O-Methyl-Dauracine
Dipeptidyl peptidase 4 (DPP4) is expressed by specific bacterial taxa of the microbiota. Microbial DPP4 is able to decrease the active glucagon like peptide-1 (GLP-1) and disrupt glucose metabolism in mice with a leaky gut. Sitagliptin, has little effect on microbial DPP4. daurisoline-d4 (Dau-d4) is a selective microbial DPP4 inhibitor that improves glucose tolerance in diabetic mice. (dopamine D2 receptor dopamine transporter-mediated dopamine uptake)
General
Type : Alkaloid, Natural, Quinoline
Chemical_Nomenclature : (1~{R})-1-[[4-[5-[[(1~{R})-6,7-dimethoxy-2-methyl-3,4-dihydro-1~{H}-isoquinolin-1-yl]methyl]-2-methoxy-phenoxy]phenyl]methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1~{H}-isoquinoline
Canonical SMILES : CN1CCc2cc(c(cc2[C@H]1Cc3ccc(cc3)Oc4cc(ccc4OC)C[C@@H]5c6cc(c(cc6CCN5C)OC)OC)OC)OC
InChI : InChI=1S\/C39H46N2O6\/c1-40-16-14-27-21-35(43-4)37(45-6)23-30(27)32(40)18-25-8-11-29(12-9-25)47-39-20-26(10-13-34(39)42-3)19-33-31-24-38(46-7)36(44-5)22-28(31)15-17-41(33)2\/h8-13,20-24,32-33H,14-19H2,1-7H3\/t32-,33-\/m1\/s1
InChIKey : UHYCXSGUNAWVBW-CZNDPXEESA-N
Other name(s) : KYL || daurisoline-d4 || Dau-d4 || O-Methyldauricine || O,O-Dimethylcuspidaline || O,O-Dimethyldauricinoline || CHEMBL501861
MW : 638.79
Formula : C39H46N2O6
CAS_number : 2202-17-7
PubChem : 200521
UniChem : UHYCXSGUNAWVBW-CZNDPXEESA-N
Target
Families : O-Methyl-Dauracine ligand of proteins in family
DPP4N_Peptidase_S9
Structure :
8HAY
Protein :
bactn-BT4193
References (3)
| Title : Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target - Wang_2023_Science_381_eadd5787 |
| Author(s) : Wang K , Zhang Z , Hang J , Liu J , Guo F , Ding Y , Li M , Nie Q , Lin J , Zhuo Y , Sun L , Luo X , Zhong Q , Ye C , Yun C , Zhang Y , Wang J , Bao R , Pang Y , Wang G , Gonzalez FJ , Lei X , Qiao J , Jiang C |
| Ref : Science , 381 :eadd5787 , 2023 |
| Abstract : |
| PubMedSearch : Wang_2023_Science_381_eadd5787 |
| PubMedID: 37535747 |
| Gene_locus related to this paper: bactn-BT4193 |
| Title : Microbial gatekeepers: unraveling the role of the gut microbiota enzyme DPP4 in diabetes management - Liao_2023_Trends.Biochem.Sci__ |
| Author(s) : Liao L , Lin F , Gao J |
| Ref : Trends in Biochemical Sciences , : , 2023 |
| Abstract : |
| PubMedSearch : Liao_2023_Trends.Biochem.Sci__ |
| PubMedID: 37770288 |
| Title : Effects of various isoquinoline alkaloids on in vitro 3H-dopamine uptake by rat striatal synaptosomes - Protais_1995_J.Nat.Prod_58_1475 |
| Author(s) : Protais P , Arbaoui J , Bakkali EH , Bermejo A , Cortes D |
| Ref : Journal of Natural Products , 58 :1475 , 1995 |
| Abstract : |
| PubMedSearch : Protais_1995_J.Nat.Prod_58_1475 |
| PubMedID: 8676127 |