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Structure Report for: 5ISM

Name|Human DPP4 in complex with a novel 5,5,6-tricyclic pyrrolidine inhibitor
Revelation date|11-May-2016
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 179 structure(s)
Gene_locus|human-DPP4
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Scapin, G
Ligand|


Reference

    Title: The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors
    Cox JM, Chu HD, Kuethe JT, Gao YD, Scapin G, Eiermann G, He H, Li X, Lyons KA and Biftu T <6 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, 26:2622, 2016 : PubMed

            



Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

no Image


Databases

PDB-Sum5ISM Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP5ISM Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP5ISM Structural Classification Of Protein - SCOP server
PROTEOPEDIA5ism 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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