Acebutolol
General
Type : Pro-Drug || Drug || Not A\/B H target
Chemical_Nomenclature : N-[3-acetyl-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]butanamide
Canonical SMILES : CCCC(=O)NC1=CC(=C(C=C1)OCC(CNC(C)C)O)C(=O)C
InChI : InChI=1S\/C18H28N2O4\/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3\/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23)
InChIKey : GOEMGAFJFRBGGG-UHFFFAOYSA-N
Other name(s) : Acetobutolol, dl-Acebutolol, Neptal, DB01193, CHEBI:2379, CHEMBL642, SCHEMBL3772
Target
Families : Carb_B_Chordata
References (3)
| Title : Evaluation of drug-drug interactions via inhibition of hydrolases by orlistat, an anti-obesity drug - Hirosawa_2023_Drug.Metab.Dispos__ |
| Author(s) : Hirosawa K , Fukami T , Nakano M , Nakajima M |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , : , 2023 |
| PubMedID: 37137721 |
| Title : A proposed mechanism for the adverse effects of acebutolol: CES2 and CYP2C19-mediated metabolism and antinuclear antibody production - Muta_2015_Biochem.Pharmacol_98_659 |
| Author(s) : Muta K , Fukami T , Nakajima M |
| Ref : Biochemical Pharmacology , 98 :659 , 2015 |
| PubMedID: 26408002 |
| Title : A comparison of the experimental anti-arrhythmic properties of acebutolol (M and B 17,803), propranolol and practolol - Basil_1974_Br.J.Pharmacol_50_323 |
| Author(s) : Basil B , Jordan R , Loveless AH , Maxwell DR |
| Ref : British Journal of Pharmacology , 50 :323 , 1974 |
| PubMedID: 4850183 |