6YXI

Name : Structure of human Notum in complex with a 1-(3-Chlorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylic acid inhibitor

Revelation date : 19-Aug-2020

Family : Pectinacetylesterase-Notum

Gene_locus : human-NOTUM

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Vecchia, L., Jones, E.Y., Ruza, R.R., Hillier, J., Zhao, Y.

Ligand :

References (1)

Title : Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity - Mahy_2020_J.Med.Chem_63_9464
Author(s) : Mahy W , Patel M , Steadman D , Woodward HL , Atkinson BN , Svensson F , Willis NJ , Flint A , Papatheodorou D , Zhao Y , Vecchia L , Ruza RR , Hillier J , Frew S , Monaghan A , Costa A , Bictash M , Walter MW , Jones EY , Fish PV
Ref : Journal of Medicinal Chemistry , 63 :9464 , 2020
PubMedID: 32787107
Gene_locus related to this paper: human-NOTUM

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases

PDB-Sum : 6YXI Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 6YXI Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 6YXI Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 6YXI 3D, interactive encyclopedia of proteins - PROTEOPEDIA server