8S75
Name : Soluble epoxide hydrolase in complex with PROTAC FL412
Revelation date : 12-Mar-2025
Family : Epoxide_hydrolase
Gene_locus : human-EPHX2
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Kumar, A.,Schoenfeld, J.,Hiesinger, K.,Lillich, F.,Proschak, E.,Knapp, S.,Structural Genomics Consortium (SGC)
Ligand : Inhibitor PROTAC-FL412 Ligand in structure: Ligplot
References (3)
| Title : Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase - Schonfeld_2025_J.Med.Chem__ |
| Author(s) : Schonfeld J , Brunst S , Ciomirtan L , Willmer L , Chromik MA , Kumar A , Froemel T , Liebisch N , Hackspacher A , Ehrler JHM , Wintermeier L , Hesse C , Fiedler J , Heering J , Freitag H , Zardo P , Fieguth HG , Bruggerhoff A , Jakob J , Haupl B , Weizel L , Kaiser A , Schubert-Zsilavecz M , Oellerich T , Fleming I , Schebb NH , Furst R , Kannt A , Knapp S , Proschak E , Hiesinger K |
| Ref : Journal of Medicinal Chemistry , : , 2025 |
| Abstract : |
| PubMedSearch : Schonfeld_2025_J.Med.Chem__ |
| PubMedID: 40532036 |
| Title : Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase - Schonfeld_2025_J.Med.Chem__ |
| Author(s) : Schonfeld J , Brunst S , Ciomirtan L , Willmer L , Chromik MA , Kumar A , Froemel T , Liebisch N , Hackspacher A , Ehrler JHM , Wintermeier L , Hesse C , Fiedler J , Heering J , Freitag H , Zardo P , Fieguth HG , Bruggerhoff A , Jakob J , Haupl B , Weizel L , Kaiser A , Schubert-Zsilavecz M , Oellerich T , Fleming I , Schebb NH , Furst R , Kannt A , Knapp S , Proschak E , Hiesinger K |
| Ref : Journal of Medicinal Chemistry , : , 2025 |
| Abstract : |
| PubMedSearch : Schonfeld_2025_J.Med.Chem__ |
| PubMedID: 40532036 |
| Title : Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase - Schonfeld_2025_J.Med.Chem__ |
| Author(s) : Schonfeld J , Brunst S , Ciomirtan L , Willmer L , Chromik MA , Kumar A , Froemel T , Liebisch N , Hackspacher A , Ehrler JHM , Wintermeier L , Hesse C , Fiedler J , Heering J , Freitag H , Zardo P , Fieguth HG , Bruggerhoff A , Jakob J , Haupl B , Weizel L , Kaiser A , Schubert-Zsilavecz M , Oellerich T , Fleming I , Schebb NH , Furst R , Kannt A , Knapp S , Proschak E , Hiesinger K |
| Ref : Journal of Medicinal Chemistry , : , 2025 |
| Abstract : |
| PubMedSearch : Schonfeld_2025_J.Med.Chem__ |
| PubMedID: 40532036 |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
Databases
PDB-Sum : 8S75 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP : 8S75 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP : 8S75 Structural Classification Of Protein - SCOP server
PROTEOPEDIA : 8S75 3D, interactive encyclopedia of proteins - PROTEOPEDIA server