DiFMU-octanoate
fluorogenic and chromogenic substrates for diacylglycerol lipase
General
Type : Coumarin, Fluorescent Probe, DifMU derivative, Chromen
Chemical_Nomenclature : (6,8-difluoro-4-methyl-2-oxochromen-7-yl) octanoate
Canonical SMILES : CCCCCCCC(=O)OC1=C(C=C2C(=CC(=O)OC2=C1F)C)F
InChI : InChI=1S\/C18H20F2O4\/c1-3-4-5-6-7-8-14(21)23-18-13(19)10-12-11(2)9-15(22)24-17(12)16(18)20\/h9-10H,3-8H2,1-2H3
InChIKey : NILOHUULNWRMEL-UHFFFAOYSA-N
Other name(s) : SCHEMBL2513173 || DiFMU octanoate || DiFMUO || difluoro-methyl-umbelliferyl-octanoate || 6,8-difluoro-4-methylumbelliferyl octanoate
MW : 338.34
Formula : C18H20F2O4
CAS_number :
PubChem : 59197556
UniChem : NILOHUULNWRMEL-UHFFFAOYSA-N
Target
Structures : No structure
Families : Lipase_3, Canar_LipB, S9N_PREPL_Peptidase_S9
References (4)
| Title : Missense variants in CMS22 patients reveal that PREPL has both enzymatic and non-enzymatic functions - Monnens_2024_JCI.Insight__e179276 |
| Author(s) : Monnens Y , Theodoropoulou A , Rosier K , Bhalla K , Mahy A , Vanhoutte R , Meulemans S , Cavani E , Antanasijevic A , Lemmens I , Lee JA , Spellicy CJ , Schroer RJ , Maselli RA , Laverty CG , Agostinis P , Pagliarini DJ , Verhelst S , Marcaida MJ , Rochtus A , Dal Peraro M , Creemers JW |
| Ref : JCI Insight , : , 2024 |
| Abstract : |
| PubMedSearch : Monnens_2024_JCI.Insight__e179276 |
| PubMedID: 39078710 |
| Gene_locus related to this paper: human-PREPL |
| Title : A novel live cell assay to measure diacylglycerol lipase alpha activity - Singh_2016_Biosci.Rep_36_ |
| Author(s) : Singh PK , Markwick R , Howell FV , Williams G , Doherty P |
| Ref : Bioscience Reports , 36 : , 2016 |
| Abstract : |
| PubMedSearch : Singh_2016_Biosci.Rep_36_ |
| PubMedID: 27013337 |
| Gene_locus related to this paper: human-DAGLA |
| Title : Molecular characterization and identification of surrogate substrates for diacylglycerol lipase alpha - Pedicord_2011_Biochem.Biophys.Res.Commun_411_809 |
| Author(s) : Pedicord DL , Flynn MJ , Fanslau C , Miranda M , Hunihan L , Robertson BJ , Pearce BC , Yu XC , Westphal RS , Blat Y |
| Ref : Biochemical & Biophysical Research Communications , 411 :809 , 2011 |
| Abstract : |
| PubMedSearch : Pedicord_2011_Biochem.Biophys.Res.Commun_411_809 |
| PubMedID: 21787747 |
| Title : Improving tolerance of Candida antarctica lipase B towards irreversible thermal inactivation through directed evolution - Zhang_2003_Protein.Eng_16_599 |
| Author(s) : Zhang N , Suen WC , Windsor W , Xiao L , Madison V , Zaks A |
| Ref : Protein Engineering , 16 :599 , 2003 |
| Abstract : |
| PubMedSearch : Zhang_2003_Protein.Eng_16_599 |
| PubMedID: 12968077 |
| Gene_locus related to this paper: canar-LipB |