| Title : Electrophoretically mediated microanalysis technique as a tool for the rapid screening of novel acetylcholinesterase inhibitors - Bajda_2009_Acta.Pol.Pharm_66_357 |
| Author(s) : Bajda M , Wieckowska A , Malawska B |
| Ref : Acta Pol Pharm , 66 :357 , 2009 |
|
Abstract :
An electrophoretically mediated microanalysis technique was developed for the rapid screening of acetylcholinesterase inhibitors. Activity of four original compounds, N-benzylpiperidine, carbamoyloxyphenyl derivatives and reference inhibitor--tacrine was determined and compared with the data obtained from Ellman's assay. Percentage of enzyme inhibition detected at inhibitor concentration of 3.33.10(-4) M was between 0 and 78% and was the highest for tacrine. The comparison of data obtained from the EMMA assay and Ellman's test proved inhibitory activity of novel compounds. |
| PubMedSearch : Bajda_2009_Acta.Pol.Pharm_66_357 |
| PubMedID: 19702166 |
Bajda M, Wieckowska A, Malawska B (2009)
Electrophoretically mediated microanalysis technique as a tool for the rapid screening of novel acetylcholinesterase inhibitors
Acta Pol Pharm
66 :357
Bajda M, Wieckowska A, Malawska B (2009)
Acta Pol Pharm
66 :357