Evategrel
General
Type : Not AlphaBeta Hydrolase target, Drug, Pro-Drug, Piperidine, Acetate, Antiplatelet, Sulfur Compound, Organochlorine
Chemical_Nomenclature : (2Z)-2-[(4R)-1-[(1S)-1-(2-chlorophenyl)-2-methoxy-2-oxoethyl]-4-(propan-2-yloxycarbonyloxymethylsulfanyl)piperidin-3-ylidene]acetic acid
Canonical SMILES : CC(C)OC(=O)OCS[C@@H]1CCN(C\/C1=C\/C(=O)O)[C@@H](C2=CC=CC=C2Cl)C(=O)OC
InChI : InChI=1S\/C21H26ClNO7S\/c1-13(2)30-21(27)29-12-31-17-8-9-23(11-14(17)10-18(24)25)19(20(26)28-3)15-6-4-5-7-16(15)22\/h4-7,10,13,17,19H,8-9,11-12H2,1-3H3,(H,24,25)\/b14-10-\/t17-,19+\/m1\/s1
InChIKey : JIHSKBXKKCQDED-DIJKAEOVSA-N
Other name(s) : 9FKJ76ZX22 || orb2695209 || SCHEMBL26301436 || CG-0255 || (Z)-[(4R)-1-[(1S)-1-(2-chlorophenyl)-2-methoxy-2-oxoethyl]-4-{[({[(propan-2-yl)oxy]carbonyl}oxy)methyl]sulfanyl}piperidin-3-ylidene]acetic acid || 1-Methyl (alphaS,3Z,4R)-3-(carboxymethylene)-alpha-(2-chlorophenyl)-4-[[[[(1-methylethoxy)carbonyl]oxy]methyl]thio]-1-piperidineacetate
MW : 472
Formula : C21H26ClNO7S
CAS_number : 2760609-74-1
PubChem : 169069119
UniChem : JIHSKBXKKCQDED-DIJKAEOVSA-N
Target
Structures : No structure
Families : No family
References (6)
| Title : Promising clopidogrel analogs may overcome clopidogrel resistance: 2025 update - Xie_2025_Biochem.Pharmacol__117330 |
| Author(s) : Xie HG , Jiang LP , Tai T , Jia YM , Ji JZ , Mi QY |
| Ref : Biochemical Pharmacology , :117330 , 2025 |
| Abstract : |
| PubMedSearch : Xie_2025_Biochem.Pharmacol__117330 |
| PubMedID: 40953648 |
| Title : Discovery of a novel and potent antiplatelet thiol prodrug CG-0255 - Wu_2025_Eur.J.Med.Chem_297_117973 |
| Author(s) : Wu H , Hou K , Chen X , Tang X , Fan W , Lu C , Zhang Y , Gu Z , He G |
| Ref : Eur Journal of Medicinal Chemistry , 297 :117973 , 2025 |
| Abstract : |
| PubMedSearch : Wu_2025_Eur.J.Med.Chem_297_117973 |
| PubMedID: 40669263 |
| Title : Promising clopidogrel analogs may overcome clopidogrel resistance: 2025 update - Xie_2025_Biochem.Pharmacol__117330 |
| Author(s) : Xie HG , Jiang LP , Tai T , Jia YM , Ji JZ , Mi QY |
| Ref : Biochemical Pharmacology , :117330 , 2025 |
| Abstract : |
| PubMedSearch : Xie_2025_Biochem.Pharmacol__117330 |
| PubMedID: 40953648 |
| Title : Discovery of a novel and potent antiplatelet thiol prodrug CG-0255 - Wu_2025_Eur.J.Med.Chem_297_117973 |
| Author(s) : Wu H , Hou K , Chen X , Tang X , Fan W , Lu C , Zhang Y , Gu Z , He G |
| Ref : Eur Journal of Medicinal Chemistry , 297 :117973 , 2025 |
| Abstract : |
| PubMedSearch : Wu_2025_Eur.J.Med.Chem_297_117973 |
| PubMedID: 40669263 |
| Title : Promising clopidogrel analogs may overcome clopidogrel resistance: 2025 update - Xie_2025_Biochem.Pharmacol__117330 |
| Author(s) : Xie HG , Jiang LP , Tai T , Jia YM , Ji JZ , Mi QY |
| Ref : Biochemical Pharmacology , :117330 , 2025 |
| Abstract : |
| PubMedSearch : Xie_2025_Biochem.Pharmacol__117330 |
| PubMedID: 40953648 |
| Title : Discovery of a novel and potent antiplatelet thiol prodrug CG-0255 - Wu_2025_Eur.J.Med.Chem_297_117973 |
| Author(s) : Wu H , Hou K , Chen X , Tang X , Fan W , Lu C , Zhang Y , Gu Z , He G |
| Ref : Eur Journal of Medicinal Chemistry , 297 :117973 , 2025 |
| Abstract : |
| PubMedSearch : Wu_2025_Eur.J.Med.Chem_297_117973 |
| PubMedID: 40669263 |