human-ESD
Homo sapiens (Human) esterase D (EC 3.1.1.1) formylglutathione hydrolase
Comment
Q9BVJ2 (Homo sapiens (Human) similar to esterase 10) one aa different from P10768 || Human esterase D (hEstD),1 also called S-formylglutathione hydrolase (SFGH, EC 3.1.2.12), is a ubiquitous intracellular carboxylesterase (CE). hEstD can be found in blood cells and most human tissues and is one of the major CE activities detectable in cytosolic fractions of human liver. SFGH hydrolyzes a range of uncharged ester substrates in vitro, including p-nitrophenyl acetate (pNPA) and 4-methylumbelliferyl acetate. EstD is a thioesterase involved in the removal of genotoxic formaldehyde via a glutathione-dependent reaction. The enzyme may also play a role in xenobiotic metabolism. EstD can be induced in human cells by exposure to methylmethane sulfonate or phenobarbital. FDP5 a novel small-molecule ESD activator enhancing thioesterase activity, reducing glutathionylation cysteine 375 in the lysosomal membrane protein-1 (LAMP1) (Wang et al. 2024)
Relationship
Family : A85-EsteraseD-FGH
Block : X
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMolecular evidence
Sequence
Peptide
MALKQISSNK CFGGLQKVFE HDSVELNCKM KFAVYLPPKA ETGKCPALYW LSGLTCTEQN FISKSGYHQS ASEHGLVVIA PDTSPRGCNI KGEDESWDFG TGAGFYVDAT EDPWKTNYRM YSYVTEELPQ LINANFPVDP QRMSIFGHSM GGHGALICAL KNPGKYKSVS AFAPICNPVL CPWGKKAFSG YLGTDQSKWK AYDATHLVKS YPGSQLDILI DQGKDDQFLL DGQLLPDNFI AACTEKKIPV VFRLQEGYDH SYYFIATFIT DHIRHHAKYL NA
References (14)
| Title : Activating Esterase D by PFD5 exerts antiviral effect through inhibiting glutathionization of LAMP1 during Senecavirus A infection - Wang_2024_Microb.Pathog_198_107148 |
| Author(s) : Wang S , Han W , Zhao B , Miao J , Lin Z |
| Ref : Microb Pathog , 198 :107148 , 2024 |
| Abstract : |
| PubMedSearch : Wang_2024_Microb.Pathog_198_107148 |
| PubMedID: 39603569 |
| Gene_locus related to this paper: human-ESD |
| Title : Esterase D interacts with metallothionein 2A and inhibits the migration of A549 lung cancer cells in vitro - Yao_2023_J.Cell.Biochem__ |
| Author(s) : Yao W , Chen X , Cui X , Zhou B , Zhao B , Lin Z , Miao J |
| Ref : Journal of Cellular Biochemistry , : , 2023 |
| Abstract : |
| PubMedSearch : Yao_2023_J.Cell.Biochem__ |
| PubMedID: 36649442 |
| Gene_locus related to this paper: human-ESD |
| Title : Activation of Esterase D by FPD5 Inhibits Growth of A549 Lung Cancer Cells via JAB1\/p53 Pathway - Yao_2022_Genes.(Basel)_13_786 |
| Author(s) : Yao W , Yang Y , Chen X , Cui X , Zhou B , Zhao B , Lin Z , Miao J |
| Ref : Genes (Basel) , 13 :786 , 2022 |
| Abstract : |
| PubMedSearch : Yao_2022_Genes.(Basel)_13_786 |
| PubMedID: 35627173 |
| Gene_locus related to this paper: human-ESD |
| Title : Esterase D stabilizes FKBP25 to suppress mTORC1 - Yang_2021_Cell.Mol.Biol.Lett_26_50 |
| Author(s) : Yang Y , Chen X , Yao W , Cui X , Li N , Lin Z , Zhao B , Miao J |
| Ref : Cellular & Molecular Biology Lett , 26 :50 , 2021 |
| Abstract : |
| PubMedSearch : Yang_2021_Cell.Mol.Biol.Lett_26_50 |
| PubMedID: 34875997 |
| Gene_locus related to this paper: human-ESD |
| Title : A new activator of esterase D decreases blood cholesterol level through ESD\/JAB1\/ABCA1 pathway - Chen_2021_J.Cell.Physiol_236_4750 |
| Author(s) : Chen X , Su L , Yang Y , Qv J , Wei T , Cui X , Shao J , Liu S , Xu Z , Zhao B , Miao J |
| Ref : Journal of Cellular Physiology , 236 :4750 , 2021 |
| Abstract : |
| PubMedSearch : Chen_2021_J.Cell.Physiol_236_4750 |
| PubMedID: 33615471 |
| Gene_locus related to this paper: human-ESD |
| Title : Finding the mechanism of esterase D activation by a small molecule - Chen_2020_Bioorg.Med.Chem.Lett_30_127150 |
| Author(s) : Chen X , Yang Y , Su L , Cui X , Shao J , Liu S , Zhao B , Miao J |
| Ref : Bioorganic & Medicinal Chemistry Lett , 30 :127150 , 2020 |
| Abstract : |
| PubMedSearch : Chen_2020_Bioorg.Med.Chem.Lett_30_127150 |
| PubMedID: 32247735 |
| Gene_locus related to this paper: human-ESD |
| Title : Crystal structure of human esterase D: a potential genetic marker of retinoblastoma - Wu_2009_FASEB.J_23_1441 |
| Author(s) : Wu D , Li Y , Song G , Zhang D , Shaw N , Liu ZJ |
| Ref : FASEB Journal , 23 :1441 , 2009 |
| Abstract : |
| PubMedSearch : Wu_2009_FASEB.J_23_1441 |
| PubMedID: 19126594 |
| Gene_locus related to this paper: human-ESD |
| Title : Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population - Saito_2003_J.Hum.Genet_48_249 |
| Author(s) : Saito S , Iida A , Sekine A , Kawauchi S , Higuchi S , Ogawa C , Nakamura Y |
| Ref : J Hum Genet , 48 :249 , 2003 |
| Abstract : |
| PubMedSearch : Saito_2003_J.Hum.Genet_48_249 |
| PubMedID: 12721789 |
| Gene_locus related to this paper: human-CES2 , human-ESD |
| Title : Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning - Hu_2000_Proc.Natl.Acad.Sci.U.S.A_97_9543 |
| Author(s) : Hu RM , Han ZG , Song HD , Peng YD , Huang QH , Ren SX , Gu YJ , Huang CH , Li YB , Jiang CL , Fu G , Zhang QH , Gu BW , Dai M , Mao YF , Gao GF , Rong R , Ye M , Zhou J , Xu SH , Gu J , Shi JX , Jin WR , Zhang CK , Wu TM , Huang GY , Chen Z , Chen MD , Chen JL |
| Ref : Proc Natl Acad Sci U S A , 97 :9543 , 2000 |
| Abstract : |
| PubMedSearch : Hu_2000_Proc.Natl.Acad.Sci.U.S.A_97_9543 |
| PubMedID: 10931946 |
| Gene_locus related to this paper: human-ESD |
| Title : Molecular analysis of esterase D polymorphism - Tsuchida_1994_Hum.Genet_93_255 |
| Author(s) : Tsuchida S , Fukui E , Ikemoto S |
| Ref : Hum Genet , 93 :255 , 1994 |
| Abstract : |
| PubMedSearch : Tsuchida_1994_Hum.Genet_93_255 |
| PubMedID: 7907313 |
| Gene_locus related to this paper: human-ESD |
| Title : Human esterase D gene: complete cDNA sequence, genomic structure, and application in the genetic diagnosis of human retinoblastoma - Young_1988_Hum.Genet_79_137 |
| Author(s) : Young LJ , Lee EY , To HA , Bookstein R , Shew JY , Donoso LA , Sery T , Giblin M , Shields JA , Lee WH |
| Ref : Hum Genet , 79 :137 , 1988 |
| Abstract : |
| PubMedSearch : Young_1988_Hum.Genet_79_137 |
| PubMedID: 3164702 |
| Gene_locus related to this paper: human-ESD |
| Title : Molecular cloning of the human esterase D gene, a genetic marker of retinoblastoma - Lee_1986_Proc.Natl.Acad.Sci.U.S.A_83_6337 |
| Author(s) : Lee EY , Lee WH |
| Ref : Proc Natl Acad Sci U S A , 83 :6337 , 1986 |
| Abstract : |
| PubMedSearch : Lee_1986_Proc.Natl.Acad.Sci.U.S.A_83_6337 |
| PubMedID: 3462698 |
| Gene_locus related to this paper: human-ESD |
| Title : Cloning of the esterase D gene: a polymorphic gene probe closely linked to the retinoblastoma locus on chromosome 13 - Squire_1986_Proc.Natl.Acad.Sci.U.S.A_83_6573 |
| Author(s) : Squire J , Dryja TP , Dunn J , Goddard A , Hofmann T , Musarella M , Willard HF , Becker AJ , Gallie BL , Phillips RA |
| Ref : Proc Natl Acad Sci U S A , 83 :6573 , 1986 |
| Abstract : |
| PubMedSearch : Squire_1986_Proc.Natl.Acad.Sci.U.S.A_83_6573 |
| PubMedID: 3462714 |
| Gene_locus related to this paper: human-ESD |