Dienelactone_hydrolase
Relationship
Comment
Dienelactone hydrolases play a crucial role in chlorocatechol degradation via the modified ortho cleavage pathway. Enzymes induced in 4-fluorobenzoate-utilizing bacteria have been classified into three groups on the basis of their specificity towards cis- and trans-dienelactone. The catalytic triad of the prototype psepu-clcd1 consists of Cys123, His202 and Asp171
Database
Interpro : IPR002925 Dienelactone hydrolase
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF01738 DLH
Prints : No Print
EC Number : 3.1.1.45
Structures (23)
Genes Proteins in Dienelactone_hydrolase family (431)
Fragments of genes in Dienelactone_hydrolase family (15)
Structures in Dienelactone_hydrolase family (23)Substrates in Dienelactone_hydrolase family (3)
Inhibitors in Dienelactone_hydrolase family (2)
References (11)
| Title : Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics - Colin_2015_Nat.Commun_6_10008 |
| Author(s) : Colin PY , Kintses B , Gielen F , Miton CM , Fischer G , Mohamed MF , Hyvonen M , Morgavi DP , Janssen DB , Hollfelder F |
| Ref : Nat Commun , 6 :10008 , 2015 |
| Abstract : Colin_2015_Nat.Commun_6_10008 |
| ESTHER : Colin_2015_Nat.Commun_6_10008 |
| PubMedSearch : Colin_2015_Nat.Commun_6_10008 |
| PubMedID: 26639611 |
| Gene_locus related to this paper: 9bact-KP212148 |
| Title : Directed evolution of new and improved enzyme functions using an evolutionary intermediate and multidirectional search - Porter_2015_ACS.Chem.Biol_10_611 |
| Author(s) : Porter JL , Boon PL , Murray TP , Huber T , Collyer CA , Ollis DL |
| Ref : ACS Chemical Biology , 10 :611 , 2015 |
| Abstract : Porter_2015_ACS.Chem.Biol_10_611 |
| ESTHER : Porter_2015_ACS.Chem.Biol_10_611 |
| PubMedSearch : Porter_2015_ACS.Chem.Biol_10_611 |
| PubMedID: 25419863 |
| Gene_locus related to this paper: psepu-clcd1 |
| Title : Crystallization of dienelactone hydrolase in two space groups: structural changes caused by crystal packing - Porter_2014_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_70_884 |
| Author(s) : Porter JL , Carr PD , Collyer CA , Ollis DL |
| Ref : Acta Crystallographica F Struct Biol Commun , 70 :884 , 2014 |
| Abstract : Porter_2014_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_70_884 |
| ESTHER : Porter_2014_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_70_884 |
| PubMedSearch : Porter_2014_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_70_884 |
| PubMedID: 25005082 |
| Gene_locus related to this paper: psepu-clcd1 |
| Title : Following directed evolution with crystallography: structural changes observed in changing the substrate specificity of dienelactone hydrolase - Kim_2005_Acta.Crystallogr.D.Biol.Crystallogr_61_920 |
| Author(s) : Kim HK , Liu JW , Carr PD , Ollis DL |
| Ref : Acta Crystallographica D Biol Crystallogr , 61 :920 , 2005 |
| Abstract : Kim_2005_Acta.Crystallogr.D.Biol.Crystallogr_61_920 |
| ESTHER : Kim_2005_Acta.Crystallogr.D.Biol.Crystallogr_61_920 |
| PubMedSearch : Kim_2005_Acta.Crystallogr.D.Biol.Crystallogr_61_920 |
| PubMedID: 15983415 |
| Gene_locus related to this paper: psepu-clcd1 |
| Title : Monitoring key reactions in degradation of chloroaromatics by in situ (1)H nuclear magnetic resonance: solution structures of metabolites formed from cis-dienelactone - Pieper_2002_J.Bacteriol_184_1466 |
| Author(s) : Pieper DH , Pollmann K , Nikodem P , Gonzalez B , Wray V |
| Ref : Journal of Bacteriology , 184 :1466 , 2002 |
| Abstract : Pieper_2002_J.Bacteriol_184_1466 |
| ESTHER : Pieper_2002_J.Bacteriol_184_1466 |
| PubMedSearch : Pieper_2002_J.Bacteriol_184_1466 |
| PubMedID: 11844781 |
| Title : Structure of the C123S mutant of dienelactone hydrolase (DLH) bound with the PMS moiety of the protease inhibitor phenylmethylsulfonyl fluoride (PMSF) - Robinson_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1376 |
| Author(s) : Robinson A , Edwards KJ , Carr PD , Barton JD , Ewart GD , Ollis DL |
| Ref : Acta Crystallographica D Biol Crystallogr , 56 :1376 , 2000 |
| Abstract : Robinson_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1376 |
| ESTHER : Robinson_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1376 |
| PubMedSearch : Robinson_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1376 |
| PubMedID: 11053834 |
| Gene_locus related to this paper: psepu-clcd1 |
| Title : Evolution of chlorocatechol catabolic pathways. Conclusions to be drawn from comparisons of lactone hydrolases - Schlomann_1994_Biodegradation_5_301 |
| Author(s) : Schlomann M |
| Ref : Biodegradation , 5 :301 , 1994 |
| Abstract : Schlomann_1994_Biodegradation_5_301 |
| ESTHER : Schlomann_1994_Biodegradation_5_301 |
| PubMedSearch : Schlomann_1994_Biodegradation_5_301 |
| PubMedID: 7765840 |
| Title : Substrate-induced activation of dienelactone hydrolase: an enzyme with a naturally occurring Cys-His-Asp triad - Cheah_1993_Protein.Eng_6_575 |
| Author(s) : Cheah E , Austin C , Ashley GW , Ollis D |
| Ref : Protein Engineering , 6 :575 , 1993 |
| Abstract : Cheah_1993_Protein.Eng_6_575 |
| ESTHER : Cheah_1993_Protein.Eng_6_575 |
| PubMedSearch : Cheah_1993_Protein.Eng_6_575 |
| PubMedID: 8234228 |
| Gene_locus related to this paper: psepu-clcd1 |
| Title : Catalysis by dienelactone hydrolase: a variation on the protease mechanism - Cheah_1993_Proteins_16_64 |
| Author(s) : Cheah E , Ashley GW , Gary J , Ollis D |
| Ref : Proteins , 16 :64 , 1993 |
| Abstract : Cheah_1993_Proteins_16_64 |
| ESTHER : Cheah_1993_Proteins_16_64 |
| PubMedSearch : Cheah_1993_Proteins_16_64 |
| PubMedID: 8497485 |
| Gene_locus related to this paper: psepu-clcd1 |
| Title : Refined structure of dienelactone hydrolase at 1.8 A - Pathak_1990_J.Mol.Biol_214_497 |
| Author(s) : Pathak D , Ollis D |
| Ref : Journal of Molecular Biology , 214 :497 , 1990 |
| Abstract : Pathak_1990_J.Mol.Biol_214_497 |
| ESTHER : Pathak_1990_J.Mol.Biol_214_497 |
| PubMedSearch : Pathak_1990_J.Mol.Biol_214_497 |
| PubMedID: 2380986 |
| Gene_locus related to this paper: psepu-clcd1 |
| Title : X-ray crystallographic structure of dienelactone hydrolase at 2.8 A - Pathak_1988_J.Mol.Biol_204_435 |
| Author(s) : Pathak D , Ngai KL , Ollis D |
| Ref : Journal of Molecular Biology , 204 :435 , 1988 |
| Abstract : Pathak_1988_J.Mol.Biol_204_435 |
| ESTHER : Pathak_1988_J.Mol.Biol_204_435 |
| PubMedSearch : Pathak_1988_J.Mol.Biol_204_435 |
| PubMedID: 3221394 |
| Gene_locus related to this paper: psepu-clcd1 |