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Structure Report for: 5E4T

Name|Acetycholinesterase Methylen Blue with PEG (replaces 2W9I)
Revelation date|30-Mar-2016
Family|ACHE: there are 538 genes in this family, 315 structure(s)
Gene_locus|torca-ACHE
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Dym, O. Paz, A., Xu, Y., Greenblatt, H.M., Roth, E., Ashani, Y., Shnyrov, V., Sussman, J.L., Silman, I., Weiner, L.
Ligand|Inhibitor: Methylene-blue Ligand in structure: Ligplot Inhibitor: Diethylene-glycol Ligand in structure: Ligplot Inhibitor: Triethylene-glycol Ligand in structure: Ligplot


Reference

    Title: The Impact of Crystallization Conditions on Structure-Based Drug Design: A Case Study on the Methylene Blue/Acetylcholinesterase Complex
    Dym O, Song W, Felder CE, Roth E, Shnyrov V, Ashani Y, Xu Y, Joosten RP, Weiner L and Silman I <1 more author(s)>
    Ref: Protein Science, 25:1096, 2016 : PubMed

            

    Title: Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase
    Paz A, Roth E, Ashani Y, Xu Y, Shnyrov VL, Sussman JL, Silman I, Weiner L
    Ref: Protein Science, 21:1138, 2012 : PubMed

            



Representative scheme of ACHE structure and an image from PDBsum server



Databases

PDB-Sum5E4T Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP5E4T Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP5E4T Structural Classification Of Protein - SCOP server
PROTEOPEDIA5e4t 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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