| Title : The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors - Cox_2016_Bioorg.Med.Chem.Lett_26_2622 |
| Author(s) : Cox JM , Chu HD , Kuethe JT , Gao YD , Scapin G , Eiermann G , He H , Li X , Lyons KA , Metzger J , Petrov A , Wu JK , Xu S , Sinha-Roy R , Weber AE , Biftu T |
| Ref : Bioorganic & Medicinal Chemistry Lett , 26 :2622 , 2016 |
| Abstract : |
| PubMedSearch : Cox_2016_Bioorg.Med.Chem.Lett_26_2622 |
| PubMedID: 27106708 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes - Biftu_2014_J.Med.Chem_57_3205 |
| Author(s) : Biftu T , Sinha-Roy R , Chen P , Qian X , Feng D , Kuethe JT , Scapin G , Gao YD , Yan Y , Krueger D , Bak A , Eiermann G , He J , Cox J , Hicks J , Lyons K , He H , Salituro G , Tong S , Patel S , Doss G , Petrov A , Wu J , Xu SS , Sewall C , Zhang X , Zhang B , Thornberry NA , Weber AE |
| Ref : Journal of Medicinal Chemistry , 57 :3205 , 2014 |
| Abstract : |
| PubMedSearch : Biftu_2014_J.Med.Chem_57_3205 |
| PubMedID: 24660890 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design - Liang_2008_Bioorg.Med.Chem.Lett_18_3706 |
| Author(s) : Liang GB , Qian X , Biftu T , Singh S , Gao YD , Scapin G , Patel S , Leiting B , Patel R , Wu J , Zhang X , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :3706 , 2008 |
| Abstract : |
| PubMedSearch : Liang_2008_Bioorg.Med.Chem.Lett_18_3706 |
| PubMedID: 18524582 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes - Liang_2007_Bioorg.Med.Chem.Lett_17_1903 |
| Author(s) : Liang GB , Qian X , Feng D , Biftu T , Eiermann G , He H , Leiting B , Lyons K , Petrov A , Sinha-Roy R , Zhang B , Wu J , Zhang X , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :1903 , 2007 |
| Abstract : |
| PubMedSearch : Liang_2007_Bioorg.Med.Chem.Lett_17_1903 |
| PubMedID: 17291750 |
| Title : Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors - Gao_2007_Bioorg.Med.Chem.Lett_17_3877 |
| Author(s) : Gao YD , Feng D , Sheridan RP , Scapin G , Patel SB , Wu JK , Zhang X , Sinha-Roy R , Thornberry NA , Weber AE , Biftu T |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :3877 , 2007 |
| Abstract : |
| PubMedSearch : Gao_2007_Bioorg.Med.Chem.Lett_17_3877 |
| PubMedID: 17502141 |
| Title : (3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)- 1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Biftu_2007_Bioorg.Med.Chem.Lett_17_49 |
| Author(s) : Biftu T , Feng D , Qian X , Liang GB , Kieczykowski G , Eiermann G , He H , Leiting B , Lyons K , Petrov A , Sinha-Roy R , Zhang B , Scapin G , Patel S , Gao YD , Singh S , Wu J , Zhang X , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :49 , 2007 |
| Abstract : |
| PubMedSearch : Biftu_2007_Bioorg.Med.Chem.Lett_17_49 |
| PubMedID: 17055272 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin - Biftu_2007_Bioorg.Med.Chem.Lett_17_3384 |
| Author(s) : Biftu T , Scapin G , Singh S , Feng D , Becker JW , Eiermann G , He H , Lyons K , Patel S , Petrov A , Sinha-Roy R , Zhang B , Wu J , Zhang X , Doss GA , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :3384 , 2007 |
| Abstract : |
| PubMedSearch : Biftu_2007_Bioorg.Med.Chem.Lett_17_3384 |
| PubMedID: 17433672 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9 - Lankas_2005_Diabetes_54_2988 |
| Author(s) : Lankas GR , Leiting B , Roy RS , Eiermann GJ , Beconi MG , Biftu T , Chan CC , Edmondson S , Feeney WP , He H , Ippolito DE , Kim D , Lyons KA , Ok HO , Patel RA , Petrov AN , Pryor KA , Qian X , Reigle L , Woods A , Wu JK , Zaller D , Zhang X , Zhu L , Weber AE , Thornberry NA |
| Ref : Diabetes , 54 :2988 , 2005 |
| Abstract : |
| PubMedSearch : Lankas_2005_Diabetes_54_2988 |
| PubMedID: 16186403 |