TXH1033
Precursor of TXH9179, a FtsZ inhibitor of Staphylococcus aureus (MRSA) multidrug-resistant (MDR) bacterial pathogen. Hydrolysis of TXH1033 is inhibited by Neostigmine
General
Type : Piperidine, Pyridine, Pro-Drug, Carboxamide, Sulfur Compound, Thiazole
Chemical_Nomenclature : N-(3-((6-Ethynylthiazolo[5,4-b]pyridin-2yl)methoxy)-2,6-difluorobenzoyl)-1-methylpiperidine-4-carboxamide
Canonical SMILES : C1=NC2=C(C=C1C#C)N=C(S2)COC3=C(C(=C(C=C3)F)C(NC(=O)C4CCN(CC4)C)=O)F
InChI : InChI=1S\/C23H20F2N4O3S\/c1-3-13-10-16-23(26-11-13)33-18(27-16)12-32-17-5-4-15(24)19(20(17)25)22(31)28-21(30)14-6-8-29(2)9-7-14\/h1,4-5,10-11,14H,6-9,12H2,2H3,(H,28,30,31)
InChIKey : TYMQATVASFZHOA-UHFFFAOYSA-N
Other name(s) :
Target
Structures : No structure
Families : ACHE
References (3)
| Title : Structural and Antibacterial Characterization of a New Benzamide FtsZ Inhibitor with Superior Bactericidal Activity and In Vivo Efficacy Against Multidrug-Resistant Staphylococcus aureus - Bryan_2023_ACS.Chem.Biol__ |
| Author(s) : Bryan E , Ferrer-Gonzalez E , Sagong HY , Fujita J , Mark L , Kaul M , LaVoie EJ , Matsumura H , Pilch DS |
| Ref : ACS Chemical Biology , : , 2023 |
| Abstract : |
| PubMedSearch : Bryan_2023_ACS.Chem.Biol__ |
| PubMedID: 36854145 |
| Title : Structural and Antibacterial Characterization of a New Benzamide FtsZ Inhibitor with Superior Bactericidal Activity and In Vivo Efficacy Against Multidrug-Resistant Staphylococcus aureus - Bryan_2023_ACS.Chem.Biol__ |
| Author(s) : Bryan E , Ferrer-Gonzalez E , Sagong HY , Fujita J , Mark L , Kaul M , LaVoie EJ , Matsumura H , Pilch DS |
| Ref : ACS Chemical Biology , : , 2023 |
| Abstract : |
| PubMedSearch : Bryan_2023_ACS.Chem.Biol__ |
| PubMedID: 36854145 |
| Title : Structural and Antibacterial Characterization of a New Benzamide FtsZ Inhibitor with Superior Bactericidal Activity and In Vivo Efficacy Against Multidrug-Resistant Staphylococcus aureus - Bryan_2023_ACS.Chem.Biol__ |
| Author(s) : Bryan E , Ferrer-Gonzalez E , Sagong HY , Fujita J , Mark L , Kaul M , LaVoie EJ , Matsumura H , Pilch DS |
| Ref : ACS Chemical Biology , : , 2023 |
| Abstract : |
| PubMedSearch : Bryan_2023_ACS.Chem.Biol__ |
| PubMedID: 36854145 |