4LKO

Name : Crystal structure of human DPP-IV in complex with BMS-744891

Revelation date : 04-Sep-2013

Family : DPP4N_Peptidase_S9

Gene_locus : human-DPP4

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Klei, H.E.

Ligand :

References (1)

Title : Optimization of Activity, Selectivity, and Liability Profiles in 5-Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate (Sa)-2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]py ridin-6(7H)-yl)-N,N-dimethylacetamide (BMS-767778) - Devasthale_2013_J.Med.Chem_56_7343
Author(s) : Devasthale P , Wang Y , Wang W , Fevig J , Feng J , Wang A , Harrity T , Egan D , Morgan N , Cap M , Fura A , Klei HE , Kish K , Weigelt C , Sun L , Levesque P , Moulin F , Li YX , Zahler R , Kirby MS , Hamann LG
Ref : Journal of Medicinal Chemistry , 56 :7343 , 2013
PubMedID: 23964740
Gene_locus related to this paper: human-DPP4

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases

PDB-Sum : 4LKO Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 4LKO Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 4LKO Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 4LKO 3D, interactive encyclopedia of proteins - PROTEOPEDIA server