Phenyltetrahydroisoquinoline-Pyridinaldoxime-1b
General
Type : Oxime, Pyridine-aldoxime, Isoquinoline
Chemical_Nomenclature : 6-[4-(6,7-dimethoxy-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)butyl]-2-[(E)-hydroxyiminomethyl]pyridin-3-ol
Canonical SMILES : COC1=C(C=C2C(N(CCC2=C1)CCCCC3=NC(=C(C=C3)O)C=NO)C4=CC=CC=C4)OC
InChI : InChI=1S\/C27H31N3O4\/c1-33-25-16-20-13-15-30(14-7-6-10-21-11-12-24(31)23(29-21)18-28-32)27(19-8-4-3-5-9-19)22(20)17-26(25)34-2\/h3-5,8-9,11-12,16-18,27,31-32H,6-7,10,13-15H2,1-2H3\/b28-18+
InChIKey : OPEXRHHTTCQEDE-MTDXEUNCSA-N
Other name(s) : CHEMBL2181431
MW : 461.6
Formula : C27H31N3O4
CAS_number :
PubChem : 136015313
UniChem : OPEXRHHTTCQEDE-MTDXEUNCSA-N
Target
Structure : No structure
Families : No family
References (2)
| Title : Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase - Mercey_2012_J.Med.Chem_55_10791 |
| Author(s) : Mercey G , Renou J , Verdelet T , Kliachyna M , Baati R , Gillon E , Arboleas M , Loiodice M , Nachon F , Jean L , Renard PY |
| Ref : Journal of Medicinal Chemistry , 55 :10791 , 2012 |
| Abstract : |
| PubMedSearch : Mercey_2012_J.Med.Chem_55_10791 |
| PubMedID: 23148598 |
| Title : First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase - Mercey_2011_Chem.Commun.(Camb)_47_5295 |
| Author(s) : Mercey G , Verdelet T , Saint-Andre G , Gillon E , Wagner A , Baati R , Jean L , Nachon F , Renard PY |
| Ref : Chem Commun (Camb) , 47 :5295 , 2011 |
| Abstract : |
| PubMedSearch : Mercey_2011_Chem.Commun.(Camb)_47_5295 |
| PubMedID: 21451868 |