Dabcyl-EARRGLE-edans

Mimics Hip1's natural cleavage site in its biological substrate, GroEL2 between the R-G peptide bond results in an increase in fluorescence at 490 nM.Dabcyl fluorescens is quenched by EDANS until cleavage separate them

General

Type : Peptide, FRET-Peptide, Fluorescent Probe, Naphthalen

Chemical_Nomenclature :

Canonical SMILES : N(C(C(NC(C(NC(C(NC(C(NCC(NC(C(NC(C(=O)NCCNC1=CC=CC2=C1C=CC=C2[S](=O)(=O)O)CCC(=O)O)=O)CC(C)C)=O)=O)CCCNC(N)N)=O)CCCNC(N)N)=O)C)=O)CCC(O)=O)C(=O)C3=CC=C(C=C3)N=NC4=CC=C(C=C4)N(C)C

InChI : InChI=1S\/C60H88N18O15S\/c1-34(2)32-47(58(90)75-45(24-26-50(80)81)54(86)66-31-30-65-42-12-6-11-41-40(42)10-7-15-48(41)94(91,92)93)71-49(79)33-69-55(87)43(13-8-28-67-59(61)62)74-57(89)44(14-9-29-68-60(63)64)72-52(84)35(3)70-56(88)46(25-27-51(82)83)73-53(85)36-16-18-37(19-17-36)76-77-38-20-22-39(23-21-38)78(4)5\/h6-7,10-12,15-23,34-35,43-47,59-60,65,67-68H,8-9,13-14,24-33,61-64H2,1-5H3,(H,66,86)(H,69,87)(H,70,88)(H,71,79)(H,72,84)(H,73,85)(H,74,89)(H,75,90)(H,80,81)(H,82,83)(H,91,92,93)

InChIKey : BVFJPUZRLNUCIY-UHFFFAOYSA-N

Other name(s) : Dabcyl-Glu-Ala-Arg-Arg-Gly-Leu-Glu-(EDANS)-R(OH)  ||  Dabcyl-E-A-R-R-G-L-E-(EDANS)-R(OH)  ||  4-(4'-Dimethylaminophenylazo)benzoyl-glutamyl-alanyl-arginyl-arginyl-glycyl-leucyl-glutamyl-5((2-aminoethyl)amino)naphthalene-1-sulfonic acid


MW : 1333.52

Formula : C60H88N18O15S

CAS_number :

PubChem :

UniChem : BVFJPUZRLNUCIY-UHFFFAOYSA-N

Target

Structures : No structure

Families : Tiancimycin-TnmK-Tripeptidase-HIP

References (1)

Title : 2.1 A crystal structure of the Mycobacterium tuberculosis serine hydrolase, Hip1, in its anhydro-form (Anhydrohip1) - Brooks_2022_Biochem.Biophys.Res.Commun_630_57
Author(s) : Brooks CL , Ostrov DA , Schumann NC , Kakkad S , Li D , Pena K , Williams BP , Goldfarb NE
Ref : Biochemical & Biophysical Research Communications , 630 :57 , 2022
Abstract :
PubMedSearch : Brooks_2022_Biochem.Biophys.Res.Commun_630_57
PubMedID: 36148729
Gene_locus related to this paper: myctu-ym24