FPD5
Not a substrate but an activator. Activating Esterase D by PFD5 exerts antiviral effect through inhibiting glutathionization of LAMP1 during Senecavirus A infection
General
Chemical_Nomenclature : 4-chloro-2-(3-phenyl-2-pyridin-2-yl-3,4-dihydropyrazol-5-yl)phenol
Canonical SMILES : C1C(N(N=C1C2=C(C=CC(=C2)Cl)O)C3=CC=CC=N3)C4=CC=CC=C4
InChI : InChI=1S\/C20H16ClN3O\/c21-15-9-10-19(25)16(12-15)17-13-18(14-6-2-1-3-7-14)24(23-17)20-8-4-5-11-22-20\/h1-12,18,25H,13H2
InChIKey : BZSODIWLTBNDQE-UHFFFAOYSA-N
Other name(s) : CHEMBL4635246 || BDBM50543567
MW : 349.8
Formula : C20H16ClN3O
CAS_number :
PubChem : 136912371
UniChem : BZSODIWLTBNDQE-UHFFFAOYSA-N
Target
Structures : No structure
Families : No family
References (4)
| Title : Activating Esterase D by PFD5 exerts antiviral effect through inhibiting glutathionization of LAMP1 during Senecavirus A infection - Wang_2024_Microb.Pathog_198_107148 |
| Author(s) : Wang S , Han W , Zhao B , Miao J , Lin Z |
| Ref : Microb Pathog , 198 :107148 , 2024 |
| Abstract : |
| PubMedSearch : Wang_2024_Microb.Pathog_198_107148 |
| PubMedID: 39603569 |
| Gene_locus related to this paper: human-ESD |
| Title : Activation of Esterase D by FPD5 Inhibits Growth of A549 Lung Cancer Cells via JAB1\/p53 Pathway - Yao_2022_Genes.(Basel)_13_786 |
| Author(s) : Yao W , Yang Y , Chen X , Cui X , Zhou B , Zhao B , Lin Z , Miao J |
| Ref : Genes (Basel) , 13 :786 , 2022 |
| Abstract : |
| PubMedSearch : Yao_2022_Genes.(Basel)_13_786 |
| PubMedID: 35627173 |
| Gene_locus related to this paper: human-ESD |
| Title : A new activator of esterase D decreases blood cholesterol level through ESD\/JAB1\/ABCA1 pathway - Chen_2021_J.Cell.Physiol_236_4750 |
| Author(s) : Chen X , Su L , Yang Y , Qv J , Wei T , Cui X , Shao J , Liu S , Xu Z , Zhao B , Miao J |
| Ref : Journal of Cellular Physiology , 236 :4750 , 2021 |
| Abstract : |
| PubMedSearch : Chen_2021_J.Cell.Physiol_236_4750 |
| PubMedID: 33615471 |
| Gene_locus related to this paper: human-ESD |
| Title : Finding the mechanism of esterase D activation by a small molecule - Chen_2020_Bioorg.Med.Chem.Lett_30_127150 |
| Author(s) : Chen X , Yang Y , Su L , Cui X , Shao J , Liu S , Zhao B , Miao J |
| Ref : Bioorganic & Medicinal Chemistry Lett , 30 :127150 , 2020 |
| Abstract : |
| PubMedSearch : Chen_2020_Bioorg.Med.Chem.Lett_30_127150 |
| PubMedID: 32247735 |
| Gene_locus related to this paper: human-ESD |