Wierdl M

References (24)

Title : Tumour-selective targeting of drug metabolizing enzymes to treat metastatic cancer - Wierdl_2016_Br.J.Pharmacol_173_2811
Author(s) : Wierdl M , Tsurkan L , Hatfield MJ , Potter PM
Ref : British Journal of Pharmacology , 173 :2811 , 2016
Abstract :
PubMedSearch : Wierdl_2016_Br.J.Pharmacol_173_2811
PubMedID: 27423046

Title : Carboxylesterases: General detoxifying enzymes - Hatfield_2016_Chem.Biol.Interact_259_327
Author(s) : Hatfield MJ , Umans RA , Hyatt JL , Edwards CC , Wierdl M , Tsurkan L , Taylor MR , Potter PM
Ref : Chemico-Biological Interactions , 259 :327 , 2016
Abstract :
PubMedSearch : Hatfield_2016_Chem.Biol.Interact_259_327
PubMedID: 26892220

Title : Global and local molecular dynamics of a bacterial carboxylesterase provide insight into its catalytic mechanism - Yu_2012_J.Mol.Model_18_2869
Author(s) : Yu X , Sigler SC , Hossain D , Wierdl M , Gwaltney SR , Potter PM , Wadkins RM
Ref : J Mol Model , 18 :2869 , 2012
Abstract :
PubMedSearch : Yu_2012_J.Mol.Model_18_2869
PubMedID: 22127613

Title : Nerve agent hydrolysis activity designed into a human drug metabolism enzyme - Hemmert_2011_PLoS.One_6_e17441
Author(s) : Hemmert AC , Otto TC , Chica RA , Wierdl M , Edwards JS , Lewis SM , Edwards CC , Tsurkan L , Cadieux CL , Kasten SA , Cashman JR , Mayo SL , Potter PM , Cerasoli DM , Redinbo MR
Ref : PLoS ONE , 6 :e17441 , 2011
Abstract :
PubMedSearch : Hemmert_2011_PLoS.One_6_e17441
PubMedID: 21445272
Gene_locus related to this paper: human-CES1

Title : Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin - Hemmert_2010_Mol.Pharmacol_77_508
Author(s) : Hemmert AC , Otto TC , Wierdl M , Edwards CC , Fleming CD , MacDonald M , Cashman JR , Potter PM , Cerasoli DM , Redinbo MR
Ref : Molecular Pharmacology , 77 :508 , 2010
Abstract :
PubMedSearch : Hemmert_2010_Mol.Pharmacol_77_508
PubMedID: 20051531
Gene_locus related to this paper: human-CES1

Title : Modifications of human carboxylesterase for improved prodrug activation - Hatfield_2008_Expert.Opin.Drug.Metab.Toxicol_4_1153
Author(s) : Hatfield JM , Wierdl M , Wadkins RM , Potter PM
Ref : Expert Opin Drug Metab Toxicol , 4 :1153 , 2008
Abstract :
PubMedSearch : Hatfield_2008_Expert.Opin.Drug.Metab.Toxicol_4_1153
PubMedID: 18721110

Title : An improved human carboxylesterase for enzyme\/prodrug therapy with CPT-11 - Wierdl_2008_Cancer.Gene.Ther_15_183
Author(s) : Wierdl M , Tsurkan L , Hyatt JL , Edwards CC , Hatfield MJ , Morton CL , Houghton PJ , Danks MK , Redinbo MR , Potter PM
Ref : Cancer Gene Therapy , 15 :183 , 2008
Abstract :
PubMedSearch : Wierdl_2008_Cancer.Gene.Ther_15_183
PubMedID: 18188187

Title : Evaluation of the 'side door' in carboxylesterase-mediated catalysis and inhibition - Streit_2008_Biol.Chem_389_149
Author(s) : Streit TM , Borazjani A , Lentz SE , Wierdl M , Potter PM , Gwaltney SR , Ross MK
Ref : Biol Chem , 389 :149 , 2008
Abstract :
PubMedSearch : Streit_2008_Biol.Chem_389_149
PubMedID: 18163883

Title : Tumor-targeted enzyme\/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma - Danks_2007_Cancer.Res_67_22
Author(s) : Danks MK , Yoon KJ , Bush RA , Remack JS , Wierdl M , Tsurkan L , Kim SU , Garcia E , Metz MZ , Najbauer J , Potter PM , Aboody KS
Ref : Cancer Research , 67 :22 , 2007
Abstract :
PubMedSearch : Danks_2007_Cancer.Res_67_22
PubMedID: 17210679

Title : Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils - Hicks_2007_Bioorg.Med.Chem_15_3801
Author(s) : Hicks LD , Hyatt JL , Moak T , Edwards CC , Tsurkan L , Wierdl M , Ferreira AM , Wadkins RM , Potter PM
Ref : Bioorganic & Medicinal Chemistry , 15 :3801 , 2007
Abstract :
PubMedSearch : Hicks_2007_Bioorg.Med.Chem_15_3801
PubMedID: 17399985

Title : Selective inhibition of carboxylesterases by isatins, indole-2,3-diones - Hyatt_2007_J.Med.Chem_50_1876
Author(s) : Hyatt JL , Moak T , Hatfield MJ , Tsurkan L , Edwards CC , Wierdl M , Danks MK , Wadkins RM , Potter PM
Ref : Journal of Medicinal Chemistry , 50 :1876 , 2007
Abstract :
PubMedSearch : Hyatt_2007_J.Med.Chem_50_1876
PubMedID: 17378546

Title : Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity - Hyatt_2006_Mol.Cancer.Ther_5_2281
Author(s) : Hyatt JL , Tsurkan L , Wierdl M , Edwards CC , Danks MK , Potter PM
Ref : Mol Cancer Ther , 5 :2281 , 2006
Abstract :
PubMedSearch : Hyatt_2006_Mol.Cancer.Ther_5_2281
PubMedID: 16985062

Title : Update on gene therapy approaches for cancer - Wierdl_2005_Curr.Hematol.Rep_4_294
Author(s) : Wierdl M , Potter PM
Ref : Curr Hematol Rep , 4 :294 , 2005
Abstract :
PubMedSearch : Wierdl_2005_Curr.Hematol.Rep_4_294
PubMedID: 16009044

Title : Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases - Wadkins_2005_J.Med.Chem_48_2906
Author(s) : Wadkins RM , Hyatt JL , Wei X , Yoon KJ , Wierdl M , Edwards CC , Morton CL , Obenauer JC , Damodaran K , Beroza P , Danks MK , Potter PM
Ref : Journal of Medicinal Chemistry , 48 :2906 , 2005
Abstract :
PubMedSearch : Wadkins_2005_J.Med.Chem_48_2906
PubMedID: 15828829

Title : Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety - Hyatt_2005_J.Med.Chem_48_5543
Author(s) : Hyatt JL , Stacy V , Wadkins RM , Yoon KJ , Wierdl M , Edwards CC , Zeller M , Hunter AD , Danks MK , Crundwell G , Potter PM
Ref : Journal of Medicinal Chemistry , 48 :5543 , 2005
Abstract :
PubMedSearch : Hyatt_2005_J.Med.Chem_48_5543
PubMedID: 16107154

Title : Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model - Wierdl_2004_Biochemistry_43_1874
Author(s) : Wierdl M , Morton CL , Nguyen NK , Redinbo MR , Potter PM
Ref : Biochemistry , 43 :1874 , 2004
Abstract :
PubMedSearch : Wierdl_2004_Biochemistry_43_1874
PubMedID: 14967028

Title : p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) - Wierdl_2003_J.Pharmacol.Exp.Ther_304_699
Author(s) : Wierdl M , Morton CL , Harris LC , Danks MK , Schuetz JD , Potter PM
Ref : Journal of Pharmacology & Experimental Therapeutics , 304 :699 , 2003
Abstract :
PubMedSearch : Wierdl_2003_J.Pharmacol.Exp.Ther_304_699
PubMedID: 12538824

Title : Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance - Wierdl_2003_Mol.Pharmacol_64_279
Author(s) : Wierdl M , Wall A , Morton CL , Sampath J , Danks MK , Schuetz JD , Potter PM
Ref : Molecular Pharmacology , 64 :279 , 2003
Abstract :
PubMedSearch : Wierdl_2003_Mol.Pharmacol_64_279
PubMedID: 12869632

Title : Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase - Wierdl_2001_Cancer.Res_61_5078
Author(s) : Wierdl M , Morton CL , Weeks JK , Danks MK , Harris LC , Potter PM
Ref : Cancer Research , 61 :5078 , 2001
Abstract :
PubMedSearch : Wierdl_2001_Cancer.Res_61_5078
PubMedID: 11431344

Title : A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11 - Meck_2001_Cancer.Res_61_5083
Author(s) : Meck MM , Wierdl M , Wagner LM , Burger RA , Guichard SM , Krull EJ , Harris LC , Potter PM , Danks MK
Ref : Cancer Research , 61 :5083 , 2001
Abstract :
PubMedSearch : Meck_2001_Cancer.Res_61_5083
PubMedID: 11431345

Title : Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases - Wadkins_2001_Mol.Pharmacol_60_355
Author(s) : Wadkins RM , Morton CL , Weeks JK , Oliver L , Wierdl M , Danks MK , Potter PM
Ref : Molecular Pharmacology , 60 :355 , 2001
Abstract :
PubMedSearch : Wadkins_2001_Mol.Pharmacol_60_355
PubMedID: 11455023

Title : Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation - Wierdl_2000_Biochem.Pharmacol_59_773
Author(s) : Wierdl M , Morton CL , Danks MK , Potter PM
Ref : Biochemical Pharmacology , 59 :773 , 2000
Abstract :
PubMedSearch : Wierdl_2000_Biochem.Pharmacol_59_773
PubMedID: 10718335
Gene_locus related to this paper: horse-BCHE

Title : Activation of CPT-11 in mice: identification and analysis of a highly effective plasma esterase - Morton_2000_Cancer.Res_60_4206
Author(s) : Morton CL , Wierdl M , Oliver L , Ma MK , Danks MK , Stewart CF , Eiseman JL , Potter PM
Ref : Cancer Research , 60 :4206 , 2000
Abstract :
PubMedSearch : Morton_2000_Cancer.Res_60_4206
PubMedID: 10945631

Title : Cellular localization domains of a rabbit and a human carboxylesterase: influence on irinotecan (CPT-11) metabolism by the rabbit enzyme - Potter_1998_Cancer.Res_58_3627
Author(s) : Potter PM , Wolverton JS , Morton CL , Wierdl M , Danks MK
Ref : Cancer Research , 58 :3627 , 1998
Abstract :
PubMedSearch : Potter_1998_Cancer.Res_58_3627
PubMedID: 9721871