that the R451C knockin mice may be a useful model for studying autism-related behaviors. Recently Venkatesh et al. showed that neuronal activity promotes glioma growth through Neuroligin-3 secretion. Recently Neuroligin 2 mutations were associated with anxiety, autism, intellectual disability, hyperphagia, and obesity.Many mutations on X-linked cell NLGN4X result in ASD or intellectual disability. NLGN4Y cannot compensate for the functional deficits due to NLGN4X mutations (obsolete entries: Interpro IPR030022 Neuroligin-1, IPR030023 Neuroligin-2, IPR030024 Neuroligin-3 IPR030025 Neuroligin-4)

Database

Interpro : IPR000460 Neuroligin , IPR002018 Carboxylesterase, type B

PIRSF : PIRSF005676 COesterase

Pdoc : No Pdoc

Pfam : PF00135 COesterase

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (21)

Genes Proteins in Neuroligin family (517)

Fragments of genes in Neuroligin family (732)

Structures in Neuroligin family (21)

No substrate

No Inhibitor

References (73)

Title : Structural neuroplasticity after sleep loss modifies behavior and requires neurexin and neuroligin - Cowen_2024_iScience_27_109477
Author(s) : Cowen MH , Raizen DM , Hart MP
Ref : iScience , 27 :109477 , 2024
PubMedID: 38551003

Title : Neuroligin-2 shapes individual slow waves during slow-wave sleep and the response to sleep deprivation in mice - Leduc_2024_Mol.Autism_15_13
Author(s) : Leduc T , El Alami H , Bougadir K , Belanger-Nelson E , Mongrain V
Ref : Mol Autism , 15 :13 , 2024
PubMedID: 38570872
Gene_locus related to this paper: human-NLGN2 , mouse-2neur

Title : Mice with an autism-associated R451C mutation in neuroligin-3 show intact attention orienting but atypical responses to methylphenidate and atomoxetine in the mouse-Posner task - Li_2024_Psychopharmacology.(Berl)__
Author(s) : Li S , May C , Pang TY , Churilov L , Hannan AJ , Johnson KA , Burrows EL
Ref : Psychopharmacology (Berl) , : , 2024
PubMedID: 38170320
Gene_locus related to this paper: human-NLGN3 , mouse-3neur

Title : Targeting Wnt\/beta-catenin-mediated upregulation of oncogenic NLGN3 suppresses cancer stem cells in glioblastoma - Yun_2023_Cell.Death.Dis_14_423
Author(s) : Yun EJ , Kim D , Kim S , Hsieh JT , Baek ST
Ref : Cell Death Dis , 14 :423 , 2023
PubMedID: 37443071

Title : Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory versus Inhibitory Synapses - Altas_2023_Biol.Psychiatry__
Author(s) : Altas B , Tuffy LP , Patrizi A , Dimova K , Soykan T , Brandenburg C , Romanowski AJ , Whitten JR , Robertson CD , Khim SN , Crutcher GW , Ambrozkiewicz MC , Yagensky O , Krueger-Burg D , Hammer M , Hsiao HH , Laskowski PR , Dyck L , Puche AC , Sassoe-Pognetto M , Chua JJE , Urlaub H , Jahn O , Brose N , Poulopoulos A
Ref : Biological Psychiatryry , : , 2023
PubMedID: 38154503
Gene_locus related to this paper: human-NLGN3 , mouse-3neur

Title : NLGN4X TCR transgenic T cells to treat gliomas - Kramer_2023_Neuro.Oncol__
Author(s) : Kramer C , Kilian M , Chih YC , Kourtesakis A , Hoffmann DC , Boschert T , Koopmann P , Sanghvi K , De Roia A , Jung S , Jahne K , Day B , Shultz LD , Ratliff M , Harbottle R , Green EW , Will R , Wick W , Platten M , Bunse L
Ref : Neuro Oncol , : , 2023
PubMedID: 37715782
Gene_locus related to this paper: human-NLGN4X , mouse-4neur

Title : Expression alteration of Neuroligin family gene in attention deficit and hyperactivity disorder and autism spectrum disorder - Bay_2023_Res.Dev.Disabil_139_104558
Author(s) : Bay H , Haghighatfard A , Karimipour M , Seyedena SY , Hashemi M
Ref : Res Dev Disabil , 139 :104558 , 2023
PubMedID: 37285744

Title : Multiple N-linked glycosylation sites critically modulate the synaptic abundance of Neuroligin isoforms - Benner_2023_J.Biol.Chem__105361
Author(s) : Benner O , Cast TP , Minamide LS , Lenninger Z , Bamburg JR , Chanda S
Ref : Journal of Biological Chemistry , :105361 , 2023
PubMedID: 37865312

Title : Engineered adhesion molecules drive synapse organization - Hale_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2215905120
Author(s) : Hale WD , Sudhof TC , Huganir RL
Ref : Proc Natl Acad Sci U S A , 120 :e2215905120 , 2023
PubMedID: 36638214

Title : Of Humans and Gerbils- Independent Diversification of Neuroligin-4 Into X- and Y-Specific Genes in Primates and Rodents - Maxeiner_2022_Front.Mol.Neurosci_15_838262
Author(s) : Maxeiner S , Benseler F , Brose N , Krasteva-Christ G
Ref : Front Mol Neurosci , 15 :838262 , 2022
PubMedID: 35431802

Title : Cochlear ribbon synapse maturation requires Nlgn1 and Nlgn3 - Ramirez_2022_iScience_25_104803
Author(s) : Ramirez MA , Ninoyu Y , Miller C , Andrade LR , Edassery S , Bomba-Warczak E , Ortega B , Manor U , Rutherford MA , Friedman RA , Savas JN
Ref : iScience , 25 :104803 , 2022
PubMedID: 35992071

Title : A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y - Nguyen_2020_Neuron_106_759
Author(s) : Nguyen TA , Wu K , Pandey S , Lehr AW , Li Y , Bemben MA , Badger JD, 2nd , Lauzon JL , Wang T , Zaghloul KA , Thurm A , Jain M , Lu W , Roche KW
Ref : Neuron , 106 :759 , 2020
PubMedID: 32243781
Gene_locus related to this paper: human-NLGN4X

Title : The neuroligins and the synaptic pathway in Autism Spectrum Disorder - Trobiani_2020_Neurosci.Biobehav.Rev_119_37
Author(s) : Trobiani L , Meringolo M , Diamanti T , Bourne Y , Marchot P , Martella G , Dini L , Pisani A , De Jaco A , Bonsi P
Ref : Neurosci Biobehav Rev , 119 :37 , 2020
PubMedID: 32991906

Title : Neuroligin 2 nonsense variant associated with anxiety, autism, intellectual disability, hyperphagia, and obesity - Parente_2017_Am.J.Med.Genet.A_173_213
Author(s) : Parente DJ , Garriga C , Baskin B , Douglas G , Cho MT , Araujo GC , Shinawi M
Ref : American Journal of Medicine Genet A , 173 :213 , 2017
PubMedID: 27865048
Gene_locus related to this paper: human-NLGN2

Title : Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion - Venkatesh_2015_Cell_161_803
Author(s) : Venkatesh HS , Johung TB , Caretti V , Noll A , Tang Y , Nagaraja S , Gibson EM , Mount CW , Polepalli J , Mitra SS , Woo PJ , Malenka RC , Vogel H , Bredel M , Mallick P , Monje M
Ref : Cell , 161 :803 , 2015
PubMedID: 25913192
Gene_locus related to this paper: human-NLGN3

Title : C. elegans Punctin Clusters GABA Receptors via Neuroligin Binding and UNC-40\/DCC Recruitment - Tu_2015_Neuron_86_1407
Author(s) : Tu H , Pinan-Lucarre B , Ji T , Jospin M , Bessereau JL
Ref : Neuron , 86 :1407 , 2015
PubMedID: 26028575
Gene_locus related to this paper: caeel-NLGN1

Title : MADD-4\/Punctin and Neurexin Organize C. elegans GABAergic Postsynapses through Neuroligin - Maro_2015_Neuron_86_1420
Author(s) : Maro GS , Gao S , Olechwier AM , Hung WL , Liu M , Ozkan E , Zhen M , Shen K
Ref : Neuron , 86 :1420 , 2015
PubMedID: 26028574
Gene_locus related to this paper: caeel-NLGN1

Title : Tracking the origin and divergence of cholinesterases and neuroligins: the evolution of synaptic proteins - Lenfant_2014_J.Mol.Neurosci_53_362
Author(s) : Lenfant N , Hotelier T , Bourne Y , Marchot P , Chatonnet A
Ref : Journal of Molecular Neuroscience , 53 :362 , 2014
PubMedID: 24390353

Title : Identification and functional characterization of rare mutations of the neuroligin-2 gene (NLGN2) associated with schizophrenia - Sun_2011_Hum.Mol.Genet_20_3042
Author(s) : Sun C , Cheng MC , Qin R , Liao DL , Chen TT , Koong FJ , Chen G , Chen CH
Ref : Hum Mol Genet , 20 :3042 , 2011
PubMedID: 21551456
Gene_locus related to this paper: human-NLGN2

Title : Beyond the random coil: stochastic conformational switching in intrinsically disordered proteins - Choi_2011_Structure_19_566
Author(s) : Choi UB , McCann JJ , Weninger KR , Bowen ME
Ref : Structure , 19 :566 , 2011
PubMedID: 21481779

Title : Neuroscience. Autism's cause may reside in abnormalities at the synapse -
Author(s) : Garber K
Ref : Science , 317 :190 , 2007
PubMedID: 17626859
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : Synaptic arrangement of the neuroligin\/beta-neurexin complex revealed by X-ray and neutron scattering - Comoletti_2007_Structure_15_693
Author(s) : Comoletti D , Grishaev A , Whitten AE , Tsigelny I , Taylor P , Trewhella J
Ref : Structure , 15 :693 , 2007
PubMedID: 17562316
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice - Tabuchi_2007_Science_318_71
Author(s) : Tabuchi K , Blundell J , Etherton MR , Hammer RE , Liu X , Powell CM , Sudhof TC
Ref : Science , 318 :71 , 2007
PubMedID: 17823315
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : Neurexin-neuroligin signaling in synapse development - Craig_2007_Curr.Opin.Neurobiol_17_43
Author(s) : Craig AM , Kang Y
Ref : Current Opinion in Neurobiology , 17 :43 , 2007
PubMedID: 17275284
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : Medicine. Testing hypotheses about autism -
Author(s) : Crawley JN
Ref : Science , 318 :56 , 2007
PubMedID: 17916718
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : Neurexin Ibeta and neuroligin are localized on opposite membranes in mature central synapses - Berninghausen_2007_J.Neurochem_103_1855
Author(s) : Berninghausen O , Rahman MA , Silva JP , Davletov B , Hopkins C , Ushkaryov YA
Ref : Journal of Neurochemistry , 103 :1855 , 2007
PubMedID: 17868325
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses - Budreck_2007_Eur.J.Neurosci_26_1738
Author(s) : Budreck EC , Scheiffele P
Ref : European Journal of Neuroscience , 26 :1738 , 2007
PubMedID: 17897391
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : Adhesion molecules in the nervous system: structural insights into function and diversity - Shapiro_2007_Annu.Rev.Neurosci_30_451
Author(s) : Shapiro L , Love J , Colman DR
Ref : Annual Review of Neuroscience , 30 :451 , 2007
PubMedID: 17600523
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations - Yamakawa_2007_Biochem.Biophys.Res.Commun_355_41
Author(s) : Yamakawa H , Oyama S , Mitsuhashi H , Sasagawa N , Uchino S , Kohsaka S , Ishiura S
Ref : Biochemical & Biophysical Research Communications , 355 :41 , 2007
PubMedID: 17292328
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients -
Author(s) : Yan J , Oliveira G , Coutinho A , Yang C , Feng J , Katz C , Sram J , Bockholt A , Jones IR , Craddock N , Cook EH, Jr. , Vicente A , Sommer SS
Ref : Mol Psychiatry , 10 :329 , 2005
PubMedID: 15622415
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X

Title : Neuroligins mediate excitatory and inhibitory synapse formation: involvement of PSD-95 and neurexin-1beta in neuroligin-induced synaptic specificity - Levinson_2005_J.Biol.Chem_280_17312
Author(s) : Levinson JN , Chery N , Huang K , Wong TP , Gerrow K , Kang R , Prange O , Wang YT , El-Husseini A
Ref : Journal of Biological Chemistry , 280 :17312 , 2005
PubMedID: 15723836

Title : Selective capability of SynCAM and neuroligin for functional synapse assembly - Sara_2005_J.Neurosci_25_260
Author(s) : Sara Y , Biederer T , Atasoy D , Chubykin AA , Mozhayeva MG , Sudhof TC , Kavalali ET
Ref : Journal of Neuroscience , 25 :260 , 2005
PubMedID: 15634790

Title : Analysis of four neuroligin genes as candidates for autism - Ylisaukko-oja_2005_Eur.J.Hum.Genet_13_1285
Author(s) : Ylisaukko-oja T , Rehnstrom K , Auranen M , Vanhala R , Alen R , Kempas E , Ellonen P , Turunen JA , Makkonen I , Riikonen R , Nieminen-von Wendt T , von Wendt L , Peltonen L , Jarvela I
Ref : Eur J Hum Genet , 13 :1285 , 2005
PubMedID: 16077734
Gene_locus related to this paper: human-NLGN4Y , human-NLGN1 , human-NLGN3 , human-NLGN4X

Title : NLGN3\/NLGN4 gene mutations are not responsible for autism in the Quebec population - Gauthier_2005_Am.J.Med.Genet.B.Neuropsychiatr.Genet_132B_74
Author(s) : Gauthier J , Bonnel A , St-Onge J , Karemera L , Laurent S , Mottron L , Fombonne E , Joober R , Rouleau GA
Ref : American Journal of Medicine Genet B Neuropsychiatr Genet , 132B :74 , 2005
PubMedID: 15389766
Gene_locus related to this paper: human-NLGN4X

Title : Control of excitatory and inhibitory synapse formation by neuroligins - Chih_2005_Science_307_1324
Author(s) : Chih B , Engelman H , Scheiffele P
Ref : Science , 307 :1324 , 2005
PubMedID: 15681343

Title : Do known mutations in neuroligin genes (NLGN3 and NLGN4) cause autism? -
Author(s) : Talebizadeh Z , Bittel DC , Veatch OJ , Butler MG , Takahashi TN , Miles JH
Ref : J Autism Dev Disord , 34 :735 , 2004
PubMedID: 15679194

Title : Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins - Graf_2004_Cell_119_1013
Author(s) : Graf ER , Zhang X , Jin SX , Linhoff MW , Craig AM
Ref : Cell , 119 :1013 , 2004
PubMedID: 15620359

Title : The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing - Comoletti_2004_J.Neurosci_24_4889
Author(s) : Comoletti D , De Jaco A , Jennings LL , Flynn RE , Gaietta G , Tsigelny I , Ellisman MH , Taylor P
Ref : Journal of Neuroscience , 24 :4889 , 2004
PubMedID: 15152050

Title : Synaptic scaffolding molecule is involved in the synaptic clustering of neuroligin - Iida_2004_Mol.Cell.Neurosci_27_497
Author(s) : Iida J , Hirabayashi S , Sato Y , Hata Y
Ref : Molecular & Cellular Neurosciences , 27 :497 , 2004
PubMedID: 15555927

Title : X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family - Laumonnier_2004_Am.J.Hum.Genet_74_552
Author(s) : Laumonnier F , Bonnet-Brilhault F , Gomot M , Blanc R , David A , Moizard MP , Raynaud M , Ronce N , Lemonnier E , Calvas P , Laudier B , Chelly J , Fryns JP , Ropers HH , Hamel BC , Andres C , Barthelemy C , Moraine C , Briault S
Ref : American Journal of Human Genetics , 74 :552 , 2004
PubMedID: 14963808
Gene_locus related to this paper: human-NLGN4X

Title : A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin - Prange_2004_Proc.Natl.Acad.Sci.U.S.A_101_13915
Author(s) : Prange O , Wong TP , Gerrow K , Wang YT , El-Husseini A
Ref : Proc Natl Acad Sci U S A , 101 :13915 , 2004
PubMedID: 15358863

Title : Synaptic targeting of neuroligin is independent of neurexin and SAP90\/PSD95 binding - Dresbach_2004_Mol.Cell.Neurosci_27_227
Author(s) : Dresbach T , Neeb A , Meyer G , Gundelfinger ED , Brose N
Ref : Molecular & Cellular Neurosciences , 27 :227 , 2004
PubMedID: 15519238

Title : Neuroligin 2 is exclusively localized to inhibitory synapses - Varoqueaux_2004_Eur.J.Cell.Biol_83_449
Author(s) : Varoqueaux F , Jamain S , Brose N
Ref : European Journal of Cell Biology , 83 :449 , 2004
PubMedID: 15540461

Title : Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands - Vincent_2004_Am.J.Med.Genet.B.Neuropsychiatr.Genet_129B_82
Author(s) : Vincent JB , Kolozsvari D , Roberts WS , Bolton PF , Gurling HM , Scherer SW
Ref : American Journal of Medicine Genet B Neuropsychiatr Genet , 129B :82 , 2004
PubMedID: 15274046

Title : Synaptic scaffolding molecule interacts with axin - Hirabayashi_2004_J.Neurochem_90_332
Author(s) : Hirabayashi S , Nishimura W , Iida J , Kansaku A , Kishida S , Kikuchi A , Tanaka N , Hata Y
Ref : Journal of Neurochemistry , 90 :332 , 2004
PubMedID: 15228590

Title : Disorder-associated mutations lead to functional inactivation of neuroligins - Chih_2004_Hum.Mol.Genet_13_1471
Author(s) : Chih B , Afridi SK , Clark L , Scheiffele P
Ref : Hum Mol Genet , 13 :1471 , 2004
PubMedID: 15150161

Title : Excessive expression of acetylcholinesterase impairs glutamatergic synaptogenesis in hippocampal neurons - Dong_2004_J.Neurosci_24_8950
Author(s) : Dong H , Xiang YY , Farchi N , Ju W , Wu Y , Chen L , Wang Y , Hochner B , Yang B , Soreq H , Lu WY
Ref : Journal of Neuroscience , 24 :8950 , 2004
PubMedID: 15483114

Title : Structural characterization of recombinant soluble rat neuroligin 1: mapping of secondary structure and glycosylation by mass spectrometry - Hoffman_2004_Biochemistry_43_1496
Author(s) : Hoffman RC , Jennings LL , Tsigelny I , Comoletti D , Flynn RE , Sudhof TC , Taylor P
Ref : Biochemistry , 43 :1496 , 2004
PubMedID: 14769026
Gene_locus related to this paper: ratno-1neur

Title : The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin - Meyer_2004_Neuropharmacol_47_724
Author(s) : Meyer G , Varoqueaux F , Neeb A , Oschlies M , Brose N
Ref : Neuropharmacology , 47 :724 , 2004
PubMedID: 15458844
Gene_locus related to this paper: ratno-1neur

Title : Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta - Comoletti_2003_J.Biol.Chem_278_50497
Author(s) : Comoletti D , Flynn RE , Jennings LL , Chubykin AA , Matsumura T , Hasegawa H , Sudhof TC , Taylor P
Ref : Journal of Biological Chemistry , 278 :50497 , 2003
PubMedID: 14522992

Title : Neurexin mediates the assembly of presynaptic terminals - Dean_2003_Nat.Neurosci_6_708
Author(s) : Dean C , Scholl FG , Choih J , DeMaria S , Berger J , Isacoff E , Scheiffele P
Ref : Nat Neurosci , 6 :708 , 2003
PubMedID: 12796785

Title : Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism - Jamain_2003_Nat.Genet_34_27
Author(s) : Jamain S , Quach H , Betancur C , Rastam M , Colineaux C , Gillberg IC , Soderstrom H , Giros B , Leboyer M , Gillberg C , Bourgeron T
Ref : Nat Genet , 34 :27 , 2003
PubMedID: 12669065
Gene_locus related to this paper: human-NLGN2 , human-NLGN4X , human-NLGN4Y , mouse-4neur , human-NLGN3

Title : Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors - Fu_2003_J.Neurophysiol_90_3950
Author(s) : Fu Z , Washbourne P , Ortinski P , Vicini S
Ref : Journal of Neurophysiology , 90 :3950 , 2003
PubMedID: 12930820

Title : Synaptic adhesion molecules - Yamagata_2003_Curr.Opin.Cell.Biol_15_621
Author(s) : Yamagata M , Sanes JR , Weiner JA
Ref : Current Opinion in Cell Biology , 15 :621 , 2003
PubMedID: 14519398

Title : Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb - Clarris_2002_Int.J.Dev.Biol_46_649
Author(s) : Clarris HJ , McKeown S , Key B
Ref : Int J Developmental Biology , 46 :649 , 2002
PubMedID: 12141453

Title : Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia - Gilbert_2001_Glia_34_151
Author(s) : Gilbert M , Smith J , Roskams AJ , Auld VJ
Ref : Glia , 34 :151 , 2001
PubMedID: 11329178
Gene_locus related to this paper: mouse-3neur , ratno-1neur , ratno-2neur , ratno-3neur

Title : Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression - Bolliger_2001_Biochem.J_356_581
Author(s) : Bolliger MF , Frei K , Winterhalter KH , Gloor SM
Ref : Biochemical Journal , 356 :581 , 2001
PubMedID: 11368788
Gene_locus related to this paper: human-NLGN4X

Title : A stoichiometric complex of neurexins and dystroglycan in brain - Sugita_2001_J.Cell.Biol_154_435
Author(s) : Sugita S , Saito F , Tang J , Satz J , Campbell K , Sudhof TC
Ref : Journal of Cell Biology , 154 :435 , 2001
PubMedID: 11470830

Title : Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons - Scheiffele_2000_Cell_101_657
Author(s) : Scheiffele P , Fan J , Choih J , Fetter R , Serafini T
Ref : Cell , 101 :657 , 2000
PubMedID: 10892652
Gene_locus related to this paper: human-NLGN1 , human-NLGN2

Title : Synapse formation: if it looks like a duck and quacks like a duck - Cantallops_2000_Curr.Biol_10_R620
Author(s) : Cantallops I , Cline HT
Ref : Current Biology , 10 :R620 , 2000
PubMedID: 10996085

Title : The structure and expression of the human neuroligin-3 gene - Philibert_2000_Gene_246_303
Author(s) : Philibert RA , Winfield SL , Sandhu HK , Martin BM , Ginns EI
Ref : Gene , 246 :303 , 2000
PubMedID: 10767552
Gene_locus related to this paper: human-NLGN3

Title : Common EF-hand motifs in cholinesterases and neuroligins suggest a role for Ca2+ binding in cell surface associations - Tsigelny_2000_Protein.Sci_9_180
Author(s) : Tsigelny I , Shindyalov IN , Bourne PE , Sudhof TC , Taylor P
Ref : Protein Science , 9 :180 , 2000
PubMedID: 10739260

Title : Neuroligation: building synapses around the neurexin-neuroligin link -
Author(s) : Rao A , Harms KJ , Craig AM
Ref : Nat Neurosci , 3 :747 , 2000
PubMedID: 10903560

Title : Synaptic cell adhesion proteins and synaptogenesis in the mammalian central nervous system - Brose_1999_Naturwiss_86_516
Author(s) : Brose N
Ref : Naturwissenschaften , 86 :516 , 1999
PubMedID: 10551945

Title : Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses - Song_1999_Proc.Natl.Acad.Sci.U.S.A_96_1100
Author(s) : Song JY , Ichtchenko K , Sudhof TC , Brose N
Ref : Proc Natl Acad Sci U S A , 96 :1100 , 1999
PubMedID: 9927700
Gene_locus related to this paper: ratno-1neur

Title : CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins - Kurschner_1998_Mol.Cell.Neurosci_11_161
Author(s) : Kurschner C , Mermelstein PG , Holden WT , Surmeier DJ
Ref : Molecular & Cellular Neurosciences , 11 :161 , 1998
PubMedID: 9647694

Title : The making of neurexins - Missler_1998_J.Neurochem_71_1339
Author(s) : Missler M , Fernandez-Chacon R , Sudhof TC
Ref : Journal of Neurochemistry , 71 :1339 , 1998
PubMedID: 9751164

Title : Functional redundancy of acetylcholinesterase and neuroligin in mammalian neuritogenesis - Grifman_1998_Proc.Natl.Acad.Sci.U.S.A_95_13935
Author(s) : Grifman M , Galyam N , Seidman S , Soreq H
Ref : Proc Natl Acad Sci U S A , 95 :13935 , 1998
PubMedID: 9811904

Title : Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Ibeta gene expression followed by late-onset neuromotor deterioration - Andres_1997_Proc.Natl.Acad.Sci.U.S.A_94_8173
Author(s) : Andres C , Beeri R , Friedman A , Lev-Lehman E , Henis S , Timberg R , Shani M , Soreq H
Ref : Proc Natl Acad Sci U S A , 94 :8173 , 1997
PubMedID: 9223334

Title : Binding of neuroligins to PSD-95 - Irie_1997_Science_277_1511
Author(s) : Irie M , Hata Y , Takeuchi M , Ichtchenko K , Toyoda A , Hirao K , Takai Y , Rosahl TW , Sudhof TC
Ref : Science , 277 :1511 , 1997
PubMedID: 9278515
Gene_locus related to this paper: human-NLGN1 , human-NLGN2 , human-NLGN3 , human-NLGN4X

Title : Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules - Nguyen_1997_J.Biol.Chem_272_26032
Author(s) : Nguyen T , Sudhof TC
Ref : Journal of Biological Chemistry , 272 :26032 , 1997
PubMedID: 9325340
Gene_locus related to this paper: ratno-1neur

Title : Structures, alternative splicing, and neurexin binding of multiple neuroligins - Ichtchenko_1996_J.Biol.Chem_271_2676
Author(s) : Ichtchenko K , Nguyen T , Sudhof TC
Ref : Journal of Biological Chemistry , 271 :2676 , 1996
PubMedID: 8576240
Gene_locus related to this paper: ratno-1neur , ratno-2neur , ratno-3neur

Title : Neuroligin 1: a splice site-specific ligand for beta-neurexins - Ichtchenko_1995_Cell_81_435
Author(s) : Ichtchenko K , Hata Y , Nguyen T , Ullrich B , Missler M , Moomaw C , Sudhof TC
Ref : Cell , 81 :435 , 1995
PubMedID: 7736595
Gene_locus related to this paper: ratno-1neur , ratno-2neur