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Antiplatelet

Antiplatelet drugs work to make platelets less sticky and thereby help prevent blood clots from forming in arteries. These drugs are not alpha\/beta hydrolases targets bu some are hydrolysed by esterases. Aspirin is an antiplatelet drug. P2Y12 receptor blockers (Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system) are another group of antiplatelet drugs. This group of drugs includes: clopidogrel prasugrel which are substrate of carboxylesterases, and ticlopidine, ticagrelor, and cangrelor which are not
Substrate Main targeted enzyme families Type Structure
Evategrel Not AlphaBeta Hydrolase target Drug Pro-Drug Piperidine Acetate Antiplatelet Sulfur Compound Organochlorine
Prasugrel Carb_B_Chordata Arylacetamide_deacetylase Pancreatic_lipase Drug Not AlphaBeta Hydrolase target Acetate Cyclopropyl Antiplatelet
Vicagrel Arylacetamide_deacetylase Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Pyridine Acetate Antiplatelet Organochlorine
2-oxo-clopidogrel Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Pro-Drug Pyridine Acetate Antiplatelet Organochlorine
Clopidogrel Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Pyridine Antiplatelet Organochlorine
Aspirin BCHE Carb_B_Chordata LYsophospholipase_carboxylesterase Multitarget Cyclooxygenase-2 Inhibitor Salicylic Acetate Benzoate Drug Antiplatelet
Evategrel Not AlphaBeta Hydrolase target Drug Pro-Drug Piperidine Acetate Antiplatelet Sulfur Compound Organochlorine
Prasugrel Carb_B_Chordata Arylacetamide_deacetylase Pancreatic_lipase Drug Not AlphaBeta Hydrolase target Acetate Cyclopropyl Antiplatelet
Vicagrel Arylacetamide_deacetylase Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Pyridine Acetate Antiplatelet Organochlorine
2-oxo-clopidogrel Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Pro-Drug Pyridine Acetate Antiplatelet Organochlorine
Clopidogrel Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Pyridine Antiplatelet Organochlorine
Aspirin BCHE Carb_B_Chordata LYsophospholipase_carboxylesterase Multitarget Cyclooxygenase-2 Inhibitor Salicylic Acetate Benzoate Drug Antiplatelet
Evategrel Not AlphaBeta Hydrolase target Drug Pro-Drug Piperidine Acetate Antiplatelet Sulfur Compound Organochlorine
Prasugrel Carb_B_Chordata Arylacetamide_deacetylase Pancreatic_lipase Drug Not AlphaBeta Hydrolase target Acetate Cyclopropyl Antiplatelet
Vicagrel Arylacetamide_deacetylase Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Pyridine Acetate Antiplatelet Organochlorine
2-oxo-clopidogrel Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Pro-Drug Pyridine Acetate Antiplatelet Organochlorine
Clopidogrel Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Pyridine Antiplatelet Organochlorine
Aspirin BCHE Carb_B_Chordata LYsophospholipase_carboxylesterase Multitarget Cyclooxygenase-2 Inhibitor Salicylic Acetate Benzoate Drug Antiplatelet