K727
General
Type : Oxime, Bispyridinium, Bisoxime, Pyridine-aldoxime
Chemical_Nomenclature : naphtylene-2,7-diyl-bis(2-hydroxy-iminomethylpyridinium) dibromide
Canonical SMILES : C1(=CC=[N+](C=C1)CC2=CC3=C(C=C2)C=CC(=C3)C[N+]4=CC=C(C=C4)C(=NO[H])[H])C(=NO[H])[H].[Br-].[Br-]
InChI : InChI=1S\/C24H20N4O2.2BrH\/c29-25-15-19-5-9-27(10-6-19)17-21-1-3-23-4-2-22(14-24(23)13-21)18-28-11-7-20(8-12-28)16-26-30\;\;\/h1-16H,17-18H2\;2*1H
InChIKey : DAKMWEHNZTZIIV-UHFFFAOYSA-N
Other name(s) : K-727
Target
Structure : No structure
Families : No family
References (2)
| Title : Reactivation potency of two novel oximes (K456 and K733) against paraoxon-inhibited acetyl and butyrylcholinesterase: In silico and in vitro models - Iqbal_2019_Chem.Biol.Interact_13ChEPon_310_108735 |
| Author(s) : Iqbal A , Malik S , Nurulain SM , Musilek K , Kuca K , Kalasz H , Fatmi MQ |
| Ref : Chemico-Biological Interactions , 310 :108735 , 2019 |
| Abstract : |
| PubMedSearch : Iqbal_2019_Chem.Biol.Interact_13ChEPon_310_108735 |
| PubMedID: 31276662 |
| Title : A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice - Kassa_2015_Toxicol.Mech.Methods_25_229 |
| Author(s) : Kassa J , Sepsova V , Matouskova L , Horova A , Musilek K |
| Ref : Toxicol Mech Methods , 25 :229 , 2015 |
| Abstract : |
| PubMedSearch : Kassa_2015_Toxicol.Mech.Methods_25_229 |
| PubMedID: 25894563 |