Title : Modifications of human carboxylesterase for improved prodrug activation - Hatfield_2008_Expert.Opin.Drug.Metab.Toxicol_4_1153 |
Author(s) : Hatfield JM , Wierdl M , Wadkins RM , Potter PM |
Ref : Expert Opin Drug Metab Toxicol , 4 :1153 , 2008 |
Abstract :
BACKGROUND: Carboxylesterases (CEs) are ubiquitous enzymes responsible for the hydrolysis of numerous clinically useful drugs. As ester moieties are frequently included in molecules to improve their water solubility and bioavailability, de facto they become substrates for CEs. OBJECTIVE: In this review, we describe the properties of human CEs with regard to their ability to activate anticancer prodrugs and demonstrate how structure-based design can be used to modulate substrate specificity and to increase efficiency of hydrolysis. |
PubMedSearch : Hatfield_2008_Expert.Opin.Drug.Metab.Toxicol_4_1153 |
PubMedID: 18721110 |
Hatfield JM, Wierdl M, Wadkins RM, Potter PM (2008)
Modifications of human carboxylesterase for improved prodrug activation
Expert Opin Drug Metab Toxicol
4 :1153
Hatfield JM, Wierdl M, Wadkins RM, Potter PM (2008)
Expert Opin Drug Metab Toxicol
4 :1153