11,12-EET
important dilator in a number of vascular beds. Synthetized by cytochrome P450 epoxygenase from arachidonic acid
General
Type : Epoxide, Fatty acid, Epoxy-fatty-acid
Chemical_Nomenclature : (5E,8E)-10-[3-[(E)-oct-2-enyl]oxiran-2-yl]deca-5,8-dienoic acid
Canonical SMILES : CCCCCC=CCC1C(O1)CC=CCC=CCCCC(=O)O
InChI : InChI=1S\/C20H32O3\/c1-2-3-4-5-9-12-15-18-19(23-18)16-13-10-7-6-8-11-14-17-20(21)22\/h6,8-10,12-13,18-19H,2-5,7,11,14-17H2,1H3,(H,21,22)\/b8-6+,12-9+,13-10+
InChIKey : DXOYQVHGIODESM-ATELOPIESA-N
Other name(s) : 11,12-epoxyeicosatrienoic acid || 11,12-Eet || 11,12-Oxido-5,8,14-eicosatrienoic acid || 11,12-epoxy-5,8,14-eicosatrienoic acid || 5,8-Decadienoic acid, 10-(3-(2-octenyl)oxiranyl)- || (5E,8E)-10-{3-[(2E)-oct-2-en-1-yl]oxiran-2-yl}deca-5,8-dienoic acid
MW : 320.47
Formula : C20H32O3
CAS_number : 123931-40-8, 81276-02-0
PubChem : 5353269
UniChem : DXOYQVHGIODESM-ATELOPIESA-N
Target
Structures : No structure
Families : Epoxide_hydrolase
References (9)
| Title : Putative receptors and signaling pathways responsible for the biological actions of epoxyeicosatrienoic acids - Edin_2025_J.Biol.Chem__110737 |
| Author(s) : Edin ML , Graves JP , Zeldin DC |
| Ref : Journal of Biological Chemistry , :110737 , 2025 |
| Abstract : |
| PubMedSearch : Edin_2025_J.Biol.Chem__110737 |
| PubMedID: 40975174 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Putative receptors and signaling pathways responsible for the biological actions of epoxyeicosatrienoic acids - Edin_2025_J.Biol.Chem__110737 |
| Author(s) : Edin ML , Graves JP , Zeldin DC |
| Ref : Journal of Biological Chemistry , :110737 , 2025 |
| Abstract : |
| PubMedSearch : Edin_2025_J.Biol.Chem__110737 |
| PubMedID: 40975174 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Putative receptors and signaling pathways responsible for the biological actions of epoxyeicosatrienoic acids - Edin_2025_J.Biol.Chem__110737 |
| Author(s) : Edin ML , Graves JP , Zeldin DC |
| Ref : Journal of Biological Chemistry , :110737 , 2025 |
| Abstract : |
| PubMedSearch : Edin_2025_J.Biol.Chem__110737 |
| PubMedID: 40975174 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Role of soluble epoxide hydrolase in age-related vascular cognitive decline - Nelson_2014_Prostaglandins.Other.Lipid.Mediat_113-115_30 |
| Author(s) : Nelson JW , Young JM , Borkar RN , Woltjer RL , Quinn JF , Silbert LC , Grafe MR , Alkayed NJ |
| Ref : Prostaglandins Other Lipid Mediat , 113-115 :30 , 2014 |
| Abstract : |
| PubMedSearch : Nelson_2014_Prostaglandins.Other.Lipid.Mediat_113-115_30 |
| PubMedID: 25277097 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Role of soluble epoxide hydrolase in age-related vascular cognitive decline - Nelson_2014_Prostaglandins.Other.Lipid.Mediat_113-115_30 |
| Author(s) : Nelson JW , Young JM , Borkar RN , Woltjer RL , Quinn JF , Silbert LC , Grafe MR , Alkayed NJ |
| Ref : Prostaglandins Other Lipid Mediat , 113-115 :30 , 2014 |
| Abstract : |
| PubMedSearch : Nelson_2014_Prostaglandins.Other.Lipid.Mediat_113-115_30 |
| PubMedID: 25277097 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Role of soluble epoxide hydrolase in age-related vascular cognitive decline - Nelson_2014_Prostaglandins.Other.Lipid.Mediat_113-115_30 |
| Author(s) : Nelson JW , Young JM , Borkar RN , Woltjer RL , Quinn JF , Silbert LC , Grafe MR , Alkayed NJ |
| Ref : Prostaglandins Other Lipid Mediat , 113-115 :30 , 2014 |
| Abstract : |
| PubMedSearch : Nelson_2014_Prostaglandins.Other.Lipid.Mediat_113-115_30 |
| PubMedID: 25277097 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides - Decker_2012_J.Lipid.Res_53_2038 |
| Author(s) : Decker M , Adamska M , Cronin A , Di Giallonardo F , Burgener J , Marowsky A , Falck JR , Morisseau C , Hammock BD , Gruzdev A , Zeldin DC , Arand M |
| Ref : J Lipid Res , 53 :2038 , 2012 |
| Abstract : |
| PubMedSearch : Decker_2012_J.Lipid.Res_53_2038 |
| PubMedID: 22798687 |
| Gene_locus related to this paper: human-EPHX3 , human-EPHX4 |
| Title : EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides - Decker_2012_J.Lipid.Res_53_2038 |
| Author(s) : Decker M , Adamska M , Cronin A , Di Giallonardo F , Burgener J , Marowsky A , Falck JR , Morisseau C , Hammock BD , Gruzdev A , Zeldin DC , Arand M |
| Ref : J Lipid Res , 53 :2038 , 2012 |
| Abstract : |
| PubMedSearch : Decker_2012_J.Lipid.Res_53_2038 |
| PubMedID: 22798687 |
| Gene_locus related to this paper: human-EPHX3 , human-EPHX4 |
| Title : EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides - Decker_2012_J.Lipid.Res_53_2038 |
| Author(s) : Decker M , Adamska M , Cronin A , Di Giallonardo F , Burgener J , Marowsky A , Falck JR , Morisseau C , Hammock BD , Gruzdev A , Zeldin DC , Arand M |
| Ref : J Lipid Res , 53 :2038 , 2012 |
| Abstract : |
| PubMedSearch : Decker_2012_J.Lipid.Res_53_2038 |
| PubMedID: 22798687 |
| Gene_locus related to this paper: human-EPHX3 , human-EPHX4 |