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Structure Report for: 6R8Q

Name|Structure of the Wnt deacylase Notum in complex with a benzotriazole fragment JV5
Revelation date|08-May-2019
Family|Pectinacetylesterase-Notum: there are 695 genes in this family, 143 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Atkinson, B.N., Steadman, D., Zhao, Y., Sipthorp, J., Vecchia, L., Ruza, R.R., Jegnathan, F., Lines, G., Frew, S., Monaghan, A., Kjaer, S., Bictash, M., Jones, Y., Fish, P.V.
Ligand|Inhibitor: Benzotriazole-39-JV5 Ligand in structure: Ligplot


    Title: Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen
    Atkinson BN, Steadman D, Zhao YG, Sipthorp J, Vecchia L, Ruza RR, Jeganathan F, Lines G, Frew S and Jones EY <6 more author(s)>
    Ref: Medchemcomm, 10:1361, 2019 : PubMed


Representative scheme of Pectinacetylesterase-Notum structure and an image from PDBsum server

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PDB-Sum6R8Q Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6R8Q Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6R8Q Structural Classification Of Protein - SCOP server
PROTEOPEDIA6r8q 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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