Name : Torpedo acetylcholinesterase complexed with transition state analog with m-(N,N,N-trimethyammonio)trifluoroacetophenone (TMTFA, NAF)

Revelation date : 03-Apr-1996

Family : ACHE

Gene_locus : torca-ACHE

PDB file : ESTHER: header of PDB entry RCSB: Full entry

TMTFA is an equilibrium mixture of the free ketone and ketone hydrate NAF in aqueous solution, with a hydration equilibrium constant of 60 000

Ligand : 02

References (2)

Title : A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase - Silman_1999_Chem.Biol.Interact_119-120_43
Author(s) : Silman I , Millard CB , Ordentlich A , Greenblatt HM , Harel M , Barak D , Shafferman A , Sussman JL
Ref : Chemico-Biological Interactions , 119-120 :43 , 1999
PubMedID: 10421437
Gene_locus related to this paper: torca-ACHE

Title : The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase. -
Author(s) : Harel M , Quinn DM , Nair HK , Silman I , Sussman JL
Ref : Journal of the American Chemical Society , 118 :2340 , 1996
Gene_locus related to this paper: torca-ACHE

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server


PDB-Sum : 1AMN Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 1AMN Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 1AMN Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 1AMN 3D, interactive encyclopedia of proteins - PROTEOPEDIA server