8HAY

Name : Bacteroides thetaiotaomicron bacterial d4 bound btDPP4

Revelation date : 14-Jun-2023

Family : DPP4N_Peptidase_S9

Gene_locus : bactn-BT4193

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Hang, J., Jiang, C., Wang, K., Zhang, Z., Guo, F., Liu, J., Wang, G., Lei, X., Gonzalez, F., Qiao, J. Dipeptidyl peptidase 4 (DPP4) is expressed by specific bacterial taxa of the microbiota. Microbial DPP4 is able to decrease the active glucagon like peptide-1 (GLP-1) and disrupt glucose metabolism in mice with a leaky gut. Sitagliptin, has little effect on microbial DPP4. daurisoline-d4 (Dau-d4) is a selective microbial DPP4 inhibitor that improves glucose tolerance in diabetic mice.

Ligand :

References (1)

Title : Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target - Wang_2023_Science_381_eadd5787
Author(s) : Wang K , Zhang Z , Hang J , Liu J , Guo F , Ding Y , Li M , Nie Q , Lin J , Zhuo Y , Sun L , Luo X , Zhong Q , Ye C , Yun C , Zhang Y , Wang J , Bao R , Pang Y , Wang G , Gonzalez FJ , Lei X , Qiao J , Jiang C
Ref : Science , 381 :eadd5787 , 2023
Abstract : Wang_2023_Science_381_eadd5787
ESTHER : Wang_2023_Science_381_eadd5787
PubMedSearch : Wang_2023_Science_381_eadd5787
PubMedID: 37535747
Gene_locus related to this paper: bactn-BT4193

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

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