Name : Crystal structure of Dipeptidyl Peptidase IV in complex with a pyrimidinedione inhibitor 1

Revelation date : 16-Feb-2010

Family : DPP4N_Peptidase_S9

Gene_locus : human-DPP4

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Zhang, Zhiyuan, Wallace, Michael B., Feng, Jun, Stafford, Jeffrey A., Kaldor, Stephen W., Lihong, Shi, Skene, Robert J., Aertgeerts, Kathleen, Lee, Bumsup, Jennings, Andy, Xu, Rongda, Kassel, Daniel, Webb, David R., Gwaltney, Stephen L.

Ligand : Inhibitor Pyrimidinone-inhibitor1 Ligand in structure: Ligplot

References (1)

Title : Design and synthesis of pyrimidinone and pyrimidinedione inhibitors of dipeptidyl peptidase IV - Zhang_2011_J.Med.Chem_54_510
Author(s) : Zhang Z , Wallace MB , Feng J , Stafford JA , Skene RJ , Shi L , Lee B , Aertgeerts K , Jennings A , Xu R , Kassel DB , Kaldor SW , Navre M , Webb DR , Gwaltney SL
Ref : Journal of Medicinal Chemistry , 54 :510 , 2011
Abstract :
PubMedSearch : Zhang_2011_J.Med.Chem_54_510
PubMedID: 21186796
Gene_locus related to this paper: human-DPP4

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server


PDB-Sum : 3G0C Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 3G0C Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 3G0C Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 3G0C 3D, interactive encyclopedia of proteins - PROTEOPEDIA server