Escherichia coli, Escherichia fergusonii, Escherichia albertii, Escherichia sp., biotin biosynthesis bioh bioH2
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. E.coli employs a methylation and demethylation strategy to allow elongation of a temporarily disguised malonate moiety to a pimelate moiety by the fatty acid synthetic enzymes. BioH shows a preference for short chain fatty acid esters (acyl chain length of up to 6 carbons) and short chain p-nitrophenyl esters. Also displays a weak thioesterase activity. Can form a complex with CoA, and may be involved in the condensation of CoA and pimelic acid into pimeloyl-CoA, a precursor in biotin biosynthesis. Catalyzes the hydrolysis of the methyl ester bond of dimethylbutyryl-S-methyl mercaptopropionate (DMB-S-MMP) to yield dimethylbutyryl mercaptopropionic acid (DMBS-MPA) during the biocatalytic conversion of simvastin acid from monacolin J acid. Can also use acyl carriers such as dimethylbutyryl-S-ethyl mercaptopropionate (DMB-S-EMP) and dimethylbutyryl-S-methyl thioglycolate (DMB-S-MTG) as the thioester substrates.
Family : BioH
Block : X
Position in NCBI Life Tree : Escherichia coli
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > Proteobacteria N E > Gammaproteobacteria N E > Enterobacterales N E > Enterobacteriaceae N E > Escherichia N E > Escherichia coli N EMNNIWWQTKG QGNVHLVLLH GWGLNAEVWR CIDEELSSHF TLHLVDLPGF GRSRGFGALS LADMAEAVLQ QAPDKAIWLG WSLGGLVASQ IALTHPERVQ ALVTVASSPC FSARDEWPGI KPDVLAGFQQ QLSDDFQRTV ERFLALQTMG TETARQDARA LKKTVLALPM PEVDVLNGGL EILKTVDLRQ PLQNVSMPFL RLYGYLDGLV PRKVVPMLDK LWPHSESYIF AKAAHAPFIS HPAEFCHLLV ALKQRV
Title : Controlling enantioselectivity of esterase in asymmetric hydrolysis of aryl prochiral diesters by introducing aromatic interactions - Guo_2014_Biotechnol.Bioeng_111_1729 |
Author(s) : Guo F , Franzen S , Ye L , Gu J , Yu H |
Ref : Biotechnol Bioeng , 111 :1729 , 2014 |
Abstract : |
PubMedSearch : Guo_2014_Biotechnol.Bioeng_111_1729 |
PubMedID: 24737244 |
Gene_locus related to this paper: ecoli-bioh , rhos4-q3j2v1 |
Title : Optical mapping and sequencing of the Escherichia coli KO11 genome reveal extensive chromosomal rearrangements, and multiple tandem copies of the Zymomonas mobilis pdc and adhB genes - Turner_2012_J.Ind.Microbiol.Biotechnol_39_629 |
Author(s) : Turner PC , Yomano LP , Jarboe LR , York SW , Baggett CL , Moritz BE , Zentz EB , Shanmugam KT , Ingram LO |
Ref : J Ind Microbiol Biotechnol , 39 :629 , 2012 |
Abstract : |
PubMedSearch : Turner_2012_J.Ind.Microbiol.Biotechnol_39_629 |
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Title : Structure of the enzyme-acyl carrier protein (ACP) substrate gatekeeper complex required for biotin synthesis - Agarwal_2012_Proc.Natl.Acad.Sci.U.S.A_109_17406 |
Author(s) : Agarwal V , Lin S , Lukk T , Nair SK , Cronan JE |
Ref : Proc Natl Acad Sci U S A , 109 :17406 , 2012 |
Abstract : |
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Title : Complete genome sequence of adherent invasive Escherichia coli UM146 isolated from Ileal Crohn's disease biopsy tissue - Krause_2011_J.Bacteriol_193_583 |
Author(s) : Krause DO , Little AC , Dowd SE , Bernstein CN |
Ref : Journal of Bacteriology , 193 :583 , 2011 |
Abstract : |
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Title : Draft genome sequences of six Escherichia coli isolates from the stepwise model of emergence of Escherichia coli O157:H7 - Rump_2011_J.Bacteriol_193_2058 |
Author(s) : Rump LV , Strain EA , Cao G , Allard MW , Fischer M , Brown EW , Gonzalez-Escalona N |
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Abstract : |
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Title : Biotin synthesis begins by hijacking the fatty acid synthetic pathway. - Lin_2010_Nat.Chem.Biol_6_682 |
Author(s) : Lin S , Hanson RE , Cronan JE |
Ref : Nat Chemical Biology , 6 :682 , 2010 |
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Title : Host imprints on bacterial genomes--rapid, divergent evolution in individual patients - Zdziarski_2010_PLoS.Pathog_6_e1001078 |
Author(s) : Zdziarski J , Brzuszkiewicz E , Wullt B , Liesegang H , Biran D , Voigt B , Gronberg-Hernandez J , Ragnarsdottir B , Hecker M , Ron EZ , Daniel R , Gottschalk G , Hacker J , Svanborg C , Dobrindt U |
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Abstract : |
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Title : Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes - Nash_2010_BMC.Genomics_11_667 |
Author(s) : Nash JH , Villegas A , Kropinski AM , Aguilar-Valenzuela R , Konczy P , Mascarenhas M , Ziebell K , Torres AG , Karmali MA , Coombes BK |
Ref : BMC Genomics , 11 :667 , 2010 |
Abstract : |
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Title : A commensal gone bad: complete genome sequence of the prototypical enterotoxigenic Escherichia coli strain H10407 - Crossman_2010_J.Bacteriol_192_5822 |
Author(s) : Crossman LC , Chaudhuri RR , Beatson SA , Wells TJ , Desvaux M , Cunningham AF , Petty NK , Mahon V , Brinkley C , Hobman JL , Savarino SJ , Turner SM , Pallen MJ , Penn CW , Parkhill J , Turner AK , Johnson TJ , Thomson NR , Smith SG , Henderson IR |
Ref : Journal of Bacteriology , 192 :5822 , 2010 |
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Title : Characterization of the contribution to virulence of three large plasmids of avian pathogenic Escherichia coli chi7122 (O78:K80:H9) - Mellata_2010_Infect.Immun_78_1528 |
Author(s) : Mellata M , Ameiss K , Mo H , Curtiss R, 3rd |
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Title : Derivation of Escherichia coli O157:H7 from its O55:H7 precursor - Zhou_2010_PLoS.One_5_e8700 |
Author(s) : Zhou Z , Li X , Liu B , Beutin L , Xu J , Ren Y , Feng L , Lan R , Reeves PR , Wang L |
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Title : Complete genome sequence of the wild-type commensal Escherichia coli strain SE15, belonging to phylogenetic group B2 - Toh_2010_J.Bacteriol_192_1165 |
Author(s) : Toh H , Oshima K , Toyoda A , Ogura Y , Ooka T , Sasamoto H , Park SH , Iyoda S , Kurokawa K , Morita H , Itoh K , Taylor TD , Hayashi T , Hattori M |
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Title : Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042 - Chaudhuri_2010_PLoS.One_5_e8801 |
Author(s) : Chaudhuri RR , Sebaihia M , Hobman JL , Webber MA , Leyton DL , Goldberg MD , Cunningham AF , Scott-Tucker A , Ferguson PR , Thomas CM , Frankel G , Tang CM , Dudley EG , Roberts IS , Rasko DA , Pallen MJ , Parkhill J , Nataro JP , Thomson NR , Henderson IR |
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Title : Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348\/69 - Iguchi_2009_J.Bacteriol_191_347 |
Author(s) : Iguchi A , Thomson NR , Ogura Y , Saunders D , Ooka T , Henderson IR , Harris D , Asadulghani M , Kurokawa K , Dean P , Kenny B , Quail MA , Thurston S , Dougan G , Hayashi T , Parkhill J , Frankel G |
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Title : Genomic sequencing reveals regulatory mutations and recombinational events in the widely used MC4100 lineage of Escherichia coli K-12 - Ferenci_2009_J.Bacteriol_191_4025 |
Author(s) : Ferenci T , Zhou Z , Betteridge T , Ren Y , Liu Y , Feng L , Reeves PR , Wang L |
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Title : Genome sequences of Escherichia coli B strains REL606 and BL21(DE3) - Jeong_2009_J.Mol.Biol_394_644 |
Author(s) : Jeong H , Barbe V , Lee CH , Vallenet D , Yu DS , Choi SH , Couloux A , Lee SW , Yoon SH , Cattolico L , Hur CG , Park HS , Segurens B , Kim SC , Oh TK , Lenski RE , Studier FW , Daegelen P , Kim JF |
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Title : Comparative genomics reveal the mechanism of the parallel evolution of O157 and non-O157 enterohemorrhagic Escherichia coli - Ogura_2009_Proc.Natl.Acad.Sci.U.S.A_106_17939 |
Author(s) : Ogura Y , Ooka T , Iguchi A , Toh H , Asadulghani M , Oshima K , Kodama T , Abe H , Nakayama K , Kurokawa K , Tobe T , Hattori M , Hayashi T |
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Abstract : |
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Title : A precise reconstruction of the emergence and constrained radiations of Escherichia coli O157 portrayed by backbone concatenomic analysis - Leopold_2009_Proc.Natl.Acad.Sci.U.S.A_106_8713 |
Author(s) : Leopold SR , Magrini V , Holt NJ , Shaikh N , Mardis ER , Cagno J , Ogura Y , Iguchi A , Hayashi T , Mellmann A , Karch H , Besser TE , Sawyer SA , Whittam TS , Tarr PI |
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Abstract : |
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Title : The pangenome structure of Escherichia coli: comparative genomic analysis of E. coli commensal and pathogenic isolates - Rasko_2008_J.Bacteriol_190_6881 |
Author(s) : Rasko DA , Rosovitz MJ , Myers GS , Mongodin EF , Fricke WF , Gajer P , Crabtree J , Sebaihia M , Thomson NR , Chaudhuri R , Henderson IR , Sperandio V , Ravel J |
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Abstract : |
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Title : The complete genome sequence of Escherichia coli DH10B: insights into the biology of a laboratory workhorse - Durfee_2008_J.Bacteriol_190_2597 |
Author(s) : Durfee T , Nelson R , Baldwin S , Plunkett G, 3rd , Burland V , Mau B , Petrosino JF , Qin X , Muzny DM , Ayele M , Gibbs RA , Csorgo B , Posfai G , Weinstock GM , Blattner FR |
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Abstract : |
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Title : Complete genome sequence and comparative analysis of the wild-type commensal Escherichia coli strain SE11 isolated from a healthy adult - Oshima_2008_DNA.Res_15_375 |
Author(s) : Oshima K , Toh H , Ogura Y , Sasamoto H , Morita H , Park SH , Ooka T , Iyoda S , Taylor TD , Hayashi T , Itoh K , Hattori M |
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Abstract : |
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Title : Insights into the environmental resistance gene pool from the genome sequence of the multidrug-resistant environmental isolate Escherichia coli SMS-3-5 - Fricke_2008_J.Bacteriol_190_6779 |
Author(s) : Fricke WF , Wright MS , Lindell AH , Harkins DM , Baker-Austin C , Ravel J , Stepanauskas R |
Ref : Journal of Bacteriology , 190 :6779 , 2008 |
Abstract : |
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Title : The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes - Johnson_2007_J.Bacteriol_189_3228 |
Author(s) : Johnson TJ , Kariyawasam S , Wannemuehler Y , Mangiamele P , Johnson SJ , Doetkott C , Skyberg JA , Lynne AM , Johnson JR , Nolan LK |
Ref : Journal of Bacteriology , 189 :3228 , 2007 |
Abstract : |
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PubMedID: 17293413 |
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Title : Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach - Chen_2006_Proc.Natl.Acad.Sci.U.S.A_103_5977 |
Author(s) : Chen SL , Hung CS , Xu J , Reigstad CS , Magrini V , Sabo A , Blasiar D , Bieri T , Meyer RR , Ozersky P , Armstrong JR , Fulton RS , Latreille JP , Spieth J , Hooton TM , Mardis ER , Hultgren SJ , Gordon JI |
Ref : Proc Natl Acad Sci U S A , 103 :5977 , 2006 |
Abstract : |
PubMedSearch : Chen_2006_Proc.Natl.Acad.Sci.U.S.A_103_5977 |
PubMedID: 16585510 |
Gene_locus related to this paper: ecoli-Aes , ecoli-rutD , ecoli-bioh , ecoli-C0410 , ecoli-C2429 , ecoli-C2451 , ecoli-C4836 , ecoli-dlhh , ecoli-entf , ecoli-fes , ecoli-IROD , ecoli-IROE , ecoli-pldb , ecoli-ptrb , ecoli-yafa , ecoli-yaim , ecoli-ybff , ecoli-ycfp , ecoli-ycjy , ecoli-yeiG , ecoli-YFBB , ecoli-yghX , ecoli-yhet , ecoli-yiel , ecoli-yjfp , ecoli-YNBC , ecoli-ypfh , ecoli-ypt1 , ecoli-yqia , ecoli-YfhR , ecout-q1r7l6 , yerpe-YBTT |
Title : Role of pathogenicity island-associated integrases in the genome plasticity of uropathogenic Escherichia coli strain 536 - Hochhut_2006_Mol.Microbiol_61_584 |
Author(s) : Hochhut B , Wilde C , Balling G , Middendorf B , Dobrindt U , Brzuszkiewicz E , Gottschalk G , Carniel E , Hacker J |
Ref : Molecular Microbiology , 61 :584 , 2006 |
Abstract : |
PubMedSearch : Hochhut_2006_Mol.Microbiol_61_584 |
PubMedID: 16879640 |
Gene_locus related to this paper: ecoli-Aes , ecoli-rutD , ecoli-bioh , ecoli-C0410 , ecoli-C2429 , ecoli-C2451 , ecoli-C4836 , ecoli-dlhh , ecoli-entf , ecoli-fes , ecoli-IROD , ecoli-IROE , ecoli-pldb , ecoli-ptrb , ecoli-yafa , ecoli-yaim , ecoli-ybff , ecoli-ycfp , ecoli-ycjy , ecoli-yeiG , ecoli-YFBB , ecoli-yghX , ecoli-yhet , ecoli-yiel , ecoli-yjfp , ecoli-YNBC , ecoli-ypfh , ecoli-yqia , ecoli-YfhR , ecolx-q707d7 , yerpe-YBTT |
Title : Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli - Sanishvili_2003_J.Biol.Chem_278_26039 |
Author(s) : Sanishvili R , Yakunin AF , Laskowski RA , Skarina T , Evdokimova E , Doherty-Kirby A , Lajoie GA , Thornton JM , Arrowsmith CH , Savchenko A , Joachimiak A , Edwards AM |
Ref : Journal of Biological Chemistry , 278 :26039 , 2003 |
Abstract : |
PubMedSearch : Sanishvili_2003_J.Biol.Chem_278_26039 |
PubMedID: 12732651 |
Gene_locus related to this paper: ecoli-bioh |
Title : Purification and characterisation of the BIOH protein from the biotin biosynthetic pathway - Tomczyk_2002_FEBS.Lett_513_299 |
Author(s) : Tomczyk NH , Nettleship JE , Baxter RL , Crichton HJ , Webster SP , Campopiano DJ |
Ref : FEBS Letters , 513 :299 , 2002 |
Abstract : |
PubMedSearch : Tomczyk_2002_FEBS.Lett_513_299 |
PubMedID: 11904168 |
Gene_locus related to this paper: ecoli-bioh , neime-NMA2216 |
Title : Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12 - Hayashi_2001_DNA.Res_8_11 |
Author(s) : Hayashi T , Makino K , Ohnishi M , Kurokawa K , Ishii K , Yokoyama K , Han CG , Ohtsubo E , Nakayama K , Murata T , Tanaka M , Tobe T , Iida T , Takami H , Honda T , Sasakawa C , Ogasawara N , Yasunaga T , Kuhara S , Shiba T , Hattori M , Shinagawa H |
Ref : DNA Research , 8 :11 , 2001 |
Abstract : |
PubMedSearch : Hayashi_2001_DNA.Res_8_11 |
PubMedID: 11258796 |
Gene_locus related to this paper: ecoli-rutD , ecoli-bioh , ecoli-C0410 , ecoli-entf , ecoli-fes , ecoli-MCMK , ecoli-mhpc , ecoli-pldb , ecoli-ptrb , ecoli-yafa , ecoli-yaim , ecoli-ybff , ecoli-ycfp , ecoli-ycjy , ecoli-YFBB , ecoli-yghX , ecoli-yhet , ecoli-yjfp , ecoli-YNBC , ecoli-ypfh , ecoli-yqia , ecoli-Z0347 , ecoli-Z1341 , ecoli-Z1930 , ecoli-Z2445 , ecoli-YfhR |
Title : Genome sequence of enterohaemorrhagic Escherichia coli O157:H7 - Perna_2001_Nature_409_529 |
Author(s) : Perna NT , Plunkett G, 3rd , Burland V , Mau B , Glasner JD , Rose DJ , Mayhew GF , Evans PS , Gregor J , Kirkpatrick HA , Posfai G , Hackett J , Klink S , Boutin A , Shao Y , Miller L , Grotbeck EJ , Davis NW , Lim A , Dimalanta ET , Potamousis KD , Apodaca J , Anantharaman TS , Lin J , Yen G , Schwartz DC , Welch RA , Blattner FR |
Ref : Nature , 409 :529 , 2001 |
Abstract : |
PubMedSearch : Perna_2001_Nature_409_529 |
PubMedID: 11206551 |
Gene_locus related to this paper: ecoli-Aes , ecoli-rutD , ecoli-bioh , ecoli-C0410 , ecoli-dlhh , ecoli-entf , ecoli-fes , ecoli-MCMK , ecoli-mhpc , ecoli-pldb , ecoli-ptrb , ecoli-yafa , ecoli-yaim , ecoli-ybff , ecoli-ycfp , ecoli-ycjy , ecoli-yeiG , ecoli-YFBB , ecoli-yhet , ecoli-yjfp , ecoli-YNBC , ecoli-ypfh , ecoli-yqia , ecoli-Z0347 , ecoli-Z1341 , ecoli-Z1930 , ecoli-Z2445 , ecoli-YfhR |
Title : The complete genome sequence of Escherichia coli K-12 - Blattner_1997_Science_277_1453 |
Author(s) : Blattner FR , Plunkett G, 3rd , Bloch CA , Perna NT , Burland V , Riley M , Collado-Vides J , Glasner JD , Rode CK , Mayhew GF , Gregor J , Davis NW , Kirkpatrick HA , Goeden MA , Rose DJ , Mau B , Shao Y |
Ref : Science , 277 :1453 , 1997 |
Abstract : |
PubMedSearch : Blattner_1997_Science_277_1453 |
PubMedID: 9278503 |
Gene_locus related to this paper: ecoli-Aes , ecoli-bioh , ecoli-dlhh , ecoli-entf , ecoli-fes , ecoli-mhpc , ecoli-yafa , ecoli-yaim , ecoli-ybff , ecoli-ycfp , ecoli-ycjy , ecoli-yeiG , ecoli-YFBB , ecoli-yghX , ecoli-yhet , ecoli-yiel , ecoli-yjfp , ecoli-YNBC , ecoli-ypfh , ecoli-yqia , ecoli-YfhR |
Title : Nucleotide sequence of the bioH gene of Escherichia coli - |
Author(s) : O'Regan M , Gloeckler R , Bernard S , Ledoux C , Ohsawa I , Lemoine Y |
Ref : Nucleic Acids Research , 17 :8004 , 1989 |
PubMedID: 2678009 |
Gene_locus related to this paper: ecoli-bioh |