Organophosphate

Many inhibitors are in fact substrates very slowly hydrolyzed. Organophosphates (also known as phosphate esters OP) are a class of organophosphorus compounds with the general structure O=P(OR)3. They can be considered as esters of phosphoric acid. Here we consider only those compounds that interact with alpha\/beta hydrolases mostly as inhibitors (insecticides, nerve agents etc...). As the number of compounds increases in the database you can choose to select subsets such as: Chemical Warfare Agent<\/A> (CWA) or more precisely: Nerve Agent G-series<\/A>, Nerve Agent V-series<\/A>, Novichok<\/A>, Derivative of Sarin<\/A>, Derivative of Soman<\/A>, Surrogate OP<\/A>, Organothiophosphate<\/A>, Phosphonylatedoxime<\/A>, or pesticides (including compounds not OP): Herbicide<\/A>, Insecticide<\/A>, Anthelmintic<\/A>, or investigational compounds: Cyclic OP<\/A>, ABPP-Probe<\/A>, Flu-OP<\/A>. You can also search another category of compounds in the list: Types of inhibitors<\/A>
Substrate Main targeted enzyme families Type Structure
Fosinopril Plasmodium_subtelomeric_PST-A Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Pro-Drug Pyrrolidine Angiotensin-converting enzyme inhibitor Organophosphate
Fluorescein-di(diethylphosphate) Dienelactone_hydrolase Fluorescent Probe Benzofuran Organophosphate Flu-OP Derivative of Paraoxon Xanthene
DEPFMU Fluorescent Probe Organophosphate Flu-OP Coumarin Chromen
DMAP Organophosphate
P-nitrophenyl-phosphate ACPH_Peptidase_S9 Organophosphate pNP Chromogen
Chlorpyrifos Est9X Duf_3089 Trichloro Insecticide Organophosphate Sulfur Compound Organothiophosphate OPIDN-OP Organochlorine
Chlorpyrifos-oxon Arylacetamide_deacetylase Hormone-sensitive_lipase_like Trichloro Insecticide Organophosphate Organochlorine
dMUP Carb_B_Arthropoda Organophosphate Coumarin Chromen
Methyl-DEUP Carb_B_Arthropoda Organophosphate Coumarin Chromen
DEUP Carb_B_Arthropoda Hormone-sensitive_lipase_like Arylacetamide_deacetylase Organophosphate Coumarin Chromen
Malathion Insecticide Acaricide Organophosphate Sulfur Compound Organothiophosphate
Paraoxon BCHE Dienelactone_hydrolase Organophosphate Insecticide Derivative of Paraoxon pNP
Fosinopril Plasmodium_subtelomeric_PST-A Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Pro-Drug Pyrrolidine Angiotensin-converting enzyme inhibitor Organophosphate
Fluorescein-di(diethylphosphate) Dienelactone_hydrolase Fluorescent Probe Benzofuran Organophosphate Flu-OP Derivative of Paraoxon Xanthene
DEPFMU Fluorescent Probe Organophosphate Flu-OP Coumarin Chromen
DMAP Organophosphate
P-nitrophenyl-phosphate ACPH_Peptidase_S9 Organophosphate pNP Chromogen
Chlorpyrifos Est9X Duf_3089 Trichloro Insecticide Organophosphate Sulfur Compound Organothiophosphate OPIDN-OP Organochlorine
Chlorpyrifos-oxon Arylacetamide_deacetylase Hormone-sensitive_lipase_like Trichloro Insecticide Organophosphate Organochlorine
dMUP Carb_B_Arthropoda Organophosphate Coumarin Chromen
Methyl-DEUP Carb_B_Arthropoda Organophosphate Coumarin Chromen
DEUP Carb_B_Arthropoda Hormone-sensitive_lipase_like Arylacetamide_deacetylase Organophosphate Coumarin Chromen
Malathion Insecticide Acaricide Organophosphate Sulfur Compound Organothiophosphate
Paraoxon BCHE Dienelactone_hydrolase Organophosphate Insecticide Derivative of Paraoxon pNP
Fosinopril Plasmodium_subtelomeric_PST-A Carb_B_Chordata Not AlphaBeta Hydrolase target Drug Pro-Drug Pyrrolidine Angiotensin-converting enzyme inhibitor Organophosphate
Fluorescein-di(diethylphosphate) Dienelactone_hydrolase Fluorescent Probe Benzofuran Organophosphate Flu-OP Derivative of Paraoxon Xanthene
DEPFMU Fluorescent Probe Organophosphate Flu-OP Coumarin Chromen
DMAP Organophosphate
P-nitrophenyl-phosphate ACPH_Peptidase_S9 Organophosphate pNP Chromogen
Chlorpyrifos Est9X Duf_3089 Trichloro Insecticide Organophosphate Sulfur Compound Organothiophosphate OPIDN-OP Organochlorine
Chlorpyrifos-oxon Arylacetamide_deacetylase Hormone-sensitive_lipase_like Trichloro Insecticide Organophosphate Organochlorine
dMUP Carb_B_Arthropoda Organophosphate Coumarin Chromen
Methyl-DEUP Carb_B_Arthropoda Organophosphate Coumarin Chromen
DEUP Carb_B_Arthropoda Hormone-sensitive_lipase_like Arylacetamide_deacetylase Organophosphate Coumarin Chromen
Malathion Insecticide Acaricide Organophosphate Sulfur Compound Organothiophosphate
Paraoxon BCHE Dienelactone_hydrolase Organophosphate Insecticide Derivative of Paraoxon pNP