| Title : Preliminary studies of 1,5-benzoxazepine derivatives as potential histamine H(3) receptor antagonists - Stefaniak-Napieralska_2024_Future.Med.Chem__ |
| Author(s) : Stefaniak-Napieralska M , Walczynski K , Iwan M , Korga-Plewko A , Szalaj N , Wieckowska A , Staszewski M |
| Ref : Future Med Chem , : , 2024 |
| Abstract : |
| PubMedSearch : Stefaniak-Napieralska_2024_Future.Med.Chem__ |
| PubMedID: 38189171 |
| Title : Multifunctional, fluorene-based modulator of cholinergic and GABAergic neurotransmission as a novel drug candidate for palliative treatment of Alzheimer's disease - Panek_2024_Angew.Chem.Int.Ed.Engl__e202420510 |
| Author(s) : Panek D , Pasieka A , Jonczyk JJ , Gawlinska M , Zareba P , Siwek A , Wolak M , Mordyl B , Gluch-Lutwin M , Latacz G , Brazzolotto X , Chantegreil F , Nachon F , Zdarova Karasova J , Pejchal J , Mzik M , Sestak V , Prchal L , Odvarkova J , Soukup O , Korabecny J , Sorf A , Hamsikova M , Zemanova L , Muckova L , Vanova N , Dryja P , Salat K , Hofner G , Wanner K , Wieckowska A , Malawska B |
| Ref : Angew Chem Int Ed Engl , :e202420510 , 2024 |
| Abstract : |
| PubMedSearch : Panek_2024_Angew.Chem.Int.Ed.Engl__e202420510 |
| PubMedID: 39523866 |
| Gene_locus related to this paper: human-BCHE |
| Title : Discovery of New Highly Potent Histamine H(3) Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors - Malek_2024_ACS.Chem.Neurosci__ |
| Author(s) : Malek R , Salat K , Totoson P , Karcz T , Refouvelet B , Skrzypczak-Wiercioch A , Maj M , Simakov A , Martin H , Siwek A , Szalaj N , Godyn J , Panek D , Wieckowska A , Jozwiak K , Demougeot C , Kiec-Kononowicz K , Chabchoub F , Iriepa I , Marco-Contelles J , Ismaili L |
| Ref : ACS Chem Neurosci , : , 2024 |
| Abstract : |
| PubMedSearch : Malek_2024_ACS.Chem.Neurosci__ |
| PubMedID: 39208251 |
| Title : 4-Oxypiperidine Ethers as Multiple Targeting Ligands at Histamine H(3) Receptors and Cholinesterases - Michalska_2024_ACS.Chem.Neurosci__ |
| Author(s) : Michalska B , Dziegielewski M , Godyn J , Werner T , Bajda M , Karcz T , Szczepanska K , Stark H , Wieckowska A , Walczynski K , Staszewski M |
| Ref : ACS Chem Neurosci , : , 2024 |
| Abstract : |
| PubMedSearch : Michalska_2024_ACS.Chem.Neurosci__ |
| PubMedID: 38440987 |
| Title : Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and beta-amyloid inhibitors for the treatment of Alzheimer's disease - Pasieka_2023_Bioorg.Med.Chem_88-89_117333 |
| Author(s) : Pasieka A , Panek D , Zareba P , Slugocka E , Gucwa N , Espargaro A , Latacz G , Khan N , Bucki A , Sabate R , Wieckowska A , Malawska B |
| Ref : Bioorganic & Medicinal Chemistry , 88-89 :117333 , 2023 |
| Abstract : |
| PubMedSearch : Pasieka_2023_Bioorg.Med.Chem_88-89_117333 |
| PubMedID: 37236021 |
| Title : Guanidines: Synthesis of Novel Histamine H(3)R Antagonists with Additional Breast Anticancer Activity and Cholinesterases Inhibitory Effect - Staszewski_2023_Pharmaceuticals.(Basel)_16_ |
| Author(s) : Staszewski M , Iwan M , Werner T , Bajda M , Godyn J , Latacz G , Korga-Plewko A , Kubik J , Szalaj N , Stark H , Malawska B , Wieckowska A , Walczynski K |
| Ref : Pharmaceuticals (Basel) , 16 : , 2023 |
| Abstract : |
| PubMedSearch : Staszewski_2023_Pharmaceuticals.(Basel)_16_ |
| PubMedID: 37242458 |
| Title : Discovery of new, highly potent and selective inhibitors of BuChE - Design, synthesis, in vitro and in vivo evaluation and crystallography studies - Panek_2023_Eur.J.Med.Chem_249_115135 |
| Author(s) : Panek D , Pasieka A , Latacz G , Zareba P , Szczech M , Godyn J , Chantegreil F , Nachon F , Brazzolotto X , Skrzypczak-Wiercioch A , Walczak M , Smolik M , Salat K , Hofner G , Wanner K , Wieckowska A , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 249 :115135 , 2023 |
| Abstract : |
| PubMedSearch : Panek_2023_Eur.J.Med.Chem_249_115135 |
| PubMedID: 36696766 |
| Gene_locus related to this paper: human-BCHE |
| Title : Multitargeting Histamine H(3) Receptor Ligands among Acetyl- and Propionyl-Phenoxyalkyl Derivatives - Lazewska_2023_Molecules_28_ |
| Author(s) : Lazewska D , Kaleta M , Zareba P , Godyn J , Dubiel M , Honkisz-Orzechowska E , Doroz-Plonka A , Wieckowska A , Stark H , Kiec-Kononowicz K |
| Ref : Molecules , 28 : , 2023 |
| Abstract : |
| PubMedSearch : Lazewska_2023_Molecules_28_ |
| PubMedID: 36903593 |
| Title : Benzophenone Derivatives with Histamine H(3) Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease - Godyn_2022_Molecules_28_ |
| Author(s) : Godyn J , Zareba P , Stary D , Kaleta M , Kuder KJ , Latacz G , Mogilski S , Reiner-Link D , Frank A , Doroz-Plonka A , Olejarz-Maciej A , Sudol-Talaj S , Nolte T , Handzlik J , Stark H , Wieckowska A , Malawska B , Kiec-Kononowicz K , Lazewska D , Bajda M |
| Ref : Molecules , 28 : , 2022 |
| Abstract : |
| PubMedSearch : Godyn_2022_Molecules_28_ |
| PubMedID: 36615435 |
| Title : Serotonin 5-HT(6) Receptor Ligands and Butyrylcholinesterase Inhibitors Displaying Antioxidant Activity-Design, Synthesis and Biological Evaluation of Multifunctional Agents against Alzheimer's Disease - Wieckowski_2022_Int.J.Mol.Sci_23_9443 |
| Author(s) : Wieckowski K , Szalaj N , Gryzlo B , Wichur T , Goral I , Slugocka E , Sniecikowska J , Latacz G , Siwek A , Godyn J , Bucki A , Kolaczkowski M , Wieckowska A |
| Ref : Int J Mol Sci , 23 : , 2022 |
| Abstract : |
| PubMedSearch : Wieckowski_2022_Int.J.Mol.Sci_23_9443 |
| PubMedID: 36012707 |
| Title : Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with beta-amyloid anti-aggregation properties - Wichur_2021_Eur.J.Med.Chem_225_113792 |
| Author(s) : Wichur T , Godyn J , Goral I , Latacz G , Bucki A , Siwek A , Gluch-Lutwin M , Mordyl B , Sniecikowska J , Walczak M , Knez D , Jukic M , Salat K , Gobec S , Kolaczkowski M , Malawska B , Brazzolotto X , Wieckowska A |
| Ref : Eur Journal of Medicinal Chemistry , 225 :113792 , 2021 |
| Abstract : |
| PubMedSearch : Wichur_2021_Eur.J.Med.Chem_225_113792 |
| PubMedID: 34530376 |
| Gene_locus related to this paper: human-BCHE |
| Title : Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT(6) receptor with anti-aggregation properties against amyloid-beta and tau - Wichur_2021_Eur.J.Med.Chem_225_113783 |
| Author(s) : Wichur T , Pasieka A , Godyn J , Panek D , Goral I , Latacz G , Honkisz-Orzechowska E , Bucki A , Siwek A , Gluch-Lutwin M , Knez D , Brazzolotto X , Gobec S , Kolaczkowski M , Sabate R , Malawska B , Wieckowska A |
| Ref : Eur Journal of Medicinal Chemistry , 225 :113783 , 2021 |
| Abstract : |
| PubMedSearch : Wichur_2021_Eur.J.Med.Chem_225_113783 |
| PubMedID: 34461507 |
| Title : Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease - Szalaj_2020_J.Enzyme.Inhib.Med.Chem_35_1944 |
| Author(s) : Szalaj N , Godyn J , Jonczyk J , Pasieka A , Panek D , Wichur T , Wieckowski K , Zareba P , Bajda M , Pislar A , Malawska B , Sabate R , Wieckowska A |
| Ref : J Enzyme Inhib Med Chem , 35 :1944 , 2020 |
| Abstract : |
| PubMedSearch : Szalaj_2020_J.Enzyme.Inhib.Med.Chem_35_1944 |
| PubMedID: 33092411 |
| Title : Anti-Alzheimer's multitarget-directed ligands with serotonin 5-HT6 antagonist, butyrylcholinesterase inhibitory, and antioxidant activity - Marcinkowska_2019_Arch.Pharm.(Weinheim)__e1900041 |
| Author(s) : Marcinkowska M , Bucki A , Panek D , Siwek A , Fajkis N , Bednarski M , Zygmunt M , Godyn J , Del Rio Valdivieso A , Kotanska M , Kolaczkowski M , Wieckowska A |
| Ref : Arch Pharm (Weinheim) , :e1900041 , 2019 |
| Abstract : |
| PubMedSearch : Marcinkowska_2019_Arch.Pharm.(Weinheim)__e1900041 |
| PubMedID: 31162703 |
| Title : 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease - Wichur_2019_Eur.J.Med.Chem_187_111916 |
| Author(s) : Wichur T , Wieckowska A , Wieckowski K , Godyn J , Jonczyk J , Valdivieso ADR , Panek D , Pasieka A , Sabate R , Knez D , Gobec S , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 187 :111916 , 2019 |
| Abstract : |
| PubMedSearch : Wichur_2019_Eur.J.Med.Chem_187_111916 |
| PubMedID: 31812794 |
| Title : Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer's Disease - Wieckowska_2018_ACS.Chem.Neurosci_9_1195 |
| Author(s) : Wieckowska A , Wichur T , Godyn J , Bucki A , Marcinkowska M , Siwek A , Wieckowski K , Zareba P , Knez D , Gluch-Lutwin M , Kazek G , Latacz G , Mika K , Kolaczkowski M , Korabecny J , Soukup O , Benkova M , Kiec-Kononowicz K , Gobec S , Malawska B |
| Ref : ACS Chem Neurosci , 9 :1195 , 2018 |
| Abstract : |
| PubMedSearch : Wieckowska_2018_ACS.Chem.Neurosci_9_1195 |
| PubMedID: 29384656 |
| Title : Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents - Panek_2018_Molecules_23_ |
| Author(s) : Panek D , Wieckowska A , Pasieka A , Godyn J , Jonczyk J , Bajda M , Knez D , Gobec S , Malawska B |
| Ref : Molecules , 23 : , 2018 |
| Abstract : |
| PubMedSearch : Panek_2018_Molecules_23_ |
| PubMedID: 29414887 |
| Title : Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents - Panek_2018_ACS.Chem.Neurosci_9_1074 |
| Author(s) : Panek D , Wieckowska A , Jonczyk J , Godyn J , Bajda M , Wichur T , Pasieka A , Knez D , Pislar A , Korabecny J , Soukup O , Sepsova V , Sabate R , Kos J , Gobec S , Malawska B |
| Ref : ACS Chem Neurosci , 9 :1074 , 2018 |
| Abstract : |
| PubMedSearch : Panek_2018_ACS.Chem.Neurosci_9_1074 |
| PubMedID: 29345897 |
| Title : Lipophilic properties of anti-Alzheimer's agents determined by micellar electrokinetic chromatography and reversed-phase thin-layer chromatography - Godyn_2017_Electrophoresis_38_1268 |
| Author(s) : Godyn J , Hebda M , Wieckowska A , Wieckowski K , Malawska B , Bajda M |
| Ref : Electrophoresis , 38 :1268 , 2017 |
| Abstract : |
| PubMedSearch : Godyn_2017_Electrophoresis_38_1268 |
| PubMedID: 28169440 |
| Title : Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation - Panek_2016_Eur.J.Med.Chem_125_676 |
| Author(s) : Panek D , Wieckowska A , Wichur T , Bajda M , Godyn J , Jonczyk J , Mika K , Janockova J , Soukup O , Knez D , Korabecny J , Gobec S , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 125 :676 , 2016 |
| Abstract : |
| PubMedSearch : Panek_2016_Eur.J.Med.Chem_125_676 |
| PubMedID: 27721153 |
| Title : Development of an in-vivo active reversible butyrylcholinesterase inhibitor - Kosak_2016_Sci.Rep_6_39495 |
| Author(s) : Kosak U , Brus B , Knez D , Sink R , Zakelj S , Trontelj J , Pislar A , Slenc J , Gobec M , Zivin M , Tratnjek L , Perse M , Salat K , Podkowa A , Filipek B , Nachon F , Brazzolotto X , Wieckowska A , Malawska B , Stojan J , Rascan IM , Kos J , Coquelle N , Colletier JP , Gobec S |
| Ref : Sci Rep , 6 :39495 , 2016 |
| Abstract : |
| PubMedSearch : Kosak_2016_Sci.Rep_6_39495 |
| PubMedID: 28000737 |
| Gene_locus related to this paper: human-BCHE |
| Title : Cholinesterase inhibitory activity of chlorophenoxy derivatives-Histamine H3 receptor ligands - Lazewska_2016_Bioorg.Med.Chem.Lett_26_4140 |
| Author(s) : Lazewska D , Jonczyk J , Bajda M , Szalaj N , Wieckowska A , Panek D , Moore C , Kuder K , Malawska B , Kiec-Kononowicz K |
| Ref : Bioorganic & Medicinal Chemistry Lett , 26 :4140 , 2016 |
| Abstract : |
| PubMedSearch : Lazewska_2016_Bioorg.Med.Chem.Lett_26_4140 |
| PubMedID: 27445168 |
| Title : Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation - Wieckowska_2016_Eur.J.Med.Chem_124_63 |
| Author(s) : Wieckowska A , Kolaczkowski M , Bucki A , Godyn J , Marcinkowska M , Wieckowski K , Zareba P , Siwek A , Kazek G , Gluch-Lutwin M , Mierzejewski P , Bienkowski P , Sienkiewicz-Jarosz H , Knez D , Wichur T , Gobec S , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 124 :63 , 2016 |
| Abstract : |
| PubMedSearch : Wieckowska_2016_Eur.J.Med.Chem_124_63 |
| PubMedID: 27560283 |
| Title : Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta - Hebda_2016_Molecules_21_ |
| Author(s) : Hebda M , Bajda M , Wieckowska A , Szalaj N , Pasieka A , Panek D , Godyn J , Wichur T , Knez D , Gobec S , Malawska B |
| Ref : Molecules , 21 : , 2016 |
| Abstract : |
| PubMedSearch : Hebda_2016_Molecules_21_ |
| PubMedID: 27023510 |
| Title : Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with beta-amyloid anti-aggregation properties and beneficial effects on memory in vivo - Wieckowska_2015_Bioorg.Med.Chem_23_2445 |
| Author(s) : Wieckowska A , Wieckowski K , Bajda M , Brus B , Salat K , Czerwinska P , Gobec S , Filipek B , Malawska B |
| Ref : Bioorganic & Medicinal Chemistry , 23 :2445 , 2015 |
| Abstract : |
| PubMedSearch : Wieckowska_2015_Bioorg.Med.Chem_23_2445 |
| PubMedID: 25868744 |
| Title : SEARCH FOR POTENTIAL CHOLINESTERASE INHIBITORS FROM THE ZINC DATABASE BY VIRTUAL SCREENING METHOD - Bajda_2015_Acta.Pol.Pharm_72_737 |
| Author(s) : Bajda M , Panek D , Hebda M , Wieckowska A , Guzior N , Malawska B |
| Ref : Acta Pol Pharm , 72 :737 , 2015 |
| Abstract : |
| PubMedSearch : Bajda_2015_Acta.Pol.Pharm_72_737 |
| PubMedID: 26647631 |
| Title : Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease - Guzior_2015_Curr.Med.Chem_22_373 |
| Author(s) : Guzior N , Wieckowska A , Panek D , Malawska B |
| Ref : Curr Med Chem , 22 :373 , 2015 |
| Abstract : |
| PubMedSearch : Guzior_2015_Curr.Med.Chem_22_373 |
| PubMedID: 25386820 |
| Title : Structure-based search for new inhibitors of cholinesterases - Bajda_2013_Int.J.Mol.Sci_14_5608 |
| Author(s) : Bajda M , Wieckowska A , Hebda M , Guzior N , Sotriffer CA , Malawska B |
| Ref : Int J Mol Sci , 14 :5608 , 2013 |
| Abstract : |
| PubMedSearch : Bajda_2013_Int.J.Mol.Sci_14_5608 |
| PubMedID: 23478436 |
| Title : Novel alkyl- and arylcarbamate derivatives with N-benzylpiperidine and N-benzylpiperazine moieties as cholinesterases inhibitors - Wieckowska_2010_Eur.J.Med.Chem_45_5602 |
| Author(s) : Wieckowska A , Bajda M , Guzior N , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 45 :5602 , 2010 |
| Abstract : |
| PubMedSearch : Wieckowska_2010_Eur.J.Med.Chem_45_5602 |
| PubMedID: 20926161 |
| Title : Electrophoretically mediated microanalysis technique as a tool for the rapid screening of novel acetylcholinesterase inhibitors - Bajda_2009_Acta.Pol.Pharm_66_357 |
| Author(s) : Bajda M , Wieckowska A , Malawska B |
| Ref : Acta Pol Pharm , 66 :357 , 2009 |
| Abstract : |
| PubMedSearch : Bajda_2009_Acta.Pol.Pharm_66_357 |
| PubMedID: 19702166 |