| Title : First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase - Mercey_2011_Chem.Commun.(Camb)_47_5295 |
| Author(s) : Mercey G , Verdelet T , Saint-Andre G , Gillon E , Wagner A , Baati R , Jean L , Nachon F , Renard PY |
| Ref : Chem Commun (Camb) , 47 :5295 , 2011 |
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Abstract :
Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE). Herein, we describe two first extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as compared to that of HI-6, obidoxime, TMB-4 and HLo-7. |
| PubMedSearch : Mercey_2011_Chem.Commun.(Camb)_47_5295 |
| PubMedID: 21451868 |
Mercey G, Verdelet T, Saint-Andre G, Gillon E, Wagner A, Baati R, Jean L, Nachon F, Renard PY (2011)
First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase
Chem Commun (Camb)
47 :5295
Mercey G, Verdelet T, Saint-Andre G, Gillon E, Wagner A, Baati R, Jean L, Nachon F, Renard PY (2011)
Chem Commun (Camb)
47 :5295