| Title : Insights and Ideas Garnered from Marine Metabolites for Development of Dual-Function Acetylcholinesterase and Amyloid-beta Aggregation Inhibitors - Stoddard_2014_Mar.Drugs_12_2114 |
| Author(s) : Stoddard SV , Hamann MT , Wadkins RM |
| Ref : Mar Drugs , 12 :2114 , 2014 |
| Abstract : |
| PubMedSearch : Stoddard_2014_Mar.Drugs_12_2114 |
| PubMedID: 24714126 |
| Title : Global and local molecular dynamics of a bacterial carboxylesterase provide insight into its catalytic mechanism - Yu_2012_J.Mol.Model_18_2869 |
| Author(s) : Yu X , Sigler SC , Hossain D , Wierdl M , Gwaltney SR , Potter PM , Wadkins RM |
| Ref : J Mol Model , 18 :2869 , 2012 |
| Abstract : |
| PubMedSearch : Yu_2012_J.Mol.Model_18_2869 |
| PubMedID: 22127613 |
| Title : In silico design and evaluation of carboxylesterase inhibitors - Stoddard_2010_J.Pestic.Sci_35_240 |
| Author(s) : Stoddard SV , Yu X , Potter PM , Wadkins RM |
| Ref : Journal of Pesticide Science , 35 :240 , 2010 |
| Abstract : |
| PubMedSearch : Stoddard_2010_J.Pestic.Sci_35_240 |
| PubMedID: |
| Title : Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin - Hatfield_2010_Br.J.Pharmacol_160_1916 |
| Author(s) : Hatfield MJ , Tsurkan LG , Hyatt JL , Yu X , Edwards CC , Hicks LD , Wadkins RM , Potter PM |
| Ref : British Journal of Pharmacology , 160 :1916 , 2010 |
| Abstract : |
| PubMedSearch : Hatfield_2010_Br.J.Pharmacol_160_1916 |
| PubMedID: 20649590 |
| Gene_locus related to this paper: human-CES1 |
| Title : Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis - Harada_2009_Bioorg.Med.Chem_17_149 |
| Author(s) : Harada T , Nakagawa Y , Wadkins RM , Potter PM , Wheelock CE |
| Ref : Bioorganic & Medicinal Chemistry , 17 :149 , 2009 |
| Abstract : |
| PubMedSearch : Harada_2009_Bioorg.Med.Chem_17_149 |
| PubMedID: 19062296 |
| Title : Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan\; CPT-11) toxicity - Hicks_2009_J.Med.Chem_52_3742 |
| Author(s) : Hicks LD , Hyatt JL , Stoddard S , Tsurkan L , Edwards CC , Wadkins RM , Potter PM |
| Ref : Journal of Medicinal Chemistry , 52 :3742 , 2009 |
| Abstract : |
| PubMedSearch : Hicks_2009_J.Med.Chem_52_3742 |
| PubMedID: 19534556 |
| Title : Modifications of human carboxylesterase for improved prodrug activation - Hatfield_2008_Expert.Opin.Drug.Metab.Toxicol_4_1153 |
| Author(s) : Hatfield JM , Wierdl M , Wadkins RM , Potter PM |
| Ref : Expert Opin Drug Metab Toxicol , 4 :1153 , 2008 |
| Abstract : |
| PubMedSearch : Hatfield_2008_Expert.Opin.Drug.Metab.Toxicol_4_1153 |
| PubMedID: 18721110 |
| Title : Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils - Hicks_2007_Bioorg.Med.Chem_15_3801 |
| Author(s) : Hicks LD , Hyatt JL , Moak T , Edwards CC , Tsurkan L , Wierdl M , Ferreira AM , Wadkins RM , Potter PM |
| Ref : Bioorganic & Medicinal Chemistry , 15 :3801 , 2007 |
| Abstract : |
| PubMedSearch : Hicks_2007_Bioorg.Med.Chem_15_3801 |
| PubMedID: 17399985 |
| Title : Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds - Wadkins_2007_Mol.Pharmacol_71_713 |
| Author(s) : Wadkins RM , Hyatt JL , Edwards CC , Tsurkan L , Redinbo MR , Wheelock CE , Jones PD , Hammock BD , Potter PM |
| Ref : Molecular Pharmacology , 71 :713 , 2007 |
| Abstract : |
| PubMedSearch : Wadkins_2007_Mol.Pharmacol_71_713 |
| PubMedID: 17167034 |
| Title : Selective inhibition of carboxylesterases by isatins, indole-2,3-diones - Hyatt_2007_J.Med.Chem_50_1876 |
| Author(s) : Hyatt JL , Moak T , Hatfield MJ , Tsurkan L , Edwards CC , Wierdl M , Danks MK , Wadkins RM , Potter PM |
| Ref : Journal of Medicinal Chemistry , 50 :1876 , 2007 |
| Abstract : |
| PubMedSearch : Hyatt_2007_J.Med.Chem_50_1876 |
| PubMedID: 17378546 |
| Title : Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1 - Hyatt_2007_J.Med.Chem_50_5727 |
| Author(s) : Hyatt JL , Wadkins RM , Tsurkan L , Hicks LD , Hatfield MJ , Edwards CC , Ross CR, 2nd , Cantalupo SA , Crundwell G , Danks MK , Guy RK , Potter PM |
| Ref : Journal of Medicinal Chemistry , 50 :5727 , 2007 |
| Abstract : |
| PubMedSearch : Hyatt_2007_J.Med.Chem_50_5727 |
| PubMedID: 17941623 |
| Title : Carboxylesterases--detoxifying enzymes and targets for drug therapy - Potter_2006_Curr.Med.Chem_13_1045 |
| Author(s) : Potter PM , Wadkins RM |
| Ref : Curr Med Chem , 13 :1045 , 2006 |
| Abstract : |
| PubMedSearch : Potter_2006_Curr.Med.Chem_13_1045 |
| PubMedID: 16611083 |
| Title : Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11 - Hyatt_2005_Chem.Biol.Interact_157-158_247 |
| Author(s) : Hyatt JL , Tsurkan L , Morton CL , Yoon KJ , Harel M , Brumshtein B , Silman I , Sussman JL , Wadkins RM , Potter PM |
| Ref : Chemico-Biological Interactions , 157-158 :247 , 2005 |
| Abstract : |
| PubMedSearch : Hyatt_2005_Chem.Biol.Interact_157-158_247 |
| PubMedID: 16257398 |
| Title : Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases - Wadkins_2005_J.Med.Chem_48_2906 |
| Author(s) : Wadkins RM , Hyatt JL , Wei X , Yoon KJ , Wierdl M , Edwards CC , Morton CL , Obenauer JC , Damodaran K , Beroza P , Danks MK , Potter PM |
| Ref : Journal of Medicinal Chemistry , 48 :2906 , 2005 |
| Abstract : |
| PubMedSearch : Wadkins_2005_J.Med.Chem_48_2906 |
| PubMedID: 15828829 |
| Title : Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety - Hyatt_2005_J.Med.Chem_48_5543 |
| Author(s) : Hyatt JL , Stacy V , Wadkins RM , Yoon KJ , Wierdl M , Edwards CC , Zeller M , Hunter AD , Danks MK , Crundwell G , Potter PM |
| Ref : Journal of Medicinal Chemistry , 48 :5543 , 2005 |
| Abstract : |
| PubMedSearch : Hyatt_2005_J.Med.Chem_48_5543 |
| PubMedID: 16107154 |
| Title : The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase - Harel_2005_Chem.Biol.Interact_157-158_153 |
| Author(s) : Harel M , Hyatt JL , Brumshtein B , Morton CL , Wadkins RM , Silman I , Sussman JL , Potter PM |
| Ref : Chemico-Biological Interactions , 157-158 :153 , 2005 |
| Abstract : |
| PubMedSearch : Harel_2005_Chem.Biol.Interact_157-158_153 |
| PubMedID: 16289500 |
| Gene_locus related to this paper: torca-ACHE |
| Title : The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action - Harel_2005_Mol.Pharmacol_67_1874 |
| Author(s) : Harel M , Hyatt JL , Brumshtein B , Morton CL , Yoon KJ , Wadkins RM , Silman I , Sussman JL , Potter PM |
| Ref : Molecular Pharmacology , 67 :1874 , 2005 |
| Abstract : |
| PubMedSearch : Harel_2005_Mol.Pharmacol_67_1874 |
| PubMedID: 15772291 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity - Wadkins_2004_Mol.Pharmacol_65_1336 |
| Author(s) : Wadkins RM , Hyatt JL , Yoon KJ , Morton CL , Lee RE , Damodaran K , Beroza P , Danks MK , Potter PM |
| Ref : Molecular Pharmacology , 65 :1336 , 2004 |
| Abstract : |
| PubMedSearch : Wadkins_2004_Mol.Pharmacol_65_1336 |
| PubMedID: 15155827 |
| Title : Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases - Wadkins_2001_Mol.Pharmacol_60_355 |
| Author(s) : Wadkins RM , Morton CL , Weeks JK , Oliver L , Wierdl M , Danks MK , Potter PM |
| Ref : Molecular Pharmacology , 60 :355 , 2001 |
| Abstract : |
| PubMedSearch : Wadkins_2001_Mol.Pharmacol_60_355 |
| PubMedID: 11455023 |
| Title : Water soluble 20(S)-glycinate esters of 10,11-methylenedioxycamptothecins are highly active against human breast cancer xenografts - Wadkins_1999_Cancer.Res_59_3424 |
| Author(s) : Wadkins RM , Potter PM , Vladu B , Marty J , Mangold G , Weitman S , Manikumar G , Wani MC , Wall ME , Von Hoff DD |
| Ref : Cancer Research , 59 :3424 , 1999 |
| Abstract : |
| PubMedSearch : Wadkins_1999_Cancer.Res_59_3424 |
| PubMedID: 10416605 |
| Title : The anticancer prodrug CPT-11 is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to SN-38 by butyrylcholinesterase - Morton_1999_Cancer.Res_59_1458 |
| Author(s) : Morton CL , Wadkins RM , Danks MK , Potter PM |
| Ref : Cancer Research , 59 :1458 , 1999 |
| Abstract : |
| PubMedSearch : Morton_1999_Cancer.Res_59_1458 |
| PubMedID: 10197614 |