Nap-FY-CPT
Prodrug for anticancer drug camptothecin. Nap-FYp -CPT (Nap-Phe-Phe-Lys(Camptothecin)-Tyr(H2PO3)OH)can be cleaved by phosphatase and converted into its dephosphorylated product Nap-FY-CPT, which then self-assembles to form a fibrous hydrogel. The Nap-FY-CPT is further cleaved by CES to yield active drug Camptothecin (CPT). Nap-FYp-CPT@MSN-CHI consists of chitosan-modified mesoporous silica nanoparticles (MSN-CHI) loaded with the prodrug
General
Type : Drug, Pro-Drug, Derivative of Irinotecan, Not AlphaBeta Hydrolase target, Piperidine, Peptide
Chemical_Nomenclature :
Canonical SMILES : C1=CC=C2C(=C1)C=C4C(=N2)C3=CC5=C(C(N3C4)=O)COC(C5(CC)OC(CCC(NCCCC[C@H](NC([C@@H](NC([C@@H](NC(=O)CC6=CC7=C(C=C6)C=CC=C7)CC8=CC=CC=C8)=O)CC9=CC=CC=C9)=O)C(N[C@H](C(O)=O)CC\%10=CC=C(C=C\%10)O)=O)=O)=O)=O
InChI : InChI=1S\/C69H67N7O13\/c1-2-69(52-39-58-62-49(38-48-21-11-12-22-53(48)72-62)40-76(58)66(84)51(52)41-88-68(69)87)89-61(80)31-30-59(78)70-32-14-13-23-54(63(81)75-57(67(85)86)36-44-25-28-50(77)29-26-44)73-65(83)56(35-43-17-7-4-8-18-43)74-64(82)55(34-42-15-5-3-6-16-42)71-60(79)37-45-24-27-46-19-9-10-20-47(46)33-45\/h3-12,15-22,24-29,33,38-39,54-57,77H,2,13-14,23,30-32,34-37,40-41H2,1H3,(H,70,78)(H,71,79)(H,73,83)(H,74,82)(H,75,81)(H,85,86)\/t54-,55-,56-,57-,69?\/m0\/s1
InChIKey : FIFQVIJUPXPBLB-STRKTETNSA-N
Other name(s) : Nap-Phe-Phe-Lys(Camptothecin)-Tyr
Target
Structures : No structure
Families : No family
References (1)
| Title : Acid and phosphatase-triggered release and trapping of a prodrug on cancer cell enhance its chemotherapy - Zhu_2025_Biomaterials_320_123254 |
| Author(s) : Zhu L , Shen Z , Liu X , Tang R , Zhang Z , Zhao F , Wang J , Zhan W , Zhou L , Liang G , Wang R |
| Ref : Biomaterials , 320 :123254 , 2025 |
| Abstract : |
| PubMedSearch : Zhu_2025_Biomaterials_320_123254 |
| PubMedID: 40088578 |