Suc-GPLGP-AMC
General
Type : Coumarin, Chromen, 7-amido-4-methylcoumarin, Peptide, Pyrrolidine
Chemical_Nomenclature : 4-[[2-[(2S)-2-[[(2S)-4-methyl-1-[[2-[(2S)-2-[(4-methyl-2-oxochromen-7-yl)carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-4-oxobutanoic acid
Canonical SMILES : CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@@H]3CCCN3C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]4CCCN4C(=O)CNC(=O)CCC(=O)O
InChI : InChI=1S\/C34H44N6O10\/c1-19(2)14-23(38-34(49)25-7-5-13-40(25)28(42)17-35-27(41)10-11-30(44)45)32(47)36-18-29(43)39-12-4-6-24(39)33(48)37-21-8-9-22-20(3)15-31(46)50-26(22)16-21\/h8-9,15-16,19,23-25H,4-7,10-14,17-18H2,1-3H3,(H,35,41)(H,36,47)(H,37,48)(H,38,49)(H,44,45)\/t23-,24-,25-\/m0\/s1
InChIKey : RPHBOWQMQBFJME-SDHOMARFSA-N
Other name(s) : Succinylglycyl-prolyl-leucyl-glycyl-prolyl-4-methylcoumaryl-7-amide || Suc-Gly-Pro-Leu-Pro-7-amido-4-methylcoumarin || (succinyl-Gly-Pro-Gly-Pro)-4-methylcoumaryl-7-amide || Suc-Gly-Pro-Leu-Gly-Pro-7-amido-4-methylcoumarin || L-Prolinamide, N-(3-carboxy-1-oxopropyl)glycyl-L-prolyl-L-leucylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- || Suc-GPLGP-MCA || 276-767-2 || Suc-Gly-Pro-Leu-Gly-Pro-MCA || Suc-Gly-Pro-Leu-Gly-Pro-AMC || SCHEMBL29543561
MW : 696.7
Formula : C34H44N6O10
CAS_number : 72698-36-3
PubChem : 126302
UniChem : RPHBOWQMQBFJME-SDHOMARFSA-N
Target
Structures : No structure
Families : S9N_PPCE_Peptidase_S9
References (12)
| Title : Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP - Batra_2025_Nat.Commun_16_7164 |
| Author(s) : Batra S , Olmo F , Ragan TJ , Kaplan M , Calvaresi V , Frank AM , Lancey C , Assadipapari M , Ying C , Struwe WB , Hesketh EL , Kelly JM , Barfod L , Campeotto I |
| Ref : Nat Commun , 16 :7164 , 2025 |
| Abstract : |
| PubMedSearch : Batra_2025_Nat.Commun_16_7164 |
| PubMedID: 40764299 |
| Gene_locus related to this paper: tryb2-q6ha27 , trycr-TCPO |
| Title : Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP - Batra_2025_Nat.Commun_16_7164 |
| Author(s) : Batra S , Olmo F , Ragan TJ , Kaplan M , Calvaresi V , Frank AM , Lancey C , Assadipapari M , Ying C , Struwe WB , Hesketh EL , Kelly JM , Barfod L , Campeotto I |
| Ref : Nat Commun , 16 :7164 , 2025 |
| Abstract : |
| PubMedSearch : Batra_2025_Nat.Commun_16_7164 |
| PubMedID: 40764299 |
| Gene_locus related to this paper: tryb2-q6ha27 , trycr-TCPO |
| Title : Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP - Batra_2025_Nat.Commun_16_7164 |
| Author(s) : Batra S , Olmo F , Ragan TJ , Kaplan M , Calvaresi V , Frank AM , Lancey C , Assadipapari M , Ying C , Struwe WB , Hesketh EL , Kelly JM , Barfod L , Campeotto I |
| Ref : Nat Commun , 16 :7164 , 2025 |
| Abstract : |
| PubMedSearch : Batra_2025_Nat.Commun_16_7164 |
| PubMedID: 40764299 |
| Gene_locus related to this paper: tryb2-q6ha27 , trycr-TCPO |
| Title : Mycobacterium tuberculosis Prolyl Oligopeptidase Induces In vitro Secretion of Proinflammatory Cytokines by Peritoneal Macrophages - Portugal_2017_Front.Microbiol_8_155 |
| Author(s) : Portugal B , Motta FN , Correa AF , Nolasco DO , De Almeida H , Magalhaes KG , Atta AL , Vieira FD , Bastos IM , Santana JM |
| Ref : Front Microbiol , 8 :155 , 2017 |
| Abstract : |
| PubMedSearch : Portugal_2017_Front.Microbiol_8_155 |
| PubMedID: 28223969 |
| Gene_locus related to this paper: myctu-RV0457C |
| Title : Mycobacterium tuberculosis Prolyl Oligopeptidase Induces In vitro Secretion of Proinflammatory Cytokines by Peritoneal Macrophages - Portugal_2017_Front.Microbiol_8_155 |
| Author(s) : Portugal B , Motta FN , Correa AF , Nolasco DO , De Almeida H , Magalhaes KG , Atta AL , Vieira FD , Bastos IM , Santana JM |
| Ref : Front Microbiol , 8 :155 , 2017 |
| Abstract : |
| PubMedSearch : Portugal_2017_Front.Microbiol_8_155 |
| PubMedID: 28223969 |
| Gene_locus related to this paper: myctu-RV0457C |
| Title : Mycobacterium tuberculosis Prolyl Oligopeptidase Induces In vitro Secretion of Proinflammatory Cytokines by Peritoneal Macrophages - Portugal_2017_Front.Microbiol_8_155 |
| Author(s) : Portugal B , Motta FN , Correa AF , Nolasco DO , De Almeida H , Magalhaes KG , Atta AL , Vieira FD , Bastos IM , Santana JM |
| Ref : Front Microbiol , 8 :155 , 2017 |
| Abstract : |
| PubMedSearch : Portugal_2017_Front.Microbiol_8_155 |
| PubMedID: 28223969 |
| Gene_locus related to this paper: myctu-RV0457C |
| Title : Transient up-regulation of a prolyl endopeptidase activity in the microsomal fraction of rat liver during postnatal development - Matsubara_1998_Eur.J.Biochem_252_178 |
| Author(s) : Matsubara Y , Ono T , Tsubuki S , Irie S , Kawashima S |
| Ref : European Journal of Biochemistry , 252 :178 , 1998 |
| Abstract : |
| PubMedSearch : Matsubara_1998_Eur.J.Biochem_252_178 |
| PubMedID: 9523728 |
| Title : Transient up-regulation of a prolyl endopeptidase activity in the microsomal fraction of rat liver during postnatal development - Matsubara_1998_Eur.J.Biochem_252_178 |
| Author(s) : Matsubara Y , Ono T , Tsubuki S , Irie S , Kawashima S |
| Ref : European Journal of Biochemistry , 252 :178 , 1998 |
| Abstract : |
| PubMedSearch : Matsubara_1998_Eur.J.Biochem_252_178 |
| PubMedID: 9523728 |
| Title : Transient up-regulation of a prolyl endopeptidase activity in the microsomal fraction of rat liver during postnatal development - Matsubara_1998_Eur.J.Biochem_252_178 |
| Author(s) : Matsubara Y , Ono T , Tsubuki S , Irie S , Kawashima S |
| Ref : European Journal of Biochemistry , 252 :178 , 1998 |
| Abstract : |
| PubMedSearch : Matsubara_1998_Eur.J.Biochem_252_178 |
| PubMedID: 9523728 |
| Title : Properties of Suc-GPLGP-MCAase and dipeptidyl-aminopeptidase in mouse calvaria-derived osteoblastic cells (MC3T3-E1) - Chikuma_1985_Calcif.Tissue.Int_37_183 |
| Author(s) : Chikuma T , Ishii Y , Kato T , Hiramatsu M , Kumegawa M |
| Ref : Calcif Tissue Int , 37 :183 , 1985 |
| Abstract : |
| PubMedSearch : Chikuma_1985_Calcif.Tissue.Int_37_183 |
| PubMedID: 2988719 |
| Title : Properties of Suc-GPLGP-MCAase and dipeptidyl-aminopeptidase in mouse calvaria-derived osteoblastic cells (MC3T3-E1) - Chikuma_1985_Calcif.Tissue.Int_37_183 |
| Author(s) : Chikuma T , Ishii Y , Kato T , Hiramatsu M , Kumegawa M |
| Ref : Calcif Tissue Int , 37 :183 , 1985 |
| Abstract : |
| PubMedSearch : Chikuma_1985_Calcif.Tissue.Int_37_183 |
| PubMedID: 2988719 |
| Title : Properties of Suc-GPLGP-MCAase and dipeptidyl-aminopeptidase in mouse calvaria-derived osteoblastic cells (MC3T3-E1) - Chikuma_1985_Calcif.Tissue.Int_37_183 |
| Author(s) : Chikuma T , Ishii Y , Kato T , Hiramatsu M , Kumegawa M |
| Ref : Calcif Tissue Int , 37 :183 , 1985 |
| Abstract : |
| PubMedSearch : Chikuma_1985_Calcif.Tissue.Int_37_183 |
| PubMedID: 2988719 |