Indole

Fusion of benzene and pyrazole. Building block for many inhibitors of enzymes. Indole has only one nitrogen atom in position 1 of the pyrazol. Indazol is an analog with nitrogen atoms in position 1 and 2. Benzimidazole, an analog with the nitrogen atoms in positions 1 and 3.
Substrate Main targeted enzyme families Type Structure
HCy-Me BCHE Sulfur Compound Thiophen Indole Fluorescent Probe
Indoleacryloyl-imidazole Carboxypeptidase_S10 Imidazole Indole
Dimethoxy-dioxoisoindol-acetyl-oxyethyl-trimethylazanium BCHE Isoindole Indole Fluorescent Probe Trimethylammonium Ammonium
Ethyl-Indoline-2-carboxylate Hormone-sensitive_lipase_like Indole Alkyl ester
Dihydroprecondylocarpine-acetate Plant_carboxylesterase Indole Alkaloid Natural
Voacangine Hydroxynitrile_lyase Alkaloid Indole Natural
Dehydrosecodine Plant_carboxylesterase Alkaloid Indole Natural
Cannabinoid-PB-22 Carb_B_Chordata Quinoline Indole Cannabinoid-Receptor-ligand
Idalopirdine-rivastigmine BCHE Drug Pro-Drug Indole Carbamate Derivative of Rivastigmine Stigmine Multitarget 5-HT-receptor-ligand
N-acetylserotonin Arylacetamide_deacetylase Derivative of Tryptamine Indole Not AlphaBeta Hydrolase target Natural
3-Acetoxyindole ACHE Carb_B_Chordata Acetate Indole Fluorescent Probe
N-Methylindoxyl-acetate ACHE BCHE Acetate Indole Fluorescent Probe
2-indolinone-3-acetate Acetyl-esterase_deacetylase Acetate Indole
Cotylimide-IV RsbQ-like Cotylimide Strigolactone receptors ligand Sulfur Compound Phthalimido Indole Isoindole Morpholine Sulfonyl
Nijmegen-1 RsbQ-like Cotylimide Strigolactone receptors ligand Isoindole Butenolide Phthalimido
HCy-Me BCHE Sulfur Compound Thiophen Indole Fluorescent Probe
Indoleacryloyl-imidazole Carboxypeptidase_S10 Imidazole Indole
Dimethoxy-dioxoisoindol-acetyl-oxyethyl-trimethylazanium BCHE Isoindole Indole Fluorescent Probe Trimethylammonium Ammonium
Ethyl-Indoline-2-carboxylate Hormone-sensitive_lipase_like Indole Alkyl ester
Dihydroprecondylocarpine-acetate Plant_carboxylesterase Indole Alkaloid Natural
Voacangine Hydroxynitrile_lyase Alkaloid Indole Natural
Dehydrosecodine Plant_carboxylesterase Alkaloid Indole Natural
Cannabinoid-PB-22 Carb_B_Chordata Quinoline Indole Cannabinoid-Receptor-ligand
Idalopirdine-rivastigmine BCHE Drug Pro-Drug Indole Carbamate Derivative of Rivastigmine Stigmine Multitarget 5-HT-receptor-ligand
N-acetylserotonin Arylacetamide_deacetylase Derivative of Tryptamine Indole Not AlphaBeta Hydrolase target Natural
3-Acetoxyindole ACHE Carb_B_Chordata Acetate Indole Fluorescent Probe
N-Methylindoxyl-acetate ACHE BCHE Acetate Indole Fluorescent Probe
2-indolinone-3-acetate Acetyl-esterase_deacetylase Acetate Indole
Cotylimide-IV RsbQ-like Cotylimide Strigolactone receptors ligand Sulfur Compound Phthalimido Indole Isoindole Morpholine Sulfonyl
Nijmegen-1 RsbQ-like Cotylimide Strigolactone receptors ligand Isoindole Butenolide Phthalimido
HCy-Me BCHE Sulfur Compound Thiophen Indole Fluorescent Probe
Indoleacryloyl-imidazole Carboxypeptidase_S10 Imidazole Indole
Dimethoxy-dioxoisoindol-acetyl-oxyethyl-trimethylazanium BCHE Isoindole Indole Fluorescent Probe Trimethylammonium Ammonium
Ethyl-Indoline-2-carboxylate Hormone-sensitive_lipase_like Indole Alkyl ester
Dihydroprecondylocarpine-acetate Plant_carboxylesterase Indole Alkaloid Natural
Voacangine Hydroxynitrile_lyase Alkaloid Indole Natural
Dehydrosecodine Plant_carboxylesterase Alkaloid Indole Natural
Cannabinoid-PB-22 Carb_B_Chordata Quinoline Indole Cannabinoid-Receptor-ligand
Idalopirdine-rivastigmine BCHE Drug Pro-Drug Indole Carbamate Derivative of Rivastigmine Stigmine Multitarget 5-HT-receptor-ligand
N-acetylserotonin Arylacetamide_deacetylase Derivative of Tryptamine Indole Not AlphaBeta Hydrolase target Natural
3-Acetoxyindole ACHE Carb_B_Chordata Acetate Indole Fluorescent Probe
N-Methylindoxyl-acetate ACHE BCHE Acetate Indole Fluorescent Probe
2-indolinone-3-acetate Acetyl-esterase_deacetylase Acetate Indole
Cotylimide-IV RsbQ-like Cotylimide Strigolactone receptors ligand Sulfur Compound Phthalimido Indole Isoindole Morpholine Sulfonyl
Nijmegen-1 RsbQ-like Cotylimide Strigolactone receptors ligand Isoindole Butenolide Phthalimido