9GON
Name : Crystal structure of DPP9 in complex with sulphostin (Azanyl-oxidanylidene-(sulfoamino)phosphanium-A1INF)
Revelation date : 16-Jul-2025
Family : DPP4N_Peptidase_S9
Gene_locus : human-DPP9
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Sewald, L.,Tabak, W.W.A.,Fehr, L.,Zolg, S.,Najdzion, M.,Verhoef, C.J.A.,Podlesainski, D.,Geiss-Friedlander, R.,Lammens, A.,Kaschani, F.,Hellerschmied, D.,Huber, R.,Kaiser, M. || Azanyl-oxidanylidene-(sulfoamino)phosphanium-A1INF Adduct covalently linked to active serine
Ligand : Inhibitor Sulphostin, Azanyl-oxidanylidene-(sulfoamino)phosphanium-A1INF Ligand in structure: Ligplot
References (1)
| Title : Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitors - Sewald_2025_Nat.Commun_16_3208 |
| Author(s) : Sewald L , Tabak WWA , Fehr L , Zolg S , Najdzion M , Verhoef CJA , Podlesainski D , Geiss-Friedlander R , Lammens A , Kaschani F , Hellerschmied D , Huber R , Kaiser M |
| Ref : Nat Commun , 16 :3208 , 2025 |
| Abstract : |
| PubMedSearch : Sewald_2025_Nat.Commun_16_3208 |
| PubMedID: 40180908 |
| Gene_locus related to this paper: human-DPP4 , human-DPP8 , human-DPP9 |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
Databases
PDB-Sum : 9GON Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP : 9GON Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP : 9GON Structural Classification Of Protein - SCOP server
PROTEOPEDIA : 9GON 3D, interactive encyclopedia of proteins - PROTEOPEDIA server