Fluorescein-di(diethylphosphate)
A fluorogenic substrate for detection of organophosphatase activity
General
Type : Fluorescent Probe, Benzofuran, Organophosphate, Flu-OP, Derivative of Paraoxon, Xanthene
Chemical_Nomenclature :
Canonical SMILES : CCOP(=O)(OCC)OC1=CC2=C(C=C1)C3(C4=C(O2)C=C(C=C4)OP(=O)(OCC)OCC)C5=CC=CC=C5C(=O)O3
InChI : InChI=1S\/C28H30O11P2\/c1-5-32-40(30,33-6-2)38-19-13-15-23-25(17-19)36-26-18-20(39-41(31,34-7-3)35-8-4)14-16-24(26)28(23)22-12-10-9-11-21(22)27(29)37-28\/h9-18H,5-8H2,1-4H3
InChIKey : XTQFRHYOPAKUAK-UHFFFAOYSA-N
Other name(s) : FDDEP || Tetraethyl (3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl) bis(phosphate) || (6'-diethoxyphosphoryloxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl) diethyl phosphate
MW : 604.5
Formula : C28H30O11P2
CAS_number :
PubChem : 11467555
UniChem : XTQFRHYOPAKUAK-UHFFFAOYSA-N
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Target
Structures : No structure
Families : Dienelactone_hydrolase
References (4)
| Title : Ultrahigh-throughput directed evolution of a metal-free alpha\/beta-hydrolase with a Cys-His-Asp triad into an efficient phosphotriesterase - Schnettler-Fernandez_2022_Biorxiv__ |
| Author(s) : Schnettler-Fernandez D , Klein OJ , Kaminski TS , Colin PY , Hollfelder F |
| Ref : Biorxiv , : , 2022 |
| Abstract : |
| PubMedSearch : Schnettler-Fernandez_2022_Biorxiv__ |
| PubMedID: |
| Gene_locus related to this paper: 9bact-KP212148 |
| Title : Ultrahigh-Throughput Directed Evolution of a Metal-Free alpha\/beta-Hydrolase with a Cys-His-Asp Triad into an Efficient Phosphotriesterase - Schnettler_2022_J.Am.Chem.Soc__ |
| Author(s) : Schnettler JD , Klein OJ , Kaminski TS , Colin PY , Hollfelder F |
| Ref : Journal of the American Chemical Society , : , 2022 |
| Abstract : |
| PubMedSearch : Schnettler_2022_J.Am.Chem.Soc__ |
| PubMedID: 36583539 |
| Gene_locus related to this paper: 9bact-KP212148 |
| Title : Evolution of enzyme catalysts caged in biomimetic gel-shell beads - Fischlechner_2014_Nat.Chem_6_791 |
| Author(s) : Fischlechner M , Schaerli Y , Mohamed MF , Patil S , Abell C , Hollfelder F |
| Ref : Nat Chem , 6 :791 , 2014 |
| Abstract : |
| PubMedSearch : Fischlechner_2014_Nat.Chem_6_791 |
| PubMedID: 25143214 |
| Title : A fluorogenic substrate for detection of organophosphatase activity - Soukharev_2004_Anal.Biochem_327_140 |
| Author(s) : Soukharev S , Hammond DJ |
| Ref : Analytical Biochemistry , 327 :140 , 2004 |
| Abstract : |
| PubMedSearch : Soukharev_2004_Anal.Biochem_327_140 |
| PubMedID: 15033522 |