Glutathione
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides. psesp-llipa lipase-activation-factor (LAF) (reduced form of glutathione) for formation of intermolecular disulfide bound. Product of hydrolysis of S-formylglutathione by S-formylglutathione hydrolase (Family A85-EsteraseD-FGH)
General
Type : Peptide
Chemical_Nomenclature : (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid
Canonical SMILES : C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N
InChI : InChI=1S\/C10H17N3O6S\/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16\/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)\/t5-,6-\/m0\/s1
InChIKey : RWSXRVCMGQZWBV-WDSKDSINSA-N
Other name(s) : L-Glutathione || Glutathion || Isethion || GSH || N-(N-L-gamma-Glutamyl-L-cysteinyl)glycine || L-glutamyl-L-cysteinylglycine || CHEBI:16856 || [Glu(-Cys)]n-Gly || H-gammaGlu-Cys-Gly-OH || H-gGlu-Cys-Gly-OH || L-gamma-glutamyl-L-cysteinyl-glycine
MW : 307.33
Formula : C10H17N3O6S
CAS_number : 70-18-8
PubChem : 124886
UniChem : RWSXRVCMGQZWBV-WDSKDSINSA-N
Target
Structures : No structure
Families : Bacterial_lip_FamI.1
References (6)
| Title : AChE activity self-breathing control mechanisms regulated by H(2)S(n) and GSH: Persulfidation and glutathionylation on sulfhydryl after disulfide bonds cleavage - Zhu_2024_Int.J.Biol.Macromol_259_129117 |
| Author(s) : Zhu Y , Hu Z , Liu Y , Yan T , Liu L , Wang Y , Bai B |
| Ref : Int J Biol Macromol , 259 :129117 , 2024 |
| Abstract : |
| PubMedSearch : Zhu_2024_Int.J.Biol.Macromol_259_129117 |
| PubMedID: 38211930 |
| Title : AChE activity self-breathing control mechanisms regulated by H(2)S(n) and GSH: Persulfidation and glutathionylation on sulfhydryl after disulfide bonds cleavage - Zhu_2024_Int.J.Biol.Macromol_259_129117 |
| Author(s) : Zhu Y , Hu Z , Liu Y , Yan T , Liu L , Wang Y , Bai B |
| Ref : Int J Biol Macromol , 259 :129117 , 2024 |
| Abstract : |
| PubMedSearch : Zhu_2024_Int.J.Biol.Macromol_259_129117 |
| PubMedID: 38211930 |
| Title : AChE activity self-breathing control mechanisms regulated by H(2)S(n) and GSH: Persulfidation and glutathionylation on sulfhydryl after disulfide bonds cleavage - Zhu_2024_Int.J.Biol.Macromol_259_129117 |
| Author(s) : Zhu Y , Hu Z , Liu Y , Yan T , Liu L , Wang Y , Bai B |
| Ref : Int J Biol Macromol , 259 :129117 , 2024 |
| Abstract : |
| PubMedSearch : Zhu_2024_Int.J.Biol.Macromol_259_129117 |
| PubMedID: 38211930 |
| Title : Glutathione as an essential factor for chaperon-mediated activation of lactonizing lipase (LipL) from Pseudomonas sp. 109 - Tanaka_2000_J.Biochem_127_597 |
| Author(s) : Tanaka J , Nihira T , Yamada Y |
| Ref : J Biochem , 127 :597 , 2000 |
| Abstract : |
| PubMedSearch : Tanaka_2000_J.Biochem_127_597 |
| PubMedID: 10739951 |
| Gene_locus related to this paper: psesp-llipa |
| Title : Glutathione as an essential factor for chaperon-mediated activation of lactonizing lipase (LipL) from Pseudomonas sp. 109 - Tanaka_2000_J.Biochem_127_597 |
| Author(s) : Tanaka J , Nihira T , Yamada Y |
| Ref : J Biochem , 127 :597 , 2000 |
| Abstract : |
| PubMedSearch : Tanaka_2000_J.Biochem_127_597 |
| PubMedID: 10739951 |
| Gene_locus related to this paper: psesp-llipa |
| Title : Glutathione as an essential factor for chaperon-mediated activation of lactonizing lipase (LipL) from Pseudomonas sp. 109 - Tanaka_2000_J.Biochem_127_597 |
| Author(s) : Tanaka J , Nihira T , Yamada Y |
| Ref : J Biochem , 127 :597 , 2000 |
| Abstract : |
| PubMedSearch : Tanaka_2000_J.Biochem_127_597 |
| PubMedID: 10739951 |
| Gene_locus related to this paper: psesp-llipa |