bactn-BT4193
Bacteroides thetaiotaomicron, Bacteroides caccae, Bacteroides ovatus, Bacteroides sp.,Bacteroides xylanisolvens, dipeptidyl peptidase IV
Comment
The sequence is the one of the structure. Other strains: Bacteroides thetaiotaomicron (strain ATCC 29148 \/ DSM 2079 \/ NCTC 10582 \/ E50 \/ VPI-5482) Bacteroides caccae (ATCC 43185), Bacteroides ovatus (ATCC 8483\; SD CMC 3f\; SD CC 2a), Bacteroides sp. (D1\; 2_2_4\; 1_1_6\; 2_1_22\; 1_1_14\; D22\; 3_1_23\; D2),Bacteroides xylanisolvens (SD CC 1b\; XB1A). Dipeptidyl peptidase 4 (DPP4) is expressed by specific bacterial taxa of the microbiota. Microbial DPP4 is able to decrease the active glucagon like peptide-1 (GLP-1) and disrupt glucose metabolism in mice with a leaky gut. Sitagliptin, has little effect on microbial DPP4. daurisoline-d4 (Dau-d4) is a selective microbial DPP4 inhibitor that improves glucose tolerance in diabetic mice.
Relationship
Family : DPP4N_Peptidase_S9
Block : X
Position in NCBI Life Tree : Bacteroides thetaiotaomicron
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > FCB group N E > Bacteroidetes\/Chlorobi group N E > Bacteroidetes N E > Bacteroidia N E > Bacteroidales N E > Bacteroidaceae N E > Bacteroides N E > Bacteroides thetaiotaomicron N EMolecular evidence
Database
Sequence
Peptide
MRKVSLALLL CLLCLAGMAQ GQKALDLKDI TSGRFRPENI QGVIPMPDGE HYTQMSADGT QIIKYSFRTG EKVEVIFDVN QARECDFKNF DSYQFSPDGD KLLIATRTTP IYRHSYTAVH YIYPLKRNDK GVTTNNIIER LSDGGPQQVP VFSPDGTMIA FVRDNNIFLV KLLYGNSESQ VTEDGKQNSV LNGIPDWVYE EEFGFNRALE FSADNTMIAF IRFDESEVPS YSFPMFAGEA PQITPLKDYP GEYTYKYPKA GYPNSKVEVR TYDIKSHVTR TMKLPIDADG YIPRIRFTKD ASKLAVMTLN RHQDRFDLYF ADPRSTLCKL VLRDESPYYI KENVFDNIKF YPETFSLLSE RDGFSHLYWY SMGGNLIKKV TNGKYEVKDF LGYDEADGSF YYTSNEESPL RKAVYKIDKK GKKLKLSQRE GTNTPLFSQS MKYYMNKFSN LDTPMLVTLN DNTGKTLKTL INNDQLKQTL SGYAIPQKEF FTFQTTDGVT LNGWMMKPAN FSTSKKYPVL MYQYSGPGSQ QVLDTWGISW ETYMASLGYI VVCVDGRGTG GRGEAFEKCT YLKIGVKEAK DQVETALYLG KQPYVDKDRI GIWGWSYGGY MTLMSMSEGT PVFKAGVAVA APTDWRFYDT IYTERFMRTP KENAEGYKES SAFTRADKLH GNLLLVHGMA DDNVHFQNCA EYAEHLVQLG KQFDMQVYTN RNHGIYGGNT RQHLYTRLTN FFLNNL
References (2)
| Title : Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target - Wang_2023_Science_381_eadd5787 |
| Author(s) : Wang K , Zhang Z , Hang J , Liu J , Guo F , Ding Y , Li M , Nie Q , Lin J , Zhuo Y , Sun L , Luo X , Zhong Q , Ye C , Yun C , Zhang Y , Wang J , Bao R , Pang Y , Wang G , Gonzalez FJ , Lei X , Qiao J , Jiang C |
| Ref : Science , 381 :eadd5787 , 2023 |
| Abstract : |
| PubMedSearch : Wang_2023_Science_381_eadd5787 |
| PubMedID: 37535747 |
| Gene_locus related to this paper: bactn-BT4193 |
| Title : A genomic view of the human-Bacteroides thetaiotaomicron symbiosis - Xu_2003_Science_299_2074 |
| Author(s) : Xu J , Bjursell MK , Himrod J , Deng S , Carmichael LK , Chiang HC , Hooper LV , Gordon JI |
| Ref : Science , 299 :2074 , 2003 |
| Abstract : |
| PubMedSearch : Xu_2003_Science_299_2074 |
| PubMedID: 12663928 |
| Gene_locus related to this paper: bacth-BT1008 , bacth-BT1087 , bacth-BT1121 , bacth-BT1192 , bacth-BT1400 , bacth-BT1838 , bacth-BT2436 , bacth-BT3100 , bacth-BT4214 , bactn-BT0152 , bactn-BT0587 , bactn-BT1114 , bactn-BT1261 , bactn-BT2379 , bactn-BT2525 , bactn-BT3084 , bactn-BT3112 , bactn-BT3254 , bactn-BT3286 , bactn-BT3608 , bactn-BT4077 , bactn-BT4193 , bactn-q8a7t0 |