Ashani Y

General

Full name : Ashani Yacov

First name : Yacov

Mail : The Weizmann Institute of Science\;, Structural Biology and Department of Neurobiology\; Herzl st. P.O.Box 26, Rehovot, 76100\; Rehovot 75100

Zip Code :

City :

Country : Israel

Email : yaacov.ashani@weizmann.ac.il

Phone : +972-8-9342128

Fax :

Website :

Directory :

References (96)

Title : Utilization of diverse organophosphorus pollutants by marine bacteria - Despotovic_2022_Proc.Natl.Acad.Sci.U.S.A_119_e2203604119
Author(s) : Despotovic D , Aharon E , Trofimyuk O , Dubovetskyi A , Cherukuri KP , Ashani Y , Eliason O , Sperfeld M , Leader H , Castelli A , Fumagalli L , Savidor A , Levin Y , Longo LM , Segev E , Tawfik DS
Ref : Proc Natl Acad Sci U S A , 119 :e2203604119 , 2022
Abstract :
PubMedSearch : Despotovic_2022_Proc.Natl.Acad.Sci.U.S.A_119_e2203604119
PubMedID: 35917352

Title : Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif - Silman_2021_Protein.Sci_30_966
Author(s) : Silman I , Shnyrov VL , Ashani Y , Roth E , Nicolas A , Sussman JL , Weiner L
Ref : Protein Science , 30 :966 , 2021
Abstract :
PubMedSearch : Silman_2021_Protein.Sci_30_966
PubMedID: 33686648
Gene_locus related to this paper: torca-ACHE

Title : Widespread Utilization of Diverse Organophosphate Pollutants by Marine Bacteria - Despotovic_2021_Biorxiv__
Author(s) : Despotovic D , Aharon E , Trofimyuk O , Dubovetskyi A , Cherukuri KP , Ashani Y , Leader H , Castelli A , Fumagalli A , Savidor A , Levin Y , Longo LM , Segev E , Tawfik DS
Ref : Biorxiv , : , 2020
Abstract :
PubMedSearch : Despotovic_2021_Biorxiv__
PubMedID:

Title : A mixture of three engineered phosphotriesterases enables rapid detoxification of the entire spectrum of known threat nerve agents - Despotovic_2019_Protein.Eng.Des.Sel_32_169
Author(s) : Despotovic D , Aharon E , Dubovetskyi A , Leader H , Ashani Y , Tawfik DS
Ref : Protein Engineering Des Sel , 32 :169 , 2019
Abstract :
PubMedSearch : Despotovic_2019_Protein.Eng.Des.Sel_32_169
PubMedID: 31612205

Title : Catalytic bioscavengers as countermeasures against organophosphate nerve agents - Goldsmith_2018_Chem.Biol.Interact_292_50
Author(s) : Goldsmith M , Ashani Y
Ref : Chemico-Biological Interactions , 292 :50 , 2018
Abstract :
PubMedSearch : Goldsmith_2018_Chem.Biol.Interact_292_50
PubMedID: 29990481

Title : Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability - Goldenzweig_2016_Mol.Cell_63_337
Author(s) : Goldenzweig A , Goldsmith M , Hill SE , Gertman O , Laurino P , Ashani Y , Dym O , Unger T , Albeck S , Prilusky J , Lieberman RL , Aharoni A , Silman I , Sussman JL , Tawfik DS , Fleishman SJ
Ref : Mol Cell , 63 :337 , 2016
Abstract :
PubMedSearch : Goldenzweig_2016_Mol.Cell_63_337
PubMedID: 27425410
Gene_locus related to this paper: human-ACHE

Title : Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection - Wille_2016_Toxicol.Lett_258_198
Author(s) : Wille T , Neumaier K , Koller M , Ehinger C , Aggarwal N , Ashani Y , Goldsmith M , Sussman JL , Tawfik DS , Thiermann H , Worek F
Ref : Toxicol Lett , 258 :198 , 2016
Abstract :
PubMedSearch : Wille_2016_Toxicol.Lett_258_198
PubMedID: 27397758

Title : The Impact of Crystallization Conditions on Structure-Based Drug Design: A Case Study on the Methylene Blue\/Acetylcholinesterase Complex - Dym_2016_Protein.Sci_25_1096
Author(s) : Dym O , Song W , Felder CE , Roth E , Shnyrov V , Ashani Y , Xu Y , Joosten RP , Weiner L , Sussman JL , Silman I
Ref : Protein Science , 25 :1096 , 2016
Abstract :
PubMedSearch : Dym_2016_Protein.Sci_25_1096
PubMedID: 26990888
Gene_locus related to this paper: torca-ACHE

Title : In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications - Ashani_2016_Chem.Biol.Interact_259_252
Author(s) : Ashani Y , Leader H , Aggarwal N , Silman I , Worek F , Sussman JL , Goldsmith M
Ref : Chemico-Biological Interactions , 259 :252 , 2016
Abstract :
PubMedSearch : Ashani_2016_Chem.Biol.Interact_259_252
PubMedID: 27163850

Title : Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro - Goldsmith_2016_Arch.Toxicol_90_2711
Author(s) : Goldsmith M , Eckstein S , Ashani Y , Greisen P, Jr. , Leader H , Sussman JL , Aggarwal N , Ovchinnikov S , Tawfik DS , Baker D , Thiermann H , Worek F
Ref : Archives of Toxicology , 90 :2711 , 2016
Abstract :
PubMedSearch : Goldsmith_2016_Arch.Toxicol_90_2711
PubMedID: 26612364

Title : A new post-intoxication treatment of paraoxon and parathion poisonings using an evolved PON1 variant and recombinant GOT1 - Goldsmith_2016_Chem.Biol.Interact_259_242
Author(s) : Goldsmith M , Ashani Y , Margalit R , Nyska A , Mirelman D , Tawfik DS
Ref : Chemico-Biological Interactions , 259 :242 , 2016
Abstract :
PubMedSearch : Goldsmith_2016_Chem.Biol.Interact_259_242
PubMedID: 27256520

Title : Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro - Worek_2014_Arch.Toxicol_88_1257
Author(s) : Worek F , Seeger T , Goldsmith M , Ashani Y , Leader H , Sussman JL , Tawfik DS , Thiermann H , Wille T
Ref : Archives of Toxicology , 88 :1257 , 2014
Abstract :
PubMedSearch : Worek_2014_Arch.Toxicol_88_1257
PubMedID: 24477626

Title : Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: A proof-of-concept study - Worek_2014_Toxicol.Lett_231_45
Author(s) : Worek F , Seeger T , Reiter G , Goldsmith M , Ashani Y , Leader H , Sussman JL , Aggarwal N , Thiermann H , Tawfik DS
Ref : Toxicol Lett , 231 :45 , 2014
Abstract :
PubMedSearch : Worek_2014_Toxicol.Lett_231_45
PubMedID: 25195526

Title : Engineering v-type nerve agents detoxifying enzymes using computationally focused libraries - Cherny_2013_ACS.Chem.Biol_8_2394
Author(s) : Cherny I , Greisen P, Jr. , Ashani Y , Khare SD , Oberdorfer G , Leader H , Baker D , Tawfik DS
Ref : ACS Chemical Biology , 8 :2394 , 2013
Abstract :
PubMedSearch : Cherny_2013_ACS.Chem.Biol_8_2394
PubMedID: 24041203

Title : The specific interaction of the photosensitizer methylene blue with acetylcholinesterase provides a model system for studying the molecular consequences of photodynamic therapy - Silman_2013_Chem.Biol.Interact_203_63
Author(s) : Silman I , Roth E , Paz A , Triquigneaux MM , Ehrenshaft M , Xu Y , Shnyrov VL , Sussman JL , Deterding LJ , Ashani Y , Mason RP , Weiner L
Ref : Chemico-Biological Interactions , 203 :63 , 2013
Abstract :
PubMedSearch : Silman_2013_Chem.Biol.Interact_203_63
PubMedID: 23159732

Title : Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification - Goldsmith_2012_Chem.Biol_19_456
Author(s) : Goldsmith M , Ashani Y , Simo Y , Ben-David M , Leader H , Silman I , Sussman JL , Tawfik DS
Ref : Chemical Biology , 19 :456 , 2012
Abstract :
PubMedSearch : Goldsmith_2012_Chem.Biol_19_456
PubMedID: 22520752

Title : Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer Methylene Blue - Triquigneaux_2012_Biochem.J_448_83
Author(s) : Triquigneaux MM , Ehrenshaft M , Roth E , Silman I , Ashani Y , Mason RP , Weiner L , Deterding LJ
Ref : Biochemical Journal , 448 :83 , 2012
Abstract :
PubMedSearch : Triquigneaux_2012_Biochem.J_448_83
PubMedID: 22888904

Title : Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis - Khare_2012_Nat.Chem.Biol_8_294
Author(s) : Khare SD , Kipnis Y , Greisen P, Jr. , Takeuchi R , Ashani Y , Goldsmith M , Song Y , Gallaher JL , Silman I , Leader H , Sussman JL , Stoddard BL , Tawfik DS , Baker D
Ref : Nat Chemical Biology , 8 :294 , 2012
Abstract :
PubMedSearch : Khare_2012_Nat.Chem.Biol_8_294
PubMedID: 22306579

Title : Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase - Paz_2012_Protein.Sci_21_1138
Author(s) : Paz A , Roth E , Ashani Y , Xu Y , Shnyrov VL , Sussman JL , Silman I , Weiner L
Ref : Protein Science , 21 :1138 , 2012
Abstract :
PubMedSearch : Paz_2012_Protein.Sci_21_1138
PubMedID: 22674800
Gene_locus related to this paper: torca-ACHE

Title : Directed evolution of hydrolases for prevention of G-type nerve agent intoxication - Gupta_2011_Nat.Chem.Biol_7_120
Author(s) : Gupta RD , Goldsmith M , Ashani Y , Simo Y , Mullokandov G , Bar H , Ben-David M , Leader H , Margalit R , Silman I , Sussman JL , Tawfik DS
Ref : Nat Chemical Biology , 7 :120 , 2011
Abstract :
PubMedSearch : Gupta_2011_Nat.Chem.Biol_7_120
PubMedID: 21217689

Title : In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases - Ashani_2011_Toxicol.Lett_206_24
Author(s) : Ashani Y , Goldsmith M , Leader H , Silman I , Sussman JL , Tawfik DS
Ref : Toxicol Lett , 206 :24 , 2011
Abstract :
PubMedSearch : Ashani_2011_Toxicol.Lett_206_24
PubMedID: 21807078

Title : Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers - Ashani_2010_Chem.Biol.Interact_187_362
Author(s) : Ashani Y , Gupta RD , Goldsmith M , Silman I , Sussman JL , Tawfik DS , Leader H
Ref : Chemico-Biological Interactions , 187 :362 , 2010
Abstract :
PubMedSearch : Ashani_2010_Chem.Biol.Interact_187_362
PubMedID: 20303930

Title : Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors - Weiner_2009_Biochemistry_48_563
Author(s) : Weiner L , Shnyrov VL , Konstantinovskii L , Roth E , Ashani Y , Silman I
Ref : Biochemistry , 48 :563 , 2009
Abstract :
PubMedSearch : Weiner_2009_Biochemistry_48_563
PubMedID: 19115961

Title : Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime - Sanson_2009_J.Med.Chem_52_7593
Author(s) : Sanson B , Nachon F , Colletier JP , Froment MT , Toker L , Greenblatt HM , Sussman JL , Ashani Y , Masson P , Silman I , Weik M
Ref : Journal of Medicinal Chemistry , 52 :7593 , 2009
Abstract :
PubMedSearch : Sanson_2009_J.Med.Chem_52_7593
PubMedID: 19642642
Gene_locus related to this paper: torca-ACHE

Title : The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates - Groner_2007_Mol.Pharmacol_71_1610
Author(s) : Groner E , Ashani Y , Schorer-Apelbaum D , Sterling J , Herzig Y , Weinstock M
Ref : Molecular Pharmacology , 71 :1610 , 2007
Abstract :
PubMedSearch : Groner_2007_Mol.Pharmacol_71_1610
PubMedID: 17347320

Title : Probing the molecular interaction of chymotrypsin with organophosphorus compounds by 31P diffusion NMR in aqueous solutions - Segev_2005_J.Org.Chem_70_309
Author(s) : Segev O , Columbus I , Ashani Y , Cohen Y
Ref : J Org Chem , 70 :309 , 2005
Abstract :
PubMedSearch : Segev_2005_J.Org.Chem_70_309
PubMedID: 15624938

Title : Estimation of the upper limit of human butyrylcholinesterase dose required for protection against organophosphates toxicity: a mathematically based toxicokinetic model - Ashani_2004_Toxicol.Sci_77_358
Author(s) : Ashani Y , Pistinner S
Ref : Toxicol Sci , 77 :358 , 2004
Abstract :
PubMedSearch : Ashani_2004_Toxicol.Sci_77_358
PubMedID: 14600276

Title : The effect of fluoride on the scavenging of organophosphates by human butyrylcholinesterase in buffer solutions and human plasma - Ashani_2004_Toxicol.Appl.Pharmacol_194_90
Author(s) : Ashani Y , Segev O , Balan A
Ref : Toxicol Appl Pharmacol , 194 :90 , 2004
Abstract :
PubMedSearch : Ashani_2004_Toxicol.Appl.Pharmacol_194_90
PubMedID: 14728983

Title : Human serum butyrylcholinesterase: A future generation antidote for organophosphate chemical warfare agent toxicity . -
Author(s) : Saxena A , Luo C , Bansal R , Sun W , Clark M , Ashani Y , Ross M , Doctor BP
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :269 , 2004
PubMedID:

Title : Poster (32) Bioscavengers: antidotes for organophosphate chemical warfare agent toxicity. -
Author(s) : Doctor BP , Saxena A , Ashani Y , Ross M
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :337 , 2004
PubMedID:

Title : Poster (34) Interaction of drugs and environmental factors with bioscavengers: does fluoride in human plasma affect the antidotal properties of human butyrylcholinesterase? -
Author(s) : Ashani Y , Balan A
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :338 , 2004
PubMedID:

Title : Poster (36) Human serum butyrylcholinesterase: a future generation antidote for organophosphate chemical warfare agent toxicity -
Author(s) : Saxena A , Luo C , Bansal R , Sun W , Clark M , Ashani Y , Ross M , Doctor BP
Ref : In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects , (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina :339 , 2004
PubMedID:

Title : Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators - Ashani_2003_Biochem.Pharmacol_66_191
Author(s) : Ashani Y , Bhattacharjee AK , Leader H , Saxena A , Doctor BP
Ref : Biochemical Pharmacology , 66 :191 , 2003
Abstract :
PubMedSearch : Ashani_2003_Biochem.Pharmacol_66_191
PubMedID: 12826262

Title : Pharmacokinetics and immunologic consequences of exposing macaques to purified homologous butyrylcholinesterase - Rosenberg_2002_Life.Sci_72_125
Author(s) : Rosenberg YJ , Luo C , Ashani Y , Doctor BP , Fischer R , Wolfe G , Saxena A
Ref : Life Sciences , 72 :125 , 2002
Abstract :
PubMedSearch : Rosenberg_2002_Life.Sci_72_125
PubMedID: 12417246

Title : Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime - Luo_1999_Chem.Biol.Interact_119-120_129
Author(s) : Luo C , Saxena A , Ashani Y , Leader H , Radic Z , Taylor P , Doctor BP
Ref : Chemico-Biological Interactions , 119-120 :129 , 1999
Abstract :
PubMedSearch : Luo_1999_Chem.Biol.Interact_119-120_129
PubMedID: 10421446

Title : Characterization of O,O-diethylphosphoryl oximes as inhibitors of cholinesterases and substrates of phosphotriesterases - Leader_1999_Biochem.Pharmacol_58_503
Author(s) : Leader H , Vincze A , Manisterski B , Rothschild N , Dosoretz C , Ashani Y
Ref : Biochemical Pharmacology , 58 :503 , 1999
Abstract :
PubMedSearch : Leader_1999_Biochem.Pharmacol_58_503
PubMedID: 10424771

Title : Acceleration of Oxime-Induced Reactivation of Organophosphate-Inhibited Fetal Bovine Serum Acetylcholinesterase by Monoquaternary and Bisquaternary Ligands - Luo_1998_Mol.Pharmacol_53_718
Author(s) : Luo C , Ashani Y , Doctor BP
Ref : Molecular Pharmacology , 53 :718 , 1998
Abstract :
PubMedSearch : Luo_1998_Mol.Pharmacol_53_718
PubMedID: 9547363

Title : Prophylaxis against soman inhalation toxicity in guinea pigs by pretreatment alone with human serum butyrylcholinesterase - Allon_1998_Toxicol.Sci_43_121
Author(s) : Allon N , Raveh L , Gilat E , Cohen E , Grunwald J , Ashani Y
Ref : Toxicol Sci , 43 :121 , 1998
Abstract :
PubMedSearch : Allon_1998_Toxicol.Sci_43_121
PubMedID: 9710953

Title : Acceleration of Oxime-Induced Reactivation of Organophosphate-Inhibited Acetylcholinesterase by Quaternary Ligands -
Author(s) : Luo C , Ashani Y , Saxena A , Leader H , Maxwell DM , Taylor P , Doctor BP
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :215 , 1998
PubMedID:

Title : Combined effect of organophosphorus hydrolase and oxime on the reactivation rate of diethylphosphoryl-acetylcholinesterase conjugates - Ashani_1998_Biochem.Pharmacol_55_159
Author(s) : Ashani Y , Leader H , Rothschild N , Dosoretz C
Ref : Biochemical Pharmacology , 55 :159 , 1998
Abstract :
PubMedSearch : Ashani_1998_Biochem.Pharmacol_55_159
PubMedID: 9448738

Title : Role of oligosaccharides in the pharmacokinetics of tissue-derived and genetically engineered cholinesterases - Saxena_1998_Mol.Pharmacol_53_112
Author(s) : Saxena A , Ashani Y , Raveh L , Stevenson D , Patel T , Doctor BP
Ref : Molecular Pharmacology , 53 :112 , 1998
Abstract :
PubMedSearch : Saxena_1998_Mol.Pharmacol_53_112
PubMedID: 9443938

Title : Current Capabilities in Extrapolating from Animal to Human the Capacity of Human Butyrylcholinesterase to Detoxify Organophosphates -
Author(s) : Ashani Y , Grauer E , Grunwald J , Allon N , Raveh L
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :255 , 1998
PubMedID:

Title : The Role of Oligosaccharides in the Pharmacokinetics of Cholinesterases -
Author(s) : Saxena A , Ashani Y , Raveh L , Doctor BP
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :283 , 1998
PubMedID:

Title : Acceleration of oxime-induced reactivation of acetylcholinesterase-organophosphate conjugate and 31P NMR detection of phosporyl oxime from the conjugate -
Author(s) : Luo C , Ashani Y , Doctor BP
Ref : Journal de Physiologie (Paris) , 92 :461 , 1998
PubMedID:

Title : Sequestration of Toxic Phosphorylated Oximes by Stoichiometric and Catalytic Scavengers -
Author(s) : Leader H , Vincze A , Rothschild N , Dosoretz C , Ashani Y
Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :305 , 1998
PubMedID:

Title : Structure of glycan moieties responsible for the extended circulatory life time of fetal bovine serum acetylcholinesterase and equine serum butyrylcholinesterase - Saxena_1997_Biochemistry_36_7481
Author(s) : Saxena A , Raveh L , Ashani Y , Doctor BP
Ref : Biochemistry , 36 :7481 , 1997
Abstract :
PubMedSearch : Saxena_1997_Biochemistry_36_7481
PubMedID: 9200697

Title : The stoichiometry of protection against soman and VX toxicity in monkeys pretreated with human butyrylcholinesterase - Raveh_1997_Toxicol.Appl.Pharmacol_145_43
Author(s) : Raveh L , Grauer E , Grunwald J , Cohen E , Ashani Y
Ref : Toxicol Appl Pharmacol , 145 :43 , 1997
Abstract :
PubMedSearch : Raveh_1997_Toxicol.Appl.Pharmacol_145_43
PubMedID: 9221822

Title : Large-scale purification and long-term stability of human butyrylcholinesterase: a potential bioscavenger drug - Grunwald_1997_J.Biochem.Biophys.Methods_34_123
Author(s) : Grunwald J , Marcus D , Papier Y , Raveh L , Pittel Z , Ashani Y
Ref : Journal of Biochemical & Biophysical Methods , 34 :123 , 1997
Abstract :
PubMedSearch : Grunwald_1997_J.Biochem.Biophys.Methods_34_123
PubMedID: 9178088

Title : Amino acid residues controlling reactivation of organophosphonyl conjugates of acetylcholinesterase by mono- and bisquaternary oximes - Ashani_1995_J.Biol.Chem_270_6370
Author(s) : Ashani Y , Radic Z , Tsigelny I , Vellom DC , Pickering NA , Quinn DM , Doctor BP , Taylor P
Ref : Journal of Biological Chemistry , 270 :6370 , 1995
Abstract :
PubMedSearch : Ashani_1995_J.Biol.Chem_270_6370
PubMedID: 7890775

Title : Modulation of Catalysis and Inhibition of Fetal Bovine Serum Acetylcholinesterase by Monoclonal Antibodies -
Author(s) : Doctor BP , Gentry MK , Saxena A , Ashani Y
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :141 , 1995
PubMedID:

Title : Amino Acid Residues that Control Mono- and Bisquaternary Oxime-Induced Reactivation of O-Ethyl Methylphosphonylated Cholinesterases -
Author(s) : Ashani Y , Radic Z , Tsigelny I , Vellom DC , Pickering NA , Quinn DM , Doctor BP , Taylor P
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :133 , 1995
PubMedID:

Title : Characterization of monoclonal antibodies that inhibit the catalytic activity of acetylcholinesterases - Gentry_1995_J.Neurochem_64_842
Author(s) : Gentry MK , Moorad DR , Hur RS , Saxena A , Ashani Y , Doctor BP
Ref : Journal of Neurochemistry , 64 :842 , 1995
Abstract :
PubMedSearch : Gentry_1995_J.Neurochem_64_842
PubMedID: 7830078

Title : Protection of Guinea Pigs against Soman Inhalation by Pretreatment Alone with Human Butyrylcholinesterase -
Author(s) : Allon N , Raveh L , Gilat E , Grunwald J , Manistersky E , Cohen E , Ashani Y
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :398 , 1995
PubMedID:

Title : Human Butyrylcholinesterase as Prophylaxis Treatment against Soman -
Author(s) : Grauer E , Raveh L , Kapon J , Grunwald J , Cohen E , Ashani Y
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :400 , 1995
PubMedID:

Title : Efficacy of Prophylaxis with Human Butyrylcholinesterase against Soman and VX Poisoning -
Author(s) : Raveh L , Grunwald J , Cohen E , Ashani Y
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :402 , 1995
PubMedID:

Title : Prevention of Brain Damage and Behavioral Performance Changes following an IV Injection of Soman and VX in Rats Pretreated with Human Butyrylcholinesterase -
Author(s) : Kadar T , Raveh L , Brandeis R , Grunwald J , Cohen E , Ashani Y
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :404 , 1995
PubMedID:

Title : Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase - Ashani_1994_Mol.Pharmacol_45_555
Author(s) : Ashani Y , Grunwald J , Kronman C , Velan B , Shafferman A
Ref : Molecular Pharmacology , 45 :555 , 1994
Abstract :
PubMedSearch : Ashani_1994_Mol.Pharmacol_45_555
PubMedID: 8145739
Gene_locus related to this paper: human-ACHE

Title : Amplification of the effectiveness of acetylcholinesterase for detoxification of organophosphorus compounds by bis-quaternary oximes - Caranto_1994_Biochem.Pharmacol_47_347
Author(s) : Caranto GR , Waibel KH , Asher JM , Larrison RW , Brecht KM , Schutz MB , Raveh L , Ashani Y , Wolfe AD , Maxwell DM , Doctor BP
Ref : Biochemical Pharmacology , 47 :347 , 1994
Abstract :
PubMedSearch : Caranto_1994_Biochem.Pharmacol_47_347
PubMedID: 8304979

Title : Huperzine A as a pretreatment candidate drug against nerve agent toxicity - Grunwald_1994_Life.Sci_54_991
Author(s) : Grunwald J , Raveh L , Doctor BP , Ashani Y
Ref : Life Sciences , 54 :991 , 1994
Abstract :
PubMedSearch : Grunwald_1994_Life.Sci_54_991
PubMedID: 8139389

Title : Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity. In vitro and in vivo quantitative characterization - Raveh_1993_Biochem.Pharmacol_45_2465
Author(s) : Raveh L , Grunwald J , Marcus D , Papier Y , Cohen E , Ashani Y
Ref : Biochemical Pharmacology , 45 :2465 , 1993
Abstract :
PubMedSearch : Raveh_1993_Biochem.Pharmacol_45_2465
PubMedID: 8328984

Title : Prevention of soman-induced cognitive deficits by pretreatment with human butyrylcholinesterase in rats - Brandeis_1993_Pharmacol.Biochem.Behav_46_889
Author(s) : Brandeis R , Raveh L , Grunwald J , Cohen E , Ashani Y
Ref : Pharmacol Biochem Behav , 46 :889 , 1993
Abstract :
PubMedSearch : Brandeis_1993_Pharmacol.Biochem.Behav_46_889
PubMedID: 8309970

Title : Immunochemical characterization of anti-acetylcholinesterase inhibitory monoclonal antibodies - Gentry_1993_Chem.Biol.Interact_87_227
Author(s) : Gentry MK , Saxena A , Ashani Y , Doctor BP
Ref : Chemico-Biological Interactions , 87 :227 , 1993
Abstract :
PubMedSearch : Gentry_1993_Chem.Biol.Interact_87_227
PubMedID: 7688272

Title : Direct observation and elucidation of the structures of aged and nonaged phosphorylated cholinesterases by 31P NMR spectroscopy - Segall_1993_Biochemistry_32_13441
Author(s) : Segall Y , Waysbort D , Barak D , Ariel N , Doctor BP , Grunwald J , Ashani Y
Ref : Biochemistry , 32 :13441 , 1993
Abstract :
PubMedSearch : Segall_1993_Biochemistry_32_13441
PubMedID: 8257680

Title : Protection against tabun toxicity in mice by prophylaxis with an enzyme hydrolyzing organophosphate esters - Raveh_1992_Biochem.Pharmacol_44_397
Author(s) : Raveh L , Segall Y , Leader H , Rothschild N , Levanon D , Henis Y , Ashani Y
Ref : Biochemical Pharmacology , 44 :397 , 1992
Abstract :
PubMedSearch : Raveh_1992_Biochem.Pharmacol_44_397
PubMedID: 1322669

Title : Mechanism of inhibition of cholinesterases by huperzine A - Ashani_1992_Biochem.Biophys.Res.Commun_184_719
Author(s) : Ashani Y , Peggins JO, 3rd , Doctor BP
Ref : Biochemical & Biophysical Research Communications , 184 :719 , 1992
Abstract :
PubMedSearch : Ashani_1992_Biochem.Biophys.Res.Commun_184_719
PubMedID: 1575745

Title : Cholinesterase and Carboxyl esterase as Scavengers for Organophosphorus Agents -
Author(s) : Maxwell DM , Wolfe AD , Ashani Y , Doctor BP
Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :206 , 1991
PubMedID:

Title : Enzymes as pretreatment drugs for organophosphate toxicity - Doctor_1991_Neurosci.Biobehav.Rev_15_123
Author(s) : Doctor BP , Raveh L , Wolfe AD , Maxwell DM , Ashani Y
Ref : Neurosci Biobehav Rev , 15 :123 , 1991
Abstract :
PubMedSearch : Doctor_1991_Neurosci.Biobehav.Rev_15_123
PubMedID: 2052184

Title : Butyrylcholinesterase and acetylcholinesterase prophylaxis against soman poisoning in mice - Ashani_1991_Biochem.Pharmacol_41_37
Author(s) : Ashani Y , Shapira S , Levy D , Wolfe AD , Doctor BP , Raveh L
Ref : Biochemical Pharmacology , 41 :37 , 1991
Abstract :
PubMedSearch : Ashani_1991_Biochem.Pharmacol_41_37
PubMedID: 1986743

Title : Changes in the Catalytic Activity of Acetylcholinesterase upon Complexation with Monoclonal Antibodies -
Author(s) : Ashani Y , Bromberg A , Levy D , Gentry MK , Brady DR , Doctor BP
Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :235 , 1991
PubMedID:

Title : Poster: Esterases as organophosphate scavengers -
Author(s) : Wolfe AD , Ashani Y , Doctor BP , Maxwell DM
Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :306 , 1991
PubMedID:

Title : Prophylaxis against organophosphate poisoning by an enzyme hydrolysing organophosphorus compounds in mice - Ashani_1991_Life.Sci_49_367
Author(s) : Ashani Y , Rothschild N , Segall Y , Levanon D , Raveh L
Ref : Life Sciences , 49 :367 , 1991
Abstract :
PubMedSearch : Ashani_1991_Life.Sci_49_367
PubMedID: 1649941

Title : Fetal Bovine Serum Acetylcholinesterase: Structure-Function Correlation -
Author(s) : Doctor BP , Gentry MK , Wu SJ , Ashani Y , De La Hoz DM
Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :37 , 1991
PubMedID:

Title : Refined crystal structures of aged and non-aged organophosphoryl conjugates of gamma-chymotrypsin - Harel_1991_J.Mol.Biol_221_909
Author(s) : Harel M , Su CT , Frolow F , Ashani Y , Silman I , Sussman JL
Ref : Journal of Molecular Biology , 221 :909 , 1991
Abstract :
PubMedSearch : Harel_1991_J.Mol.Biol_221_909
PubMedID: 1942036

Title : Poster: Physicochemical and crystallographic studies on the stability and structure of aged and nonaged organophosphoryl conjugates of chymotrypsin -
Author(s) : Su CT , Steinberg N , Silman I , Harel M , Sussman JL , Grunwald J , Ashani Y
Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :274 , 1991
PubMedID:

Title : Differences in conformational stability between native and phosphorylated acetylcholinesterase as evidenced by a monoclonal antibody - Ashani_1990_Biochemistry_29_2456
Author(s) : Ashani Y , Gentry MK , Doctor BP
Ref : Biochemistry , 29 :2456 , 1990
Abstract :
PubMedSearch : Ashani_1990_Biochemistry_29_2456
PubMedID: 1692236

Title : Acetylcholinesterase prophylaxis against organophosphate poisoning. Quantitative correlation between protection and blood-enzyme level in mice - Raveh_1989_Biochem.Pharmacol_38_529
Author(s) : Raveh L , Ashani Y , Levy D , De La Hoz DM , Wolfe AD , Doctor BP
Ref : Biochemical Pharmacology , 38 :529 , 1989
Abstract :
PubMedSearch : Raveh_1989_Biochem.Pharmacol_38_529
PubMedID: 2917010

Title : Conformational differences between aged and non-aged organophosphoryl conjugates of chymotrypsin -
Author(s) : Steinberg N , Grunwald J , Roth E , August R , Haas E , Ashani Y , Silman I
Ref : Prog Clin Biol Res , 289 :293 , 1989
PubMedID: 2726802

Title : Conformational differences between aged and nonaged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin as detected by optical spectroscopy - Steinberg_1989_Biochemistry_28_1248
Author(s) : Steinberg N , van der Drift AC , Grunwald J , Segall Y , Shirin E , Haas E , Ashani Y , Silman I
Ref : Biochemistry , 28 :1248 , 1989
Abstract :
PubMedSearch : Steinberg_1989_Biochemistry_28_1248
PubMedID: 2713362

Title : Structural and immunochemical properties of fetal bovine serum acetylcholinesterase -
Author(s) : Doctor BP , Smyth KK , Gentry MK , Ashani Y , Christner CE , De La Hoz DM , Ogert RA , Smith SW
Ref : Progress in Clinical & Biological Research , 289 :305 , 1989
PubMedID: 2471207

Title : Tritium labeling of a powerful methylphosphonate inhibitor of cholinesterase: synthesis and biological applications - Balan_1988_Anal.Biochem_169_95
Author(s) : Balan A , Barness I , Simon G , Levy D , Ashani Y
Ref : Analytical Biochemistry , 169 :95 , 1988
Abstract :
PubMedSearch : Balan_1988_Anal.Biochem_169_95
PubMedID: 88220750

Title : Synthesis and in vitro properties of a powerful quaternary methylphosphonate inhibitor of acetylcholinesterase. A new marker in blood-brain barrier research - Levy_1986_Biochem.Pharmacol_35_1079
Author(s) : Levy D , Ashani Y
Ref : Biochemical Pharmacology , 35 :1079 , 1986
Abstract :
PubMedSearch : Levy_1986_Biochem.Pharmacol_35_1079
PubMedID: 3754444

Title : Sugar conjugates of pyridinium aldoximes as antidotes against organophosphate poisoning - Heldman_1986_Carbohydr.Res_151_337
Author(s) : Heldman E , Ashani Y , Raveh L , Rachaman ES
Ref : Carbohydr Res , 151 :337 , 1986
Abstract :
PubMedSearch : Heldman_1986_Carbohydr.Res_151_337
PubMedID: 3768897

Title : In vitro and in vivo protection of acetylcholinesterase against organophosphate poisoning by pretreatment with a novel derivative of 1,3,2-dioxaphosphorinane 2-oxide - Ashani_1983_J.Med.Chem_26_145
Author(s) : Ashani Y , Leader H , Raveh L , Bruckstein R , Spiegelstein M
Ref : Journal of Medicinal Chemistry , 26 :145 , 1983
Abstract :
PubMedSearch : Ashani_1983_J.Med.Chem_26_145
PubMedID: 6827532

Title : Novel pyrene-containing organophosphates as fluorescent probes for studying aging-induced conformational changes in organophosphate-inhibited acetylcholinesterase -
Author(s) : Amitai G , Ashani Y , Gafni A , Silman I
Ref : Biochemistry , 21 :2060 , 1982
PubMedID: 7093230

Title : Fluorescent organophosphates: novel probes for studying aging-induced conformational changes in inhibited acetylcholinesterase and for localization of cholinesterase in nervous tissue - Amitai_1980_Monogr.Neural.Sci_7_70
Author(s) : Amitai G , Ashani Y , Shahar A , Gafni A , Silman I
Ref : Monographs in Neural Sciences , 7 :70 , 1980
Abstract :
PubMedSearch : Amitai_1980_Monogr.Neural.Sci_7_70
PubMedID: 7015117

Title : New fluorescent organophosphates as probes for studying aging-induced conformational changes in inhibited acetylcholinesterase - Amitai_1980_Neurochem.Int_2C_199
Author(s) : Amitai G , Ashani Y , Gafni A , Silman I
Ref : Neurochem Int , 2C :199 , 1980
Abstract :
PubMedSearch : Amitai_1980_Neurochem.Int_2C_199
PubMedID: 20487784

Title : Sugar-oximes, new potential antidotes against organophosphorus poisoning - Rachaman_1979_Arzneimittelforschung_29_875
Author(s) : Rachaman ES , Ashani Y , Leader H , Granoth I , Edery H , Porath G
Ref : Arzneimittelforschung , 29 :875 , 1979
Abstract :
PubMedSearch : Rachaman_1979_Arzneimittelforschung_29_875
PubMedID: 582776

Title : Purification of acetylcholinesterase by covalent affinity chromatography -
Author(s) : Voss HF , Ashani Y , Wilson IB
Ref : Advances in Experimental Medicine & Biology , 42 :75 , 1974
PubMedID: 4843798

Title : A covalent affinity technique for the purification of all forms of acetylcholinesterase -
Author(s) : Voss HF , Ashani Y , Wilson IB
Ref : Methods Enzymol , 34 :581 , 1974
PubMedID: 4476046

Title : Linear free energy relationships in the hydrolysis of some inhibitors of acetylcholinesterase -
Author(s) : Ashani Y , Snyder SL , Wilson IB
Ref : Journal of Medicinal Chemistry , 16 :446 , 1973
PubMedID: 4736963

Title : A covalent affinity column for the purification of acetylcholinesterase - Ashani_1972_Biochim.Biophys.Acta_276_317
Author(s) : Ashani Y , Wilson IB
Ref : Biochimica & Biophysica Acta , 276 :317 , 1972
Abstract :
PubMedSearch : Ashani_1972_Biochim.Biophys.Acta_276_317
PubMedID: 5047710

Title : Inhibition of cholinesterase by 1,3,2-dioxaphosphorinane 2-oxide derivatives -
Author(s) : Ashani Y , Snyder SL , Wilson IB
Ref : Biochemistry , 11 :3518 , 1972
PubMedID: 5066199

Title : The inhibition of cholinesterase by diethyl phosphorochloridate -
Author(s) : Ashani Y , Wins P , Wilson IB
Ref : Biochimica & Biophysica Acta , 284 :427 , 1972
PubMedID: 4673825

Title : A kinetic study of the reaction between 1,1'-trimethylenebis (4-hydroximinomethylpyridinium) dibromide and diisopropyl phosphorofluoridate -
Author(s) : Ashani Y , Cohen S
Ref : Journal of Medicinal Chemistry , 11 :967 , 1968
PubMedID: 5697106

Title : Reactivators of inhibited acetylcholinesterase. II. The preparation and properties of some new 4-hydroxyin-nomethyl-l-(N-aminoalkyl)-pyridinium salts -
Author(s) : Ashani Y , Cohen S
Ref : Israel Journal of Chemistry , 5 :59 , 1967
PubMedID:

Title : Reactivators of the inhibited acetylcholinesterase. 1. The preparation and properties of 4-hydroximino-methyl-1-methyl-pyridinium iodide -
Author(s) : Ashani Y , Ederey H , Zahavy J , Kunberg W , Cohen S
Ref : Israel Journal of Chemistry , 3 :133 , 1965
PubMedID: