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Structure Report for: 6U2M

Name|Crystal structure of a HaloTag-based calcium indicator, HaloCaMP V2, bound to JF635
Revelation date|30-Sep-2020
Family|Haloalkane_dehalogenase-HLD2: there are 72 genes in this family, 110 structure(s)
Gene_locus|rhoso-halo1
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Deo, C.,, Schreiter, E.R. the halo1 protein is extended with a calcium indicator from calmodulin
Ligand|Inhibitor: JF635 Ligand in structure: Ligplot


Reference

    Title: The HaloTag as a general scaffold for far-red tunable chemigenetic indicators
    Deo C, Abdelfattah AS, Bhargava HK, Berro AJ, Falco N, Farrants H, Moeyaert B, Chupanova M, Lavis LD, Schreiter ER
    Ref: Nat Chemical Biology, 17:718, 2021 : PubMed

            



Representative scheme of Haloalkane_dehalogenase-HLD2 structure and an image from PDBsum server



Databases

PDB-Sum6U2M Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6U2M Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6U2M Structural Classification Of Protein - SCOP server
PROTEOPEDIA6u2m 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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