Homo sapiens (Human) Neuroligin-4, X-linked (HNLX) Neuroligin4 KIAA0951
Neuronal cell surface protein involved in cell-cell-interactions. Homodimer. Interacts with NRXN1 in a calcium-dependent manner. Interacts through its C-terminus with DLG4\/PSD-95 third PDZ domain. In fact Neuroligin4 is neuroligin X on chromosome X a new entry neuroligin 4Y neuroligin Y is created human-neurxx LOC59203 mRNA in fact identical to 4neur is suppressed || Neuroligin4 mutated in AUTISM, X-LINKED see Jamain et al, Laumonnier et al, Yan et al. see mutation
Family : Neuroligin
Block : C
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMSRPQGLLWL PLLFTPVCVM LNSNVLLWLT ALAIKFTLID SQAQYPVVNT NYGKIRGLRT PLPNEILGPV EQYLGVPYAS PPTGERRFQP PEPPSSWTGI RNTTQFAAVC PQHLDERSLL HDMLPIWFTA NLDTLMTYVQ DQNEDCLYLN IYVPTEDDIH DQNSKKPVMV YIHGGSYMEG TGNMIDGSIL ASYGNVIVIT INYRLGILGF LSTGDQAAKG NYGLLDQIQA LRWIEENVGA FGGDPKRVTI FGSGAGASCV SLLTLSHYSE GLFQKAIIQS GTALSSWAVN YQPAKYTRIL ADKVGCNMLD TTDMVECLRN KNYKELIQQT ITPATYHIAF GPVIDGDVIP DDPQILMEQG EFLNYDIMLG VNQGEGLKFV DGIVDNEDGV TPNDFDFSVS NFVDNLYGYP EGKDTLRETI KFMYTDWADK ENPETRRKTL VALFTDHQWV APAVATADLH AQYGSPTYFY AFYHHCQSEM KPSWADSAHG DEVPYVFGIP MIGPTELFSC NFSKNDVMLS AVVMTYWTNF AKTGDPNQPV PQDTKFIHTK PNRFEEVAWS KYNPKDQLYL HIGLKPRVRD HYRATKVAFW LELVPHLHNL NEIFQYVSTT TKVPPPDMTS FPYGTRRSPA KIWPTTKRPA ITPANNPKHS KDPHKTGPED TTVLIETKRD YSTELSVTIA VGASLLFLNI LAFAALYYKK DKRRHETHRR PSPQRNTTND IAHIQNEEIM SLQMKQLEHD HECESLQAHD TLRLTCPPDY TLTLRRSPDD IPLMTPNTIT MIPNTLTGMQ PLHTFNTFSG GQNSTNLPHG HSTTRV
Title : Phosphorylation of NLGN4X Regulates Spinogenesis and Synaptic Function - Lehr_2025_eNeuro__ |
Author(s) : Lehr AW , Nguyen TA , Han W , Hong E , Badger JD , Lu W , Roche KW |
Ref : eNeuro , : , 2025 |
Abstract : |
PubMedSearch : Lehr_2025_eNeuro__ |
PubMedID: 40032531 |
Gene_locus related to this paper: human-NLGN4X |
Title : The association between NLGN4 gene variants and the incidence of autism spectrum disorders in Guilan, Iran - Atefrad_2025_IBRO.Neurosci.Rep_18_306 |
Author(s) : Atefrad S , Yousefnejad A , Faraji N , Keshavarz P |
Ref : IBRO Neurosci Rep , 18 :306 , 2025 |
Abstract : |
PubMedSearch : Atefrad_2025_IBRO.Neurosci.Rep_18_306 |
PubMedID: 40034542 |
Gene_locus related to this paper: human-NLGN4X |
Title : Late stage melanoma is hallmarked by low NLGN4X expression leading to HIF1A accumulation - Schorghofer_2024_Br.J.Cancer__ |
Author(s) : Schorghofer D , Vock L , Mirea MA , Eckel O , Gschwendtner A , Neesen J , Richtig E , Hengstschlager M , Mikula M |
Ref : Br J Cancer , : , 2024 |
Abstract : |
PubMedSearch : Schorghofer_2024_Br.J.Cancer__ |
PubMedID: 38902533 |
Gene_locus related to this paper: human-NLGN4X |
Title : NLGN4X TCR transgenic T cells to treat gliomas - Kramer_2023_Neuro.Oncol__ |
Author(s) : Kramer C , Kilian M , Chih YC , Kourtesakis A , Hoffmann DC , Boschert T , Koopmann P , Sanghvi K , De Roia A , Jung S , Jahne K , Day B , Shultz LD , Ratliff M , Harbottle R , Green EW , Will R , Wick W , Platten M , Bunse L |
Ref : Neuro Oncol , : , 2023 |
Abstract : |
PubMedSearch : Kramer_2023_Neuro.Oncol__ |
PubMedID: 37715782 |
Gene_locus related to this paper: human-NLGN4X , mouse-4neur |
Title : An Autism-Associated Mutation Impairs Neuroligin-4 Glycosylation and Enhances Excitatory Synaptic Transmission in Human Neurons - Cast_2021_J.Neurosci_41_392 |
Author(s) : Cast TP , Boesch DJ , Smyth K , Shaw AE , Ghebrial M , Chanda S |
Ref : Journal of Neuroscience , 41 :392 , 2021 |
Abstract : |
PubMedSearch : Cast_2021_J.Neurosci_41_392 |
PubMedID: 33268543 |
Gene_locus related to this paper: human-NLGN4X |
Title : Pathogenic paternally inherited NLGN4X deletion in a female with autism spectrum disorder: Clinical, cytogenetic, and molecular characterization - Kopp_2020_Am.J.Med.Genet.A__e62025 |
Author(s) : Kopp N , Amarillo I , Martinez-Agosto J , Quintero-Rivera F |
Ref : American Journal of Medicine Genet A , :e62025 , 2020 |
Abstract : |
PubMedSearch : Kopp_2020_Am.J.Med.Genet.A__e62025 |
PubMedID: 33369065 |
Gene_locus related to this paper: human-NLGN4X |
Title : Elevated plasma X-linked neuroligin 4 expression is associated with autism spectrum disorder - Alayadhi_2020_Med.Princ.Pract__ |
Author(s) : Alayadhi LY , Qasem H , Alghamdi HAM , Elamin NE |
Ref : Med Princ Pract , : , 2020 |
Abstract : |
PubMedSearch : Alayadhi_2020_Med.Princ.Pract__ |
PubMedID: 32155636 |
Gene_locus related to this paper: human-NLGN4X |
Title : A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y - Nguyen_2020_Neuron_106_759 |
Author(s) : Nguyen TA , Wu K , Pandey S , Lehr AW , Li Y , Bemben MA , Badger JD, 2nd , Lauzon JL , Wang T , Zaghloul KA , Thurm A , Jain M , Lu W , Roche KW |
Ref : Neuron , 106 :759 , 2020 |
Abstract : |
PubMedSearch : Nguyen_2020_Neuron_106_759 |
PubMedID: 32243781 |
Gene_locus related to this paper: human-NLGN4X , human-NLGN4Y |
Title : Analysis of the SNP rs3747333 and rs3747334 in NLGN4X gene in autism spectrum disorder: a meta-analysis - Sun_2019_Ann.Gen.Psychiatry_18_6 |
Author(s) : Sun H , Yang Y , Zhang L , Wu H , Zhang H , Li H |
Ref : Ann Gen Psychiatry , 18 :6 , 2019 |
Abstract : |
PubMedSearch : Sun_2019_Ann.Gen.Psychiatry_18_6 |
PubMedID: 31139237 |
Gene_locus related to this paper: human-NLGN4X |
Title : Not all neuroligin 3 and 4X missense variants lead to significant functional inactivation - Xu_2017_Brain.Behav_7_e00793 |
Author(s) : Xu X , Hu Z , Zhang L , Liu H , Cheng Y , Xia K , Zhang X |
Ref : Brain Behav , 7 :e00793 , 2017 |
Abstract : |
PubMedSearch : Xu_2017_Brain.Behav_7_e00793 |
PubMedID: 28948087 |
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
Title : Neuroligin 4X overexpression in human breast cancer is associated with poor relapse-free survival - Henderson_2017_PLoS.One_12_e0189662 |
Author(s) : Henderson HJ , Karanam B , Samant R , Vig K , Singh SR , Yates C , Bedi D |
Ref : PLoS ONE , 12 :e0189662 , 2017 |
Abstract : |
PubMedSearch : Henderson_2017_PLoS.One_12_e0189662 |
PubMedID: 29244827 |
Gene_locus related to this paper: human-NLGN4X |
Title : Variations analysis of NLGN3 and NLGN4X gene in Chinese autism patients - Xu_2014_Mol.Biol.Rep_41_4133 |
Author(s) : Xu X , Xiong Z , Zhang L , Liu Y , Lu L , Peng Y , Guo H , Zhao J , Xia K , Hu Z |
Ref : Mol Biol Rep , 41 :4133 , 2014 |
Abstract : |
PubMedSearch : Xu_2014_Mol.Biol.Rep_41_4133 |
PubMedID: 24570023 |
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
Title : Analysis of the genes encoding neuroligins NLGN3 and NLGN4 in Bulgarian patients with autism - Avdjieva-Tzavella_2012_Genet.Couns_23_505 |
Author(s) : Avdjieva-Tzavella DM , Todorov TP , Todorova AP , Kirov AV , Hadjidekova SP , Rukova BB , Litvinenko IO , Hristova-Naydenova DN , Tincheva RS , Toncheva DI |
Ref : Genet Couns , 23 :505 , 2012 |
Abstract : |
PubMedSearch : Avdjieva-Tzavella_2012_Genet.Couns_23_505 |
PubMedID: 23431752 |
Gene_locus related to this paper: human-NLGN4X |
Title : Structural insights into the exquisite selectivity of neurexin\/neuroligin synaptic interactions - Leone_2010_EMBO.J_29_2461 |
Author(s) : Leone P , Comoletti D , Ferracci G , Conrod S , Garcia SU , Taylor P , Bourne Y , Marchot P |
Ref : EMBO Journal , 29 :2461 , 2010 |
Abstract : |
PubMedSearch : Leone_2010_EMBO.J_29_2461 |
PubMedID: 20543817 |
Gene_locus related to this paper: human-NLGN4X |
Title : No evidence for involvement of genetic variants in the X-linked neuroligin genes NLGN3 and NLGN4X in probands with autism spectrum disorder on high functioning level - Wermter_2008_Am.J.Med.Genet.B.Neuropsychiatr.Genet_147B_535 |
Author(s) : Wermter AK , Kamp-Becker I , Strauch K , Schulte-Korne G , Remschmidt H |
Ref : American Journal of Medicine Genet B Neuropsychiatr Genet , 147B :535 , 2008 |
Abstract : |
PubMedSearch : Wermter_2008_Am.J.Med.Genet.B.Neuropsychiatr.Genet_147B_535 |
PubMedID: 18189281 |
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
Title : Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses - Budreck_2007_Eur.J.Neurosci_26_1738 |
Author(s) : Budreck EC , Scheiffele P |
Ref : European Journal of Neuroscience , 26 :1738 , 2007 |
Abstract : |
PubMedSearch : Budreck_2007_Eur.J.Neurosci_26_1738 |
PubMedID: 17897391 |
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
Title : Adhesion molecules in the nervous system: structural insights into function and diversity - Shapiro_2007_Annu.Rev.Neurosci_30_451 |
Author(s) : Shapiro L , Love J , Colman DR |
Ref : Annual Review of Neuroscience , 30 :451 , 2007 |
Abstract : |
PubMedSearch : Shapiro_2007_Annu.Rev.Neurosci_30_451 |
PubMedID: 17600523 |
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
Title : Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations - Yamakawa_2007_Biochem.Biophys.Res.Commun_355_41 |
Author(s) : Yamakawa H , Oyama S , Mitsuhashi H , Sasagawa N , Uchino S , Kohsaka S , Ishiura S |
Ref : Biochemical & Biophysical Research Communications , 355 :41 , 2007 |
Abstract : |
PubMedSearch : Yamakawa_2007_Biochem.Biophys.Res.Commun_355_41 |
PubMedID: 17292328 |
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
Title : Neuroscience. Autism's cause may reside in abnormalities at the synapse - |
Author(s) : Garber K |
Ref : Science , 317 :190 , 2007 |
PubMedID: 17626859 |
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
Title : Synaptic arrangement of the neuroligin\/beta-neurexin complex revealed by X-ray and neutron scattering - Comoletti_2007_Structure_15_693 |
Author(s) : Comoletti D , Grishaev A , Whitten AE , Tsigelny I , Taylor P , Trewhella J |
Ref : Structure , 15 :693 , 2007 |
Abstract : |
PubMedSearch : Comoletti_2007_Structure_15_693 |
PubMedID: 17562316 |
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
Title : A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice - Tabuchi_2007_Science_318_71 |
Author(s) : Tabuchi K , Blundell J , Etherton MR , Hammer RE , Liu X , Powell CM , Sudhof TC |
Ref : Science , 318 :71 , 2007 |
Abstract : |
PubMedSearch : Tabuchi_2007_Science_318_71 |
PubMedID: 17823315 |
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
Title : Neurexin-neuroligin signaling in synapse development - Craig_2007_Curr.Opin.Neurobiol_17_43 |
Author(s) : Craig AM , Kang Y |
Ref : Current Opinion in Neurobiology , 17 :43 , 2007 |
Abstract : |
PubMedSearch : Craig_2007_Curr.Opin.Neurobiol_17_43 |
PubMedID: 17275284 |
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
Title : Medicine. Testing hypotheses about autism - |
Author(s) : Crawley JN |
Ref : Science , 318 :56 , 2007 |
PubMedID: 17916718 |
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
Title : Neurexin Ibeta and neuroligin are localized on opposite membranes in mature central synapses - Berninghausen_2007_J.Neurochem_103_1855 |
Author(s) : Berninghausen O , Rahman MA , Silva JP , Davletov B , Hopkins C , Ushkaryov YA |
Ref : Journal of Neurochemistry , 103 :1855 , 2007 |
Abstract : |
PubMedSearch : Berninghausen_2007_J.Neurochem_103_1855 |
PubMedID: 17868325 |
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
Title : Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion - Fabrichny_2007_Neuron_56_979 |
Author(s) : Fabrichny IP , Leone P , Sulzenbacher G , Comoletti D , Miller MT , Taylor P , Bourne Y , Marchot P |
Ref : Neuron , 56 :979 , 2007 |
Abstract : |
PubMedSearch : Fabrichny_2007_Neuron_56_979 |
PubMedID: 18093521 |
Gene_locus related to this paper: human-NLGN4X |
Title : NLGN3\/NLGN4 gene mutations are not responsible for autism in the Quebec population - Gauthier_2005_Am.J.Med.Genet.B.Neuropsychiatr.Genet_132B_74 |
Author(s) : Gauthier J , Bonnel A , St-Onge J , Karemera L , Laurent S , Mottron L , Fombonne E , Joober R , Rouleau GA |
Ref : American Journal of Medicine Genet B Neuropsychiatr Genet , 132B :74 , 2005 |
Abstract : |
PubMedSearch : Gauthier_2005_Am.J.Med.Genet.B.Neuropsychiatr.Genet_132B_74 |
PubMedID: 15389766 |
Gene_locus related to this paper: human-NLGN4X |
Title : Analysis of four neuroligin genes as candidates for autism - Ylisaukko-oja_2005_Eur.J.Hum.Genet_13_1285 |
Author(s) : Ylisaukko-oja T , Rehnstrom K , Auranen M , Vanhala R , Alen R , Kempas E , Ellonen P , Turunen JA , Makkonen I , Riikonen R , Nieminen-von Wendt T , von Wendt L , Peltonen L , Jarvela I |
Ref : Eur J Hum Genet , 13 :1285 , 2005 |
Abstract : |
PubMedSearch : Ylisaukko-oja_2005_Eur.J.Hum.Genet_13_1285 |
PubMedID: 16077734 |
Gene_locus related to this paper: human-NLGN4Y , human-NLGN1 , human-NLGN3 , human-NLGN4X |
Title : Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients - |
Author(s) : Yan J , Oliveira G , Coutinho A , Yang C , Feng J , Katz C , Sram J , Bockholt A , Jones IR , Craddock N , Cook EH, Jr. , Vicente A , Sommer SS |
Ref : Mol Psychiatry , 10 :329 , 2005 |
PubMedID: 15622415 |
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X |
Title : X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family - Laumonnier_2004_Am.J.Hum.Genet_74_552 |
Author(s) : Laumonnier F , Bonnet-Brilhault F , Gomot M , Blanc R , David A , Moizard MP , Raynaud M , Ronce N , Lemonnier E , Calvas P , Laudier B , Chelly J , Fryns JP , Ropers HH , Hamel BC , Andres C , Barthelemy C , Moraine C , Briault S |
Ref : American Journal of Human Genetics , 74 :552 , 2004 |
Abstract : |
PubMedSearch : Laumonnier_2004_Am.J.Hum.Genet_74_552 |
PubMedID: 14963808 |
Gene_locus related to this paper: human-NLGN4X |
Title : Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism - Jamain_2003_Nat.Genet_34_27 |
Author(s) : Jamain S , Quach H , Betancur C , Rastam M , Colineaux C , Gillberg IC , Soderstrom H , Giros B , Leboyer M , Gillberg C , Bourgeron T |
Ref : Nat Genet , 34 :27 , 2003 |
Abstract : |
PubMedSearch : Jamain_2003_Nat.Genet_34_27 |
PubMedID: 12669065 |
Gene_locus related to this paper: human-NLGN2 , human-NLGN4X , human-NLGN4Y , mouse-4neur , human-NLGN3 |
Title : Identification of a novel neuroligin in humans which binds to PSD-95 and has a widespread expression - Bolliger_2001_Biochem.J_356_581 |
Author(s) : Bolliger MF , Frei K , Winterhalter KH , Gloor SM |
Ref : Biochemical Journal , 356 :581 , 2001 |
Abstract : |
PubMedSearch : Bolliger_2001_Biochem.J_356_581 |
PubMedID: 11368788 |
Gene_locus related to this paper: human-NLGN4X |
Title : Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro - Nagase_1999_DNA.Res_6_337 |
Author(s) : Nagase T , Ishikawa K , Kikuno R , Hirosawa M , Nomura N , Ohara O |
Ref : DNA Research , 6 :337 , 1999 |
Abstract : |
PubMedSearch : Nagase_1999_DNA.Res_6_337 |
PubMedID: 10574462 |
Gene_locus related to this paper: human-NDRG2 , human-NLGN4X |
Title : Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro - Nagase_1999_DNA.Res_6_63 |
Author(s) : Nagase T , Ishikawa K , Suyama M , Kikuno R , Hirosawa M , Miyajima N , Tanaka A , Kotani H , Nomura N , Ohara O |
Ref : DNA Research , 6 :63 , 1999 |
Abstract : |
PubMedSearch : Nagase_1999_DNA.Res_6_63 |
PubMedID: 10231032 |
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X , human-NLGN4Y |
Title : Binding of neuroligins to PSD-95 - Irie_1997_Science_277_1511 |
Author(s) : Irie M , Hata Y , Takeuchi M , Ichtchenko K , Toyoda A , Hirao K , Takai Y , Rosahl TW , Sudhof TC |
Ref : Science , 277 :1511 , 1997 |
Abstract : |
PubMedSearch : Irie_1997_Science_277_1511 |
PubMedID: 9278515 |
Gene_locus related to this paper: human-NLGN1 , human-NLGN2 , human-NLGN3 , human-NLGN4X |