CLsuGG
General
Type : Antibiotic, Drug, pNP, Pro-Drug
Chemical_Nomenclature :
Canonical SMILES : O(C(CCC(NCC(NCC(O)=O)=O)=O)=O)CC(C(O)C1=CC=C([N+](=O)[O-])C=C1)NC(C(Cl)Cl)=O
InChI : InChI=1S\/C19H22Cl2N4O10\/c20-18(21)19(32)24-12(17(31)10-1-3-11(4-2-10)25(33)34)9-35-16(30)6-5-13(26)22-7-14(27)23-8-15(28)29\/h1-4,12,17-18,31H,5-9H2,(H,22,26)(H,23,27)(H,24,32)(H,28,29)
InChIKey : OPBSDKCRISMGAY-UHFFFAOYSA-N
Other name(s) : diglycine chloramphenicol succinate
Target
Structures : No structure
Families : yjfP_esterase-like, BioH
References (2)
| Title : Structure-Activity Relationship of Peptide-Conjugated Chloramphenicol for Inhibiting Escherichia coli - Wang_2019_J.Med.Chem_62_10245 |
| Author(s) : Wang J , Shy A , Wu D , Cooper DL , Xu J , He H , Zhan W , Sun S , Lovett ST , Xu B |
| Ref : Journal of Medicinal Chemistry , 62 :10245 , 2019 |
| Abstract : |
| PubMedSearch : Wang_2019_J.Med.Chem_62_10245 |
| PubMedID: 31670952 |
| Title : Diglycine Enables Rapid Intrabacterial Hydrolysis for Activating Anbiotics against Gram-negative Bacteria - Wang_2019_Angew.Chem.Int.Ed.Engl_58_10631 |
| Author(s) : Wang J , Cooper DL , Zhan W , Wu D , He H , Sun S , Lovett ST , Xu B |
| Ref : Angew Chem Int Ed Engl , 58 :10631 , 2019 |
| Abstract : |
| PubMedSearch : Wang_2019_Angew.Chem.Int.Ed.Engl_58_10631 |
| PubMedID: 31167041 |
| Gene_locus related to this paper: ecoli-bioh , ecoli-yjfp |