Jean L

General

Full name : Jean Ludovic

First name : Ludovic

Mail : UMR6014 COBRA\; Bio-organic Chemistry\; 1\; Rue Lucien Tesniere\; Mont Saint Aignan\; 76130

Zip Code :

City :

Country : France

Email : ludovic.jean@univ-rouen.fr

Phone : +33235522451

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References (30)

Title : Cholesterol Oxime Olesoxime Assessed as a Potential Ligand of Human Cholinesterases - Kolic_2024_Biomolecules_14_588
Author(s) : Kolic D , Sinko G , Jean L , Chioua M , Dias J , Marco-Contelles J , Kovarik, Z
Ref : Biomolecules , 14 :588 , 2024
PubMedID:

Title : A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning - Da Silva_2022_J.Med.Chem_65_4649
Author(s) : Da Silva O , Probst N , Landry C , Hanak AS , Warnault P , Coisne C , Calas AG , Gosselet F , Courageux C , Gastellier AJ , Trancart M , Baati R , Dehouck MP , Jean L , Nachon F , Renard PY , Dias J
Ref : Journal of Medicinal Chemistry , 65 :4649 , 2022
PubMedID: 35255209
Gene_locus related to this paper: human-ACHE

Title : Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP\/PS1 Mice - Viayna_2021_J.Med.Chem_64_812
Author(s) : Viayna E , Coquelle N , Cieslikiewicz-Bouet M , Cisternas P , Oliva CA , Sanchez-Lopez E , Ettcheto M , Bartolini M , De Simone A , Ricchini M , Rendina M , Pons M , Firuzi O , Perez B , Saso L , Andrisano V , Nachon F , Brazzolotto X , Garcia ML , Camins A , Silman I , Jean L , Inestrosa NC , Colletier JP , Renard PY , Munoz-Torrero D
Ref : Journal of Medicinal Chemistry , 64 :812 , 2021
PubMedID: 33356266
Gene_locus related to this paper: human-ACHE

Title : Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor - Cieslikiewicz-Bouet_2020_Biochem.Pharmacol__114010
Author(s) : Cieslikiewicz-Bouet M , Naldi M , Bartolini M , Perez B , Servent D , Jean L , Araoz R , Renard PY
Ref : Biochemical Pharmacology , :114010 , 2020
PubMedID: 32360492

Title : Pharmacokinetic evaluation of brain penetrating morpholine-3-hydroxy-2-pyridine oxime as an antidote for nerve agent poisoning - Zorbaz_2020_ACS.Chem.Neurosci__
Author(s) : Zorbaz T , Misetic P , Probst N , Zunec S , Zandona A , Mendas G , Micek V , Macek Hrvat N , Katalinic M , Braiki A , Jean L , Renard PY , Gabelica Markovic V , Kovarik Z
Ref : ACS Chem Neurosci , : , 2020
PubMedID: 32105443

Title : Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 - Oukoloff_2019_Eur.J.Med.Chem_168_58
Author(s) : Oukoloff K , Coquelle N , Bartolini M , Naldi M , Le Guevel R , Bach S , Josselin B , Ruchaud S , Catto M , Pisani L , Denora N , Iacobazzi RM , Silman I , Sussman JL , Buron F , Colletier JP , Jean L , Routier S , Renard PY
Ref : Eur Journal of Medicinal Chemistry , 168 :58 , 2019
PubMedID: 30798053
Gene_locus related to this paper: torca-ACHE

Title : In vivo localization of human acetylcholinesterase-derived species in a beta-sheet conformation at the core of senile plaques in Alzheimer's disease - Jean_2019_J.Biol.Chem_294_6253
Author(s) : Jean L , Brimijoin S , Vaux DJ
Ref : Journal of Biological Chemistry , 294 :6253 , 2019
PubMedID: 30787102

Title : Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection - Pashirova_2018_J.Control.Release_290_102
Author(s) : Pashirova TN , Braiki A , Zueva IV , Petrov KA , Babaev VM , Burilova EA , Samarkina DA , Rizvanov IK , Souto EB , Jean L , Renard PY , Masson P , Zakharova LY , Sinyashin OG
Ref : J Control Release , 290 :102 , 2018
PubMedID: 30308259

Title : Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis - Galdeano_2018_Molecules_23_
Author(s) : Galdeano C , Coquelle N , Cieslikiewicz-Bouet M , Bartolini M , Perez B , Clos MV , Silman I , Jean L , Colletier JP , Renard PY , Munoz-Torrero D
Ref : Molecules , 23 : , 2018
PubMedID: 29534488
Gene_locus related to this paper: torca-ACHE

Title : Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents - Santoni_2018_J.Med.Chem_61_7630
Author(s) : Santoni G , de Sousa J , De la Mora E , Dias J , Jean L , Sussman JL , Silman I , Renard PY , Brown RCD , Weik M , Baati R , Nachon F
Ref : Journal of Medicinal Chemistry , 61 :7630 , 2018
PubMedID: 30125110
Gene_locus related to this paper: torca-ACHE

Title : Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration - Zorbaz_2018_Chemistry_24_9675
Author(s) : Zorbaz T , Braiki A , Marakovic N , Renou J , De la Mora E , Macek Hrvat N , Katalinic M , Silman I , Sussman JL , Mercey G , Gomez C , Mougeot R , Perez B , Baati R , Nachon F , Weik M , Jean L , Kovarik Z , Renard PY
Ref : Chemistry , 24 :9675 , 2018
PubMedID: 29672968
Gene_locus related to this paper: torca-ACHE

Title : Probing the cholinergic system to understand neurodegenerative diseases -
Author(s) : Renard PY , Jean L
Ref : Future Med Chem , 9 :131 , 2017
PubMedID: 28097893

Title : An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice - Calas_2017_Chem.Biol.Interact_267_11
Author(s) : Calas AG , Dias J , Rousseau C , Arboleas M , Touvrey-Loiodice M , Mercey G , Jean L , Renard PY , Nachon F
Ref : Chemico-Biological Interactions , 267 :11 , 2017
PubMedID: 26972668

Title : A selective and sensitive near-infrared fluorescent probe for acetylcholinesterase imaging - Chao_2016_Chem.Commun.(Camb)_52_11599
Author(s) : Chao S , Krejci E , Bernard V , Leroy J , Jean L , Renard PY
Ref : Chem Commun (Camb) , 52 :11599 , 2016
PubMedID: 27604478

Title : Poster: Multi-target directed ligands: Electrophysiological characterization of an anticholinesterase inhibitor coupled to an agonist of alpha7 nicotinic acetylcholine receptor -
Author(s) : Araoz R , Bouet m , Bartolini M , Coquelle N , Colletier JP , Servent D , Molgo J , Jean L , Renard PY
Ref : Biochemical Pharmacology , 97 :621 , 2015
PubMedID:

Title : Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases - Renou_2014_Chem.Commun.(Camb)_50_3947
Author(s) : Renou J , Loiodice M , Arboleas M , Baati R , Jean L , Nachon F , Renard PY
Ref : Chem Commun (Camb) , 50 :3947 , 2014
PubMedID: 24599312

Title : Reaction site-driven regioselective synthesis of AChE inhibitors - Oueis_2014_Org.Biomol.Chem_12_156
Author(s) : Oueis E , Santoni G , Ronco C , Syzgantseva O , Tognetti V , Joubert L , Romieu A , Weik M , Jean L , Sabot C , Nachon F , Renard PY
Ref : Org Biomol Chem , 12 :156 , 2014
PubMedID: 24216754

Title : Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase - Kliachyna_2014_Eur.J.Med.Chem_78C_455
Author(s) : Kliachyna M , Santoni G , Nussbaum V , Renou J , Sanson B , Colletier JP , Arboleas M , Loiodice M , Weik M , Jean L , Renard PY , Nachon F , Baati R
Ref : Eur Journal of Medicinal Chemistry , 78C :455 , 2014
PubMedID: 24704618

Title : Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents - Renou_2013_Chem.Biol.Interact_203_81
Author(s) : Renou J , Mercey G , Verdelet T , Paunescu E , Gillon E , Arboleas M , Loiodice M , Kliachyna M , Baati R , Nachon F , Jean L , Renard PY
Ref : Chemico-Biological Interactions , 203 :81 , 2013
PubMedID: 23111374

Title : Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase - Nachon_2013_Biochem.J_453_393
Author(s) : Nachon F , Carletti E , Ronco C , Trovaslet M , Nicolet Y , Jean L , Renard PY
Ref : Biochemical Journal , 453 :393 , 2013
PubMedID: 23679855
Gene_locus related to this paper: human-ACHE , human-BCHE

Title : Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase - Mercey_2012_J.Med.Chem_55_10791
Author(s) : Mercey G , Renou J , Verdelet T , Kliachyna M , Baati R , Gillon E , Arboleas M , Loiodice M , Nachon F , Jean L , Renard PY
Ref : Journal of Medicinal Chemistry , 55 :10791 , 2012
PubMedID: 23148598

Title : Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography - Ronco_2012_ChemMedChem_7_400
Author(s) : Ronco C , Carletti E , Colletier JP , Weik M , Nachon F , Jean L , Renard PY
Ref : ChemMedChem , 7 :400 , 2012
PubMedID: 22052791
Gene_locus related to this paper: mouse-ACHE

Title : Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents - Mercey_2012_Acc.Chem.Res_45_756
Author(s) : Mercey G , Verdelet T , Renou J , Kliachyna M , Baati R , Nachon F , Jean L , Renard PY
Ref : Acc Chem Res , 45 :756 , 2012
PubMedID: 22360473

Title : Screening of new huprines--inhibitors of acetylcholinesterases by electrospray ionization ion trap mass spectrometry - Ziemianin_2012_J.Pharm.Biomed.Anal_70_1
Author(s) : Ziemianin A , Ronco C , Dole R , Jean L , Renard PY , Lange CM
Ref : J Pharm Biomed Anal , 70 :1 , 2012
PubMedID: 22677656

Title : Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure - Brazzolotto_2012_Febs.J_279_2905
Author(s) : Brazzolotto X , Wandhammer M , Ronco C , Trovaslet M , Jean L , Lockridge O , Renard PY , Nachon F
Ref : Febs J , 279 :2905 , 2012
PubMedID: 22726956
Gene_locus related to this paper: human-BCHE

Title : First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase - Mercey_2011_Chem.Commun.(Camb)_47_5295
Author(s) : Mercey G , Verdelet T , Saint-Andre G , Gillon E , Wagner A , Baati R , Jean L , Nachon F , Renard PY
Ref : Chem Commun (Camb) , 47 :5295 , 2011
PubMedID: 21451868

Title : New huprine derivatives functionalized at position 9 as highly potent acetylcholinesterase inhibitors - Ronco_2011_ChemMedChem_6_876
Author(s) : Ronco C , Foucault R , Gillon E , Bohn P , Nachon F , Jean L , Renard PY
Ref : ChemMedChem , 6 :876 , 2011
PubMedID: 21344648

Title : Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors - Ronco_2009_Bioorg.Med.Chem_17_4523
Author(s) : Ronco C , Sorin G , Nachon F , Foucault R , Jean L , Romieu A , Renard PY
Ref : Bioorganic & Medicinal Chemistry , 17 :4523 , 2009
PubMedID: 19473849

Title : Structural elements regulating amyloidogenesis: a cholinesterase model system - Jean_2008_PLoS.One_3_e1834
Author(s) : Jean L , Lee CF , Shaw M , Vaux DJ
Ref : PLoS ONE , 3 :e1834 , 2008
PubMedID: 18350169

Title : Heterologous amyloid seeding: revisiting the role of acetylcholinesterase in Alzheimer's disease - Jean_2007_PLoS.One_2_e652
Author(s) : Jean L , Thomas B , Tahiri-Alaoui A , Shaw M , Vaux DJ
Ref : PLoS ONE , 2 :e652 , 2007
PubMedID: 17653279